Objective:To analyze 916 cases of endoscopically diagnozed reflux esophagitis(RE) and to explore the endoscopic and clinicopathologic characteristics of RE.Methods:Totally 916 RE patients from Lixiahe district in Jiangsu province(1997 2002) were graded with criterion made in Chinese Yantai in 1999.Some cases were subjected to pathology,age,sex,symptoms,endoscopic manifestations and pathology variety examination.Results:The incidence of RE was for 7.4% in endoscopic checked patients(916/12 376).The male to female ratio was 2.2∶1,mean age was (54.42?15.05),patients above 60 years old accounted for 46.5%.Only 32.6% of RE patients had typical reflux symptoms(426/916,299/916).Endoscopic diagnosis focused on Chinese Yantai standardⅠ Ⅱ (85.3%,781/916),pathology diagnosis focused on light to moderate degree,secondary RE was common in severe degree.Some patients were accompanied by bile reflux,esophagus gap hernia and peptic ulcer.Conclusion:The incidence of RE in Lixiahe district in Jiangsu province is rather high,it is common in middle aged and senior male patients(Ⅰ Ⅱ).Pathology variety is chiefly scalelike epithelial proliferation filled with chronic inflammatory cells.It was partly accompanied by atypical proliferation,erosion and ulcer,appearance of early cancer was occasionally found.The sensitivity of clinic symptoms diagnosis is lower than endoscopic diagnosis which is simple and of great value.