2.Related risk factors of vascular dementia in stroke patients
Clinical Medicine of China 2008;24(z1):4-5
Objective To explore the risk factors of vascular dementia (VD) in stroke patients, expecial-ly, the relationship between VD and carotid artery atherosclerosis. Methods 64 patients with cerebrovascular dis-ease , who had a history of stroke , were divided into VD groups (n = 64) and control group (n = 60). The age, disease course, education and blood lipid and carotid artery stenosis were compared. Results The age of patients , course of disease ,educational levels, the serum levels of TC ,TG, LDL and internal diameter of carotid artery were different between the two groups (P < 0.05 ). Conclusion The age of patients , course of disease , education, the serum levels of TC ,TG ,LDL and carotid artery atherosclerosis are related to vascular dementia in stroke patients.
3.Application of the 18F-FDG SPECT-CT combined with the images of CT in the diagnosis of lung cancer
Chinese Journal of Primary Medicine and Pharmacy 2015;22(3):385-387
Objective To investigate the clinical value of the 18F-FDG SPECT-CT combined with the image of CT in the diagnosis of lung cancer.Methods Retrospectively analysis images of 18F-FDG SPECT-CT and CT of 162 patients pulmonary tumor-like lesions from January 2013 to October 2013 were conducted.All the patients have been confirmed by the pathological mechanism or cytologic examination.Each patient has been firstly diagnosed by the 18F-FDG SPECT-CT along and then combined with the images of CT.The sensitive rate and the accurate rate of two methods were compared by x2 test.Results There were 40 benign lesions and 114 malignant ones in 162 patients.The sensitive rates of the two methods were 86.0% and 96.5% (x2 =6.63,P < 0.05).The accurate rates of the two ways were 79% and 96.3% (x2 =7.76,P < 0.05).The differences were statistically significant.Conclusion 18F-FDG SPECT-CT combined with the images of CT can increase the diagnostic sensitivity and accuracy.It has important clinical value.
4.Alteration of erythrocyte immune function in patients with chronic gastritis
International Journal of Laboratory Medicine 2009;30(7):649-650
Objective To investigate the change of immunologic function of red blood cell (RBC) in patients with chronic gastritis. Methods The immunologic function of RBC in 88 cases of chronic gastritis was dynamically detected with yeast rosette method. Results The results showed that RBC-C3b receptor rosette (RBC-C3b-RR) rate and RBC immune adherence enhance factor (RFER) rate were significantly lower (P<0.05) and RBC immune complex rosette (RBC-ICR) rate and RBC immune adherence inhibitor factor (RFIR) were significantly higher (P<0.05) in the patients with atrophic gastritis than those in control group. In the patients with superficial gastritis, the difference had no distinct significance (P>0.05). Conclusion The immunologic function of red blood cell (RBC)measurement plays an important role in differential diagnosis and prognosis evaluation of chronic gastritis.
5.mRNA Expression of c-myc Gene in the Hyperacute Rejection of Xe notransplantation
Chinese Circulation Journal 2001;16(1):67-69
Objective:To research expression and function of c-myc gene in hyperacute r ejection of xenotransplantation. Method:Through the model of hyperacute rejection of xenotransplantation wit h isolated rat heart perfused with human plasma,we detected c-myc mRNA expressi on and cell localization with in situ hybridization in hyperacute rejection. Result:c-myc mRNA increased expression in the endothelium cell of heart.Th e value of signal is 450.09±409.99.The value of signal of group of control is 1 74.40±51.50(p<0.05)。 Conclusion:From these study findings,it would appear that hyperacute rejecti on is associated with the elevation of c-myc mRNA expression.
