The purpose is to discuss the pattern of teaching,further strengthen the teaching innovation and improve the teaching quality,on the aspects of teaching contents,preparation of multimedia courseware,variety of teaching methods and establishment of teaching feedback system.

Objective To evaluate hepatitis B virus large surfsce protein(LHBs) in monitoring of antiviral treatment.Methods LHBs.HBV serum markers and HBV DNA loads in 46 patients with adefovir dipivoxil(ADV) therapy were monitored for the whole course(60 weeks).Enzyme linked immunosorbent assay(ELISA),time differentiate immunofluoresence assay and real.time polymerase chain reaction(RT-PCR)were performed to detect LHBs,HBV serum markers and HBV DNA loads,respectively.And correlation analysis was also performed.Results Both LHBs and HBV DNA declined during the ADV treatment.and the correlation coefficient was 0.97.but LHBs declined after HBV DNA.There were 20 patients with HBV DNA<5×102/mL at 60th week.in which 8 were LHBs negative;in 14 recurrent patients,the HBV DNA turned to negative and became positive again,3 with negative LHBs;while in 12 patients resistant to the ADV therapy.2 were LHBs negative.Conclusion Dynamic monitoring of LHBs is useful in the evaluation of antiviral treatment.

To explore the potential mechanism of Qinfei Dayuan Granules for the treatment of pneumonia by the network pharmacology, the potential active ingredients and drug targets of Qinfei Dayuan Granules were obtained through the Integrative Pharmacology-based Research Platform of Traditional Chinese Medicine (TCMIP). The "component-target-disease" network and PPI network were constructed by Cytoscape 3.7.2 software, and GO functional enrichment analysis and KEGG pathway enrichment analysis were performed on the TCMIP platform to obtain a multi-dimensional network analysis of the "Chinese medicinal materials-chemical components-key targets-action pathways" and to explore the mechanism of its multi-component multi-target multi-action pathways of Qinfei Dayuan Granules for the treatment of pneumonia. A total of 474 active ingredients and 865 drug targets were identified from Qinfei Dayuan Granules; the key core targets of drugs include NF-κB, TNF-α, MAPK3, IL-1β, PTGS and CASP3, etc.. The results of GO functional enrichment analysis showed that drugs may interfere with inflammation through biological pathways such as immune regulation and apoptosis. KEGG signal pathway enrichment analysis showed that it was mainly related to the diabetic complications AGE-RAGE signaling pathway, IL-17 signaling pathway, T cell receptor signaling pathway and tumor necrosis factor signaling pathway, etc.. Qinfei Dayuan Granules can exert its effect on the treatment of pneumonia through inflammatory response and immune system with multi-ingredient, multi-target and multi-pathway pharmacological characteristics.