Daurian Thermopsis (Thermopsis daurica Czefr.),Gobian Thyme(Thymus gobicusTschern.) and Mogilev Mallow (Malva mohileviensis Downer) are separately used as mucolytic and anti- inflammatory treatment in non-conventional medicine. Therefore, we prepared infusion of these herbals compound called as a Tetima. It is important to produce new pharmaceutical preparation that mucolytic effective for upper and lower respiratory tract inflammatory disease. Despite the wide use of this plants as herbal medicine in the treatment of respiratory tract diseases, their toxicity is still unknown. Therefore, we evaluated the possiblesubchronic toxic effects of Tetima herbal compound inrats. Tetima herbal compound infusion was prepared in distilled water (1:10). We used 15 Wistar breed rats (230-370 gr) in this study. Subchronic toxicity study for 28 days was done by oral administration at doses of 0.5ml normal saline (control) and 200 mg/kg, 400 mg/kg of infusion in Wistar ratsThe obtained data revealed that oral administration of Tetima in rats for 28 successive days had no significant changes the hematological parameters in rats all over the period of the experiment, and there are no significant increases in the activity of aspartate aminotransferase, alanine aminotransferase, creatinine and urea, between control and treated groups (p>0.05). The histopathological studies of the major vital organs like liver, kidney and heart recovered from the control and treated groups showed normal architecture suggesting no detrimental changes and morphological disturbances. These results show that the Tetima herbal compound is low toxic in subchronic toxicity study.

BACKGROUND. Previous retrospective study from our team showed that RDW significantly increased in chronic heart failure (CHF). OBJECTIVE. The aim of the study was to compare the value of RDW-CV with NT-pro BNP and evaluate sensitivity and specificity of RDW for diagnose of heart failure. MATEREALS AND METHOD. Here, we analyzed 20 patients who were suffering from heart failure and were treated in the department of Cardiology, First Clinical Hospital between in June 2017. All patients in the study group were underwent a complete blood count, immunoassay for NT-proBNP. The ejection fraction was analyzed by ECHO cardiograpy. RESULTS. 85.0% of patients were male and remained was female. RBC and RDW was significantly differentially measured in between CHF groups (р= 0.028 p=0.0001). In control groups without heart failure NT-proBNP was estimated up to 100 pg/ml, whereas it was definitelly increased in patient with CHF (р=0.0001). There was strong correlation between RDW and NT-proBNP (r =0.846, p=0.0001). sensitivity and specificity of RDW was 89%, and 74.3 % respectively in CHF. CONCLUSION. According to the our results there was direct correlation between RDW-CV and heart failure (p=0.035). RDW-CV migh be cost effective and routine laboratoty marker to evaulate CHF.