No abstract available.
Melanosis*

No abstract available.
Melanoma* ; Melanosis*

Background: Melasma is an acquired hyperpigmentary disorder occurring on sun-exposed areas of the face and neck. There is little information on its prevalence, epidemiology and clinical characteristics in the Philippines. Objective: To determine the prevalence, epidemiology and clinical characteristics of melasma in Philippine dermatology patients. Methods: This was a multicenter, cross-sectional study conducted from July to December 2013. The investigators determined the prevalence of melasma in 12,068 dermatology patients from six government hospitals and private clinics in Metro Manila, Philippines. The melasma patients, aged 18 years and above, were given self-administered questionnaires with topics related to demographic information and medical history. They were also examined by the investigators (dermatologists) to determine the clinical profile of their melasma. Results: Of the 12,068 dermatology patients who were seen at the selected hospitals and private clinics, 153 (1.26%) were clinically diagnosed with melasma. A majority of the melasma patients were Filipinos (73.20%), aged 41-50 years old (37.91%), with an average age of 42.40 + 9.68 years, and Fitzpatrick skin types III and IV (29.41% and 57.52%, respectively). Melasma was more prevalent in females (81.70%), most of whom had prior history of pregnancy (76.8%). Oral contraceptive use was also reported in 37.6% of the female patients from which 63.83% have used it for only 1 year or less. A majority had no coexisting thyroid disease (75.16%) and daily sun exposure was limited to 1 hour or less for most patients (43.14%). Their melasma was mostly malar in distribution (60.13%), epidermal (61.44%), and mild (51.63%) to moderate (27.45%) in severity. The average mMASI score was 4.63 + 3.32. Conclusion The prevalence of melasma was low among Philippine dermatology patients sampled. A majority of the melasma patients were Filipinos, aged 41-50 years old, with Fitzpatrick skin type IV, limited sun exposure, and no coexisting thyroid disease. They were mostly females with a prior history of pregnancy. Their melasma was mostly malar in location, epiderma type, and mild in severity. These descriptive data can serve as baseline information for further studies on melasma in the Philippines.
Melanosis ; Philippines

No abstract available.
Lasers, Dye* ; Melanosis*

No abstract available.
Melanosis* ; Tranexamic Acid*

Clinical guidelines suggest that suspicious pigmented lesions of the plantar or palmar area require biopsy for early detection of acral melanoma. We present here a case of acral lentiginous melanoma in which various melanocytic atypia was observed at each biopsy site, including focal melanocytic proliferation. We suggest that this atypical melanosis is part of a contiguous phase of invasive tumor growth, which is known as the very early stage of melanoma in situ. In addition, noninvasive dermoscopy has been effective for the early discovery of hidden lesions of acral melanoma.
Biopsy ; Dermoscopy ; Melanoma ; Melanosis

No abstract available.
Melanosis* ; Platelet-Rich Plasma*

BACKGROUND: Melasma, a common chronic pigmentary disorder, is resistant to various treatments. Recently, pulse-in-pulse type of intense pulsed light (PIP IPL) has been introduced as a treatment for melasma. It can emit multiple peaks during one pulse wave to deliver photothermal energy more effectively with gentle and even low energy so that complications are minimal. OBJECTIVE: The purpose of this study was to compare the efficacy and safety of PIP IPL to low-fluence, multi-pass, Q-switched Nd:YAG laser in the treatment of facial melasma. METHODS: Fifteen female patients with melasma who had Fitzpatrick skin type III or IV were enrolled in this study between November 2014 and April 2015. Patients underwent 6 sessions of treatment at an interval of 1 week. One half of each patient's face was treated with 2 passes of PIP IPL with a fluence of 13~15 J/cm₂. The other half of the face was treated with 4 passes of Q-Switched Nd:YAG laser with a fluence of 1.6~1.8 J/cm₂. Results were evaluated at every visit, including modified Melasma Area and Severity Index (MASI) score, subject's global assessment, and investigator's global assessment. RESULTS: Modified MASI scores were significantly (p<0.05) reduced in both groups after 6 treatment sessions. Q-Switched Nd:YAG laser treatment was more effective than PIP IPL for the treatment of melasma, although the two treatments did not significantly (p=0.44) differ in effectiveness. However, the discomfort levels of patients in the PIP IPL group following procedures were significantly lower compared to those in the Q-Switched Nd:YAG group. CONCLUSION: The current investigation demonstrated that PIP IPL treatment for melasma in Korean women was not inferior to collimated low fluence Q-switched Nd:YAG laser treatment.
Female ; Humans ; Melanosis* ; Skin

30 patients with melasma (diagnosed according to Zaumseil, Klaus-Graupe) was treated by applying 2% hydroquinone in combing with 0.05% retinoic. After 6 month treatment, the disease recessed well and very well in 65.6%, the size of pigmented area reduced 87% in average, 15.6% of patients has reduced in 90-100% of size and 65.7% of 70-89%.
Melanosis ; Therapeutics ; Hydroquinones ; Tretinoin

30 patients aged 18-60 years old with melasma localized at the epiderm and epiderm plus mesoderm layer topically treated by 2% hydroquinone preparation within 6 months at the Venero-dermatol Institute were evaluated. Good and very good results reached in 42.5%. The size of lesion minimized by > 10% each months, especially 21% in the 2nd month. Mean size of lesion minimized by 75%. In 11.2% of patients, the size of lesion minimized by 90-100% and 56.3% of patients had got the lesion of 70-89% minimized size.
Therapeutics ; Melanosis ; Hydroquinones