China ; Humans ; Occupational Exposure ; Occupational Health ; Private Sector

Objective: To study the effects of propofol of clinical concentration on isolated heart function and metabolism of oxygen free radicals in rats with obstructive jaundice. Methods: Thirty-six rats were randomly divided into 2 groups (n = 18): sham operated group (SO) and bile duct ligation group (BDL). The isolated working hearts were perfused for 30 min and 6 hearts were randomly selected from each group to measure the contents of basic MDA and SOD activity in the heart tissue. The rest animals of each group were randomly separated into 2 subgroups (n = 6): K-H solution perfusion group and propofol perfusion group. The isolated working hearts in K-H solution perfusion group were perfused with K-H solution for 40 min. The hearts in propofol perfusion group (SOP, BDLP) were perfused for 40 min with K-H solution containing 25 μmol/L propofol. After the hearts became stable, the following indices were recorded: HR, left ventricular developed pressure (LVDP), ± dp/dtmax, etc. The contents of MDA and SOD activity