AIM: To observe the effect of compound clindamycin liniment on acne vulgaris. 　METHODS: A multi-centre, open-label trial of compound clindamycin liniment in treating acne vulgaris. One hundred and fifty-three patients used compound clindamycin liniment on face three times per day for 4 wk.　RESULTS: The total excellent response rate was 83.0%. The total effect rate on pustule and papule was 96.1% and 80.7% respectively. The adverse reaction rate was 1.9%.　CONCLUSION: Compound clindamycin liniment is an effective and safe drug in the treatment of acne vulgaris.

Objective To evaluate the effect of schistosomiasis control in Yizhou City,Guangxi Zhuang Autonomous Re?gion,from 2011 to 2014,so as to provide the evidence for formulating the further prevention and control strategy. Methods The schistosomiasis surveillance data were collected and analyzed in Yizhou City from 2011 to 2014. Results From 2011 to 2014,770.38 hm2 was surveyed for the Oncomelania hupensis snails,and two snail infested sites were found,while no infected snails were found. Totally 3 524 residents were tested by ELISA for Schistosoma japonicum infection,and 38 cases were posi?tive. The positive rate of 2013 was significantly higher than those of other three years( χ2 = 15.08,P < 0.05). Totally 432 rats and 28 dogs were dissected and 1 697 cattle were examined by the stool test,but no positive cases were found. Conclusions The indicators of schistosomiasis surveillance are basically stable in Yizhou City.

Objective To investigate the protective effect of Xinan granule on viral myocarditis in mice. Methods Viral myocarditis model was made by intraperitoneal inoculation with Coxsackie virus B3 in BALB/C mice. Mice were randomly devided into six groups:the normal control group, the model control group, the Xinan granule10、20、40 g/(kg?d) groups and the Binduzuo 0.1 g/(kg?d) group.After CVB3 infection 2 h, one set of mice were given drugs for 7 d.Blood and heart samples were obtained on the 8th day after CVB3 infection.The myocardial histopathologic changes were observed. The serum cardiac enzyme (LDH) were measured.The others were given drugs for 2 d before CVB3 infection, and for 7ds after CVB3 infection. The survival time were recorded for 20 ds. Results The myocardial histopathologic damage, LDH, cardiac index, punctate hemorrhage on heart surface in Xinan group reduced more significantly than that of the model control group. The survival time in Xinan group were longer than that of the model control group. Conclusion Xinan granule may have the preventional and therapeutic effect on viral myocarditis in mice.

AIM:To make a evaluation of high-dose Senmai(Radix Ginseng Rubra, Radix Ophiopogonis, Fructus schisandrae.)(HD-SM)in treating patients with advanced cancer.METHODS:32 patients with advanced cancer were assigned to treatment group. And 28 cases were assigned to the control group. The treatment group received chemotherapy and HD-SM, the control group received chemotherapy and the routine supporting treatment (except HD-SM). The toxicity and effect of all patients were observed, and the value of HD-SM was assessed.RESULTS:All cases in treatment group received 4 chemotherapy courses according to plan. The toxicities were tolerable, and the effect was satisfactory. All cases in the control group were only performed 1 course of treatmeur.CONCLUSION:HD-SM can decrease the effect of chemotherapy and reduce chemotherapeutic toxicities, and it is a very effective supporting treatment in chemotherapy.

Objective To discuss the application effect of task-driven basic nursing probation based on the action research. Methods Using the frame of Lewin's action research, with random sampling, we selected a class for the study, for the first time in the traditional training model, and the second time in the task-driven model based on the action research. and information was collected according to the interviews and diary records, narrative description was used for records of the results. Results Action research promoted changes in basic nursing probation model, constructed knowledge, ability and improved various kinds of ability of nursing students. Conclusions The task-driven probation model improved the quality of clinic practice, which proved to be effective.

Objective To understand the levels of plasma endothelin (ET) and calcitonin gene-related peptide (CGRP) in cough variant asthma(CVA) patients, and to investigate their correlation and clinical implications. Methods Thirty CVA patients,30 typical bronchial asthma patients and 25 healthy controls were recruited. Three milliliter limosis venous blood were drawn from each patient to measure the levels of plasma ET and CGRP by radioimmanity. Results ①The levels of ET in the CVA group and typical bronchial asthma group were higher than that in healthy controls (P < 0.01). Their values were (103.58±28.66) ng/L, (129.37±27.28) ng/L and (72.63±21.52)ng/L, respectively. The levels of CGRP in the CVA group and typical bronchial asthma group were (7.62±2.56) ng/L and(6.63±2.09)ng/L The level of CGRP in the healthy controls group was (21.60±3.29) ng/L. The first two groups were lower than the latter(P < 0.01). However, there was no significant difference between the CVA group and typical bronchial asthma group(P >0.05). ②ET and CGRP were negatively correlated in both CVA group(r= -0.819,P<0.05) and typical bronchial asthma group(r= -0.738,P<0.05). Conclusions ET and CGRP were negatively correlated in both CVA group and typical bronchial asthma group, which means that ET and CGRP were a couple of antagonistic factors participated in the regulation of CVA, and may play an important role in the process of CVA.