6.Determination of Serum Concentration of Ganciclovir in Dogs and Study on Relative Bioavailability of Ganciclovir Dispersible Tablets
China Pharmacy 1991;0(05):-
OBJECTIVE:To establish an HPLC method for determination of ganciclovir in serum of dogs and to study pharmacokinetics and relative bioavailability of Ganciclovir dispersible tablets.METHODS:The determination was performed on Dikma DiamonsilTM C18 column.The mobile phase consisted of 0.015 mol?mL-1 monobasic potassium phosphate buffer solution (pH 2.50,containing 0.25% acetonitrile) with flow rate of 1.75 mL?min-1 at detection wavelength of 254 nm.The column temperature was set at 40 ℃.In a randomized cross-over study,a single dose of dispersible tablets and the capsule were given to 6 dogs.An HPLC method was used to determine plasma concentration of ganciclovir in dogs and the pharmacokinetic data were treated by DASver1.0 software.RESULTS:The linear range of ganciclovir were 0.050 25~100.5 ?g?mL-1;the methodological recovery was larger than 90% (RSD
7.Medial Collateral Ligament Reconstruction with Semitendinosus Autograft for Medial Instability of the Knee:Report of 12 Cases
Chinese Journal of Minimally Invasive Surgery 2005;0(11):-
Objective To investigate the effect of medial collateral ligament reconstruction using semitendinosus autograft.Methods A total of 12 patients with medial collateral ligament injury received knee examinations.Among them,2 had lateral meniscus injury,and received partial resection of the lateral meniscus;2 had cruciate ligament(CL) injury(anterior CL in one and posterior CL in the other),and underwent bone-ligament-bone reconstruction.Medial collateral ligament reconstruction was performed using the semitendinosus tendon autograft ingrowth in the tibial tunnel.Results Primary healing was achieved in all the cases.In 10 of them,the stability of the knee was regained in 6-month follow-up;stress X-ray examination showed that the medial joint space was smaller than the contralateral one by less than 5 mm,and the position of the interference screw was optimal.Of the 12 patients,11 achieved an active knee flexion between 0? and 120?,the other,who had fracture of the lateral condyle of the femur,had a flexion of 90?.Conclusions Semitendinosus autograft provides sufficient tension for medial collateral ligament reconstruction.The fixation of the knee and the closure of the joint capsule can be achieved by using the method.
8.Application of computer technology to developing physical therapy instrument for bone injury
Chinese Medical Equipment Journal 1993;0(06):-
According to the principle of physical therapy, this paper discusses the feasibility to apply electromagnetic physiotherapy technology and IF modulation current technology to developing the computerized physical therapy instrument for bone injury. Such information of the instrument is introduced as its function, design principle, hardware structure and program composition.
9.Expression of hemeoxygenase-1 and change of superoxide dismutase activity in perihematoma after intracerebral hemorrhage in rats
Journal of Clinical Neurology 1988;0(02):-
Objective To study the expression of hemeoxygenase-1 (HO-1) and change of superoxide dismutase (SOD) activity in perihematoma after intracerebral hemorrhage (ICH). Methods The rats were randomly divided into sham operating group and intracerebral hemorrhage group.Rat ICH models were induced using stereotactic infusion autologous blood 50 ?l into the caudate nucleus. At the due time, the rats were killed and brain tissues were removed for detection of HO-1 and measurement of SOD by immunohistochemical and xanthine hydrocarbonylation methods. Results Following ICH, few HO-1 positive cells were observed in brain tissue perihemota at 6 h, peaked at 48 h ( P0.05), then decreased gradually and reached the minimum at 72 h ( P0.05). The change of SOD in brain tissue perihematoma was negatively correlated with the expression of HO-1 (r=-0.878, P
10.Novel therapy for Hodgkin lymphoma: reports in the 55th ASH annual meeting
Journal of Leukemia & Lymphoma 2014;23(1):5-6,8
The 55th ASH annual meeting published a special report about Hodgkin lymphoma,which mainly contains management of early-stage Hodgkin lymphoma,novel targeted therapy and the optimal treatment of lymphocyte-predominant Hodgkin lymphoma.The therapy of Hodgkin lymphoma should be individualized,in order to improve both PFS and OS.More clinical trials should be designed on the target therapy and the treatment strategy of nodular lymphocyte-predominant Hodgkin lymphoma.