Utilizing the classical method——destruction test of thermostatic heat acceleration and using the residual content of total anthraquinone of Radix et Rhizoma Rhei as an index, the shelf life of Maren Soft Capsules was predicted as 2.13 years when the data were computed and dealt according to Arrhenius eguation

Objective To investigate the optimum techniques for processing Yuhuanlian with microwave. Methods Nine samples were obtained by orthogonal design. Thin-layer chromatography was used to determine berberine in Yuhuanglian. The content of berberine was taken as the index for the evaluation on the superiority of processing techniques. Results The optimal processing techniques for Yuhuanglian with microwave was suggested as follows:A2B2C3, moistened for 90 minutes, put 2 cm thick, with 80% of the microwave, heating 3 minutes. Conclusion The method is simple, easy to control, easy to use, easy to promote, and the quality of processed products is better.

Objective To discuss the best extracting technology of Evodia rutaecarpa juice——crude drug processing adjuvant of Yuhuanglian with water.Methods The content of 9 samples extracted according to orthogonal tests were mensurated by UV-spectrophotometry,and the extract methods were estimated with the content of total alkaloid in Evodia rutaecarpa as index.Results The technology of A3B2C1 that was marinated 60 minutes,added the water with 12,9.6 folds,extracted for 40 minutes,and extracted 2 times,which obtained the highest content of total alkaloid.Conclusion This test offered a pressing,feasible and best extracting technology of preparation of crude drug processing adjuvant of Yuhuanglian——Evodia rutaecarpa juice.

Objective To optimize the producing area and parts of Gardenia roots. Methods Oleanolic acid 3-acetate was hydrolysed into Oleanolic acid in Gardenia roots from 10 different origins, and root, stem, leaf of Gardenia from Liuyang Hunan, and the content was determined by HPLC. Results The content of oleanolic acid 3-acetate in Gardenia roots of different origins from high to low was:Shaodong, Liuyang of Hunan>Anji of Zhejiang, Guiyang of Hunan>Ningxiang, Anhua of Hunan, Zhangshu of Jiangxi>Liling, Pinjiang, Youxian of Hunan. The content in root was 2 times of that in stem and leaf. Conclusion Experimental data were provided for the optimization of producing area and part of Gardenia roots.

Objective: To establish a method for determining the content of dracorhodin as an indicator in the quality control with methodological studies to provide basis for the preparation process study of Qilisan gel. Methods: An HPLC method was used with a DiamonsilR C18 (250 mm ×4. 6 mm, 5 μm) column, the detection wavelength was set at 440 nm and the column temperature was 30 ℃. Acetonitrile-0. 05 mol·L-1 sodium dihydrogen phosphate solution (45 ∶ 55) was used as the mobile phase, and the flow rate was l. 0 ml·min-1 . Results: The content of dracorhodin was in a good linear relationship (r =0. 999 6) within the range of 1. 632-64. 250 μg·ml-1 , and the average recovery was 99. 02%(RSD =0. 77%, n =6). The number of theoretical plates was calculated as 7 100 according to the dracorhodin perchlorate peak without any interference from the negative sample. Conclusion: The method is objective, accurate and sensitive with high reliability, easy operation and fast process. The measurement results can be used as the quality control basis for the preparation process study of Qilisan gel.

OBJECTIVE:To prepare diclofenac sodium controlled release pellets and investigate the mechanism of re?lease.METHODS:Single-factor method was used to investigate the influence of the composition of solvent system in coating solution,the concentration of coating material,porogenic agent and plastifier on the release rate of drug.RESULTS:When the concentration of coating material and the proportion of water increased,the release rate of pellets was increased;the release rate was further increased with PVP K30 added.CONCLUSION:The pellets belongs to the matrix-coating pellets,and the release mechanism varies with the change of coating thickness.

OBJECTIVE:To probe into the rational drug use condition in Shenzhen area and to promote the rational drug use level. METHODS: A multi-center randomized parallel test was conducted in 6 different levels of hospitals in Shenzhen area. In which the prescriptions in two months and the outpatients visiting the hospitals on that day were surveyed on the spot in respect of the international rational drug use (RDU) indicators then the data were analyzed statistically. RESULTS: Prescription indicators were as follows: the average number of drugs was 2.44; the percentage of antibiotics prescribed was 43.7%and that for injection was 22.3%. Patient care indicators were as follows: the average consultation time was 6.97 minutes; average dispensing time was 16.77 seconds; percentage of drugs actually dispensed was 100%; percentage of drugs actually labeled was 100%; percentage of patients’ knowledge of correct use of drugs was 96.5%. CONCLUSIONS: The rational drug use level in Shenzhen area is still low and problematic and the care given by doctors and pharmacists to the patients is insufficient, which remain to be improved and tackled.

Objective: To study the effects of procession with wine on the blood-quickening and stasis-transforming actions of Radix Salviae Miltiorrhizae and Radix et Rhizoma Rhei. Methods: The blood stasis model of rat was established by Adr or cold. The effects of the processed products of Radix Salviae Miltiorrhizae and Radix et Rhizoma Rhei on thrombocyte adhesiveness and aggregaltion, prothrombin time (PT), thrombintime(TT), (PTT) were observed.Results: The raw and mix-fried Radix Salviae Miltiorrhizae with yellow wine and white liquor, the steamed Radix et Rhizoma Rhei with wine could obviously decrease thrombocyte adheziveness and aggregation, prolong PT, TT and PTT. The actions of the mix-fried Radix Salviae Miltiorrhizae with wine and the steamed Radix et Rhizoma Rhei with wine were stronger than that of their raw products (P

Objective:To establish a method for the determination of asperosaponinⅥin Dieda Cuyu tablets by HPLC. Methods:A Hypersil C18(250 mm ×4.6 mm,5 μm)column was used. The mobile phase was acetonitrile-water(30∶70) with a flow rate of 1.0 ml·min-1 . The detection wavelength was 212 nm, the column temperature was room temperature,and the injection volume was 10μl. Results:AsperosaponinⅥ showed a good linear relationship within the range of 0. 04-0. 32 μg(r=0. 999 6). The average recovery was 97. 84%(RSD=1. 70%, n=6). Conclusion:The method is simple,accurate and reproducible, which can be used in the deter-mination of asperosaponinⅥ in Dieda Cuyu tablets.