Objective To evaluate the clinical efficacy and safety of combined therapy of Chinese and West-ern medicine in the treatment of schizophrenia.Methods According to the digital table,130 patients with schizophre-nia were randomly divided into the observation group and control group,with 65 cases in each group.The control group was treated with perphenazine and other Western medicine treatment,the observation group was treated based on the control group with Jieyu Kaiqiao pill added,The clinical curative effect,PANSS score and adverse drug reaction of both groups were compared.Results In the observation group,the total effective rate was 96.92%,significantly high-er than that of the control group (72.31%);After treatment,PANSS score of observation group was (42.68 ±6.11), while it was (55.12 ±6.45)in control group.The PANSS scores of both groups were significantly lower than that before treatment,PANSS score of observation group was significantly lower than that of the control group,there was significant difference between groups(t=6.61,P<0.05);the incidence of adverse reaction of the observation group was 10.77%,significantly lower than the control group (58.46%);the difference was statistically significant (χ2 =32.66,P<0.05).Conclusion Jieyu Kaiqiao pill combined with Western medicine for the treatment of schizophre-nia can significantly improve the clinical efficacy,reduce the incidence of adverse drug reactions.

Objective : To investigate the effect of electroacupuncture (EA) treatment at pinch points (EX⁃B2) on motor function and Notch signaling pathway after spinal cord injury(SCI) . Methods : Seventy⁃two Sprague⁃Dawley (SD) male rats weighing (250 ± 20) g were randomly divided into sham operation group , SCI , electroacupuncture group (SCI + EA) and acupuncture group (SCI + AP) , with 18 rats in each group. A rat acute SCI model of T10 was established by the modified Allen ′s method. The SCI + EA and SCI + AP groups received 15 minutes of electro acupuncture or acupuncture treatment per day. The motor function of the hind limbs of rats was assessed by Basso , Beattie and Bresnahan ( BBB) scoring method , the pathological recovery changes of spinal cord tissues were observed by Hematoxylin⁃eosin (HE) staining , and the mRNA and protein expression levels of Hes 3 , Notch 3 and Notch 4 were detected by real⁃time quantitative PCR and estern blot method , respectively , after 3 , 7 and 14 days of intervention. The expression of glial fibrillary acidic protein (GFAP) was detected by immunohistochemistry after 14 days of intervention. Results : Compared with the sham group , the BBB scores were reduced in rats after SCI surgery and there was significant hemorrhage , structural destruction and degeneration of spinal cord tissue ( P < 0. 05) , while the SCI + EA and SCI + AP groups were milder than the SCI group (P < 0. 05) . The mRNA expression levels and protein expression levels of Hes 3 , Notch 3 and Notch 4 as well as the expression levels of GFAP appeared significantly higher in the SCI group compared with the sham group (P < 0. 05) , while the SCI + EA group appeared lower compared with the SCI group (P < 0. 05) . Conclusion EA of EX⁃B2 can improve the locomotor function of rats with SCI , which may be related to inhibiting the expression of GFAP and the activation of Notch signaling pathway.

Objective : To observe the effects of brain-computer interface-controlled pedal training system on bal- ance function and serum interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels in ischemic stroke pa- tients． Methods : Forty patients with ischemic stroke who were hospitalized from September 2022 to September 2023 were selected as observation subjects．The patients were equally divided into stroke control group and stroke experimental group according to the random number table method．At the same time，20 healthy subjects with similar gender and age were recruited as the healthy control group to collect relevant plantar pressure data．Patients in the stroke control group received conventional rehabilitation training including the upper and lower extremity active and passive motor training system，and the stroke experimental group replaced the upper and lower extremity active and passive motor training system in the stroke control group with the brain-computer interface-controlled pedal training system for rehabilitation treatment，and other things remained unchanged．Bilateral plantar pressure symmetry index (SI) and center of body pressure ( COP) swing area were collected from both groups of stroke patients with eyes open and closed using the plantar pressure assessment system before and after 4 weeks of treatment．Fugl-meyer low- er extremity motor function score (FMA-LE) and berg balance scale (BBS) were used to evaluate the two groups of stroke patients．Serum IL-6 and TNF-α levels were also compared between the two groups before and after treat- ment. Results : ① The SI value and COP swing area in the eyes open and closed state improved in both groups of stroke patients after treatment compared with that before admission，and the results of the stroke experimental group were better than those of the stroke control group (P ＜0. 05) ，but there was still a gap with the healthy control group (P＜0. 05) . ② The BBS and FMA-LE scores of stroke patients in both groups were higher after treatment than before treatment，and the scores of the stroke experimental group were greater than those of the stroke control group，with statistically significant differences (all P＜0. 05) . ③ Serum IL-6 and TNF-α levels decreased in both groups of stroke patients after treatment compared with before，and the degree of decrease in serum IL-6 and TNF-α levels in the stroke experimental group was greater than that in the stroke control group，and the difference was sta- tistically significant (P＜0. 001，P＜0. 05) ． Conclusion Brain-computer interface-controlled pedal training sys- tem has a facilitating effect on the recovery of balance function in hemiplegic patients with ischemic stroke，and its mechanism may be related to the reduction of serum IL-6 and TNF-α levels.

Objective: The gene engineering technique was used to express the P[6] genotype rotavirus (rotaviruses, RVs) GST-VP8^*-Z84 protein from pigs, and the binding characteristics of the protein to oligosaccharide and salivary receptor were studied. Methods: The GST-VP8^*-Z84 protein was purified by GST Escherichia coli expression system and affinity chromatography using porcine P[6]. Enzyme-linked immunosorbent assay (ELISA) saliva binding test and oligosaccharide binding test were used to analyze the binding characteristics of the genotype to receptors. Results: Porcine P[6] GST-VP8^*-Z84 protein bound well to mucin core 2. Conclusions The potential receptor of P[6] RV may be the core of mucin, which may provide the experimental basis and theoretical basis for the mechanism of rotavirus and receptor interaction and the development of RV vaccine and highly effective therapeutic drugs.