Objective To explore the quality of life and its related factors among left‐behind children in Shandong and Si‐chuan provinces .Methods The cluster sampling method was used to select the study participants and thus each 3 rural primary schools were randomly chosen as the study sites in Shandong and Sichuan provinces .t‐test ,χ2 test and rank sum test were employed to perform univariate analysis ,and multivariate analysis was conducted using multiple linear regression .Results In this study ,there were totally 1804 participants with 778 left‐behind ones .There was statistical difference between left‐behind children and average children in each aspects of quality of life and the total score(P<0 .05) .Multiple linear regression analysis showed that the multiple influencing factors of the quality of life among left‐behind children in Shandong and Sichuan provinces were age ,the guardian、left‐behind time、parents′care and study result .Conclusion The quality of life among left‐behind children in Shandong and Sichuan provinces was not high and was affected by many factors .In order to improve the quality of life of left‐behind children ,the guardians should pay more attention to care and communicate with their children in the future education and management of left‐behind chil‐dren ,especially the elder ,long time left behind or poor grades ones .