Objective To compare the changes in blood coagulation, fibrinolysis and endothelial damage in patients undergoing laparoscopic cholecystectomy with different durations of carbon dioxide pneumoperitoneum. Methods Sixty-four ASA Ⅰ orⅡpatients, aged 23-60 yr, weighing 45-82 kg, scheduled for elective laparoscopic cholecystectomy, were randomly divided into 3 groups according to the duration of pneumoperitoneum: duration of pneumoperitoneum ≤30 min group (group Ⅰ, n=21), 30 min ＜ duration of pneumoperitoneum ＜ 60 min (group Ⅱ, n=23) and duration of pneumoperitoneum≥ 60 min (group Ⅲ , n=20).The intra-abdominal pressure was maintained at 12-14 mm Hg. Venous blood samples were taken before surgery (baseline, T0 ),at the end of surgery(T1), and at 1, 2 and 3 d after surgery (T2-4) for determination of prothrombin time, activated partial thromboplastin time, concentrations of prothrombin fragment 1+2(F1+2), fibrinogen (Fib), tissue plasminogen activator and plasminogen activator inhibitor type-1 (PAI-1), and activities of antithrombin Ⅲ(AT-Ⅲ)and von Willebrand factor(vWF).Results Compared with groupⅠ , the vWF activity and PAI-1 concentration at T2 , concentrations of Fib, F1+2, PAI-1 and activity of vWF at T3 and concentrations of Fib and F1+2 at T4 were significantly increased, while the AT-IE activity at T3 was significantly decreased in group Ⅲ(P＜0.05) .Conclusion When the duration of pneumoperitoneum is short, no obvious changes in the blood coagulation, fibrinolysis and endothelial damage are observed postoperatively in patients undergoing laparoscopic cholecystectomy, and along with the prolongation of the duration of pneumoperitoneum, increased blood coagulation, reduced fibrinolysisand aggravated endothelial damage are observed postoperatively.

1.The sagittal and transverse diameters of 1,456 transverse foramina in 728cervical vertebrae were measured.The data are as follows:transverse diameter(mm) sagittal diameter (mm)Left Right Left RightMale(702 cases) 6.0?1.0 5.9?1.1 5.4?1.2 5.3?1.1Female(754 cases) 5.9?1.0 5.8?1.1 5.3?1.1 5.1?1.12.Among the 710 transverse foramina of 357 cervical vertebrae observed,mostof them are of the elliptical type.3.19.3% of double transverse foramen were found in 710 transverse foraminawhich were mostly encountered at the 6 th cervical vertebra.4.The mean value of the external diameter of the cervical part of the vertebralartery is 4?0.7mm.in 40 sides of specimens.5.63.1% of the vertebral artery in the 710 transverse foramina were foundmedial to its accompanying vein.6.According to the relationship between the sagittal(X_1)and transversediameter(X_2)of the transverse foramen and the diameter(Y)of the vertebralartery,a formula,(?)=1.859+0.172 X_1+0.24 X_2,of multiple regression was formulatedThus,the estimated diameter of the vertebral artery from the sagittal diameter X_1and transverse diameter X_2 of the transverse foramen could be obtained and it maybe helpful for clinical practice.7.In case of arthrosis,the vertebral artery could be compressed by the unco-vertebral joint which are found mostly at the level of the 4～5th cervicalvertebrae.

ObjectiveTo observe the effect of application of health education model on patients un-dergoing extracorpereal shock wave lithotripsy of urinary calculi. MethodsWe randomly divided 278 patients undergoing extracorporeal shock wave lithotripsy of urinary calculi into the experimental group(136 cases) and the control group(142 cases).The experimental group received health education according to the model of health education, while the control group adopted routine health education. The treatment effect of lithotripsy after 1 week,2 weeks and 1 month was evaluated. ResultsAfter health education,the cure rate at I week after lithotripsy was 50.7%, which was higher than that of the control group,28.2%, the cure rates at 2 weeks and 1 month were 58.2% and 86.0%, which were better than those of the control group, 49.0% and 70.4%. ConclusionsApplication of health education model can improve the treatment effect of extracorporeal shock wave lithotripsy of urinary calculi and alleviate pain of patients as soon as possible.

Objective To investigate the expression and correlation of cell cycle protein-D1 and Ki-67 in laryngeal cancer tis-sues.Methods Immunohistochemical streptavidin-perosidase ( SP) staining method was used to detect the expression of Cyclin D 1 and Ki-67 proteins in laryngeal squamous cell carcinoma tissues and their correlation between Cyclin D 1 and Ki-67 was analyzed .Re-sults Among 56 cases of Cyclin D1 positive over-expressed laryngeal squamous cell carcinoma tissues , 41 cases of Ki-67 had positive over-expression.Among 51 cases of Ki-67 low-expressed tissues, 35 cases of Cyclin D1 had low-expression.Spearman rank correlation test showed that expressions of Cyclin D 1 and Ki-67 in laryngeal squamous cell carcinoma tissues had a significant positive correlation ( rs =0.620, P <0.01).Conclusions Cyclin D1 and Ki-67 expressions in laryngeal squamous cell carcinoma have a significantly positive correlation .