This paper presents a development model of resource information institute from organic integration the institute of information and library.The all data of resources-information institute come from and serve for theoretical research,clinical practice,and scientific research of TCM.Comparing with usual research institute and library,the resource information institute has five dominant positions,which are subjects,scientific researches,resource,professionals and services.

EML4-ALK fusion oncogene represents a new molecular target which appears mainly in lung adenocarcinoma.EML4-ALK is detected more frequently in young non-small-cell lung cancer patients who never or light smoke.ALK inhibitors(crizotinib)for the treatment of the EML4-ALK-positive non-small cell lung cancer has a high response rate.This finding can improve the individual treatment of non-small cell lung cancer.

Recent researches have shown that gut microbiota play an important role in pathogenesis of immune-related disorders.Type 1 diabetes mellitus,as an autoimmune disease,has received increasing attention,especially in terms of the relationship between the pathogenesis and intestinal microbiota.Change of gut microbiota is an important risk factor of the pathogenesis of type 1 diabetes mellitus which have been confirmed with the animal model studies.This article reviews the role of gut microbiota in the pathogenesis of type 1 diabetes mellitus,and the influence of gut microbiota on host immune response for possible prevention and treatment of type 1 diabetes mellitus in the future.

The donors' complete autonomy and voluntariness for donation is the core of ethical acceptability of living organ transplantation.Deep in the donors' heart,the awareness of self-respect and the altruism are two contradictory tendencies both in psychology and behavior.As the existence of the tension of self-respect awareness and altruism,it becomes particularly difficult and complex for the living organ donors to make autonomous decisions.This paper analyzed the tension of self-respect awareness and altruism,discussed the emotional and ethical contradictory,and proposed some suggestions based on this,hoping to provide a good internal environment and external support for the potential donors to make reasonable free decisions and guarantee the ethics of living organ transplantation.

The application of transesophageal echocardiography (TEE) in perioperative monitoring was introduced,and its involvement in non-cardiac surgery was described.The advantages and disadvantages of TEE were analyzed when applied to cardiac and non-cardiac operations for congenital heart disease,coronary disease,vascular heart disease,aorta disease and etc.The abuse of vasoactive drug or fluid is avoided due to subjective evaluation on cardiac function and volume load.TEE facilitates the anesthetist in diagnosis and evaluation of the patient with heart diseases,and the surgeon in immediate assessment of the operation,which can be used for real-time monitoring of cardiac function and hemodynamics.

The standard of traditional Chinese medicine (TCM) literature metadata is the technological basis and premise of the TCM resource administration and sharing. This paper studied the TCM literature metadata design condition by defining the object of description and discussing the necessity of TCM literature metadata preliminary. It put forward metadata framework structure and element extension principles so as to carry out the specific design work. In order to enhance the practicability of metadata, two means of expression including system table and metadata dictionary were designed with special provisions on description detail rules of metadata dictionary. The design principle of TCM literature metadata was summarized. The issue of balance between accuracy and entirety was considered in the metadata designing.

As a new type of treatment for ovarian cancer,the fertility sparing surgery is put forward for patients who has fertility requirements and the surgical indication.But the indications and safety are still controversial at present on the international.The operation is based on the traditional surgery way,the retention of the uterus and at least one side of the ovary,and then the corresponding adjuvant chemotherapy and ovarian protection,and choosing the right pregnancy timing based on individual difference,to the excellent oncologic outcomes and the favorable reproductive outcomes.

Taking eugenics,family planning and reproductive human-assisted projects for instance,the article discusses the conflicts between modern biotechnology and the contemporary ethics.It distinguishes the concepts of life quality and that of health,and advocates that the modern medicine should conduct to be in pursuit of the high quality of life.Finally,it puts forward that we should upgrade the quality of individual's life in the circumstance of a stable and integrated communal ethics.Biotechnology may be developed immeasurably,but should be used restricted and morally.

AIM: To explore the relationship of the decrease of the catharticizing action and the conjugated anthraquinone after Radix et Rhizoma Rhei was in the process of stirred-fry-with wine by comparing the content of conjugated anthraquinone among different processing Radix et Rhizoma Rhei in the solution decocted by water and extrected by methanol. METHODS: The spectrophotometer was used to assay the content of free anthraquinone and conjugated anthraquinone of different proccssing Rudix et Rhizoma Rhei in the solution decocted by water and extracted by methanol. RESULTS: In the solution decocted by water there was little difference in free anthraquinone between the raw and the processing products, however, the conjugated anthraquinone of the precessing product was much higher than the raw. CONCLUSION: The decrease of the conjugated anthraquinone can’t fully account for the reduction of the catharticizing action of Radix et Rhizoma Rhei in the process of stirred-fry with wine. The real cause needs to be explored in many aspects.