The polypeptides (PCF) were isolated from Chlamys farreri (Mr 800 -1000). The antioxidative mechanisms of PCF were studied in this paper. It has been shown that superoxide anion free radical and hydroxyl free radical were scavenged by PCF (3%, 15%). The oils and fats peroxide values (POV) and the contents of MDA were also determined. The results showed that the percentage scavenging superoxide anion free radical were 11- 7% and 41. 8% ,scavenging hydroxyl free radical were 8-6% and 38. 4% respectively. It could decrease the oils and fats POV and the contents of MDA in 5d and 10d(P

Objective To provide laboratory data of Chinese medicine peeling for clinical application.MethodsThe experimental durgsexposed at different times was investigated to observe cutaneous damage in guinea pigs. Results Three days after the application of the Chinese drugs, the extents of damage of the skin was as follows: 0.22?0.06 mm in depth(in malpighian and dermis papillary layer) in NeFuji group; 0.53?0.03mm(in dermis reticular layer)in Baker Gorden liquid gruop;0.10?0.02 mm(in superficial stratum corneum layer)in Jessner liquid group;0.12?0.03 mm(in stratum corneum layer)in group of lower concentration NeFuji. In groups of Chinese medicinal peeling and Baker Gorden liquid, solidification and necrosis of corneum protein were noted and rearrangement of collagenous fiber in upper middle layer of derma took place. The layer of dermis reticulum was infiltrated by neutrophilic granulocytes, lymphocytes and macrophages. No skin damage was found in control group. Conclusions The Chinese medicinal peeling is superior to chemical peeling in terms of controlling the depth and avoidance of scar formation, acceleraes the metabolism of dead and injured cells of epidermis with thickening of the dermis layer and disappearance of wrinkles, and reaches the goal of tender skin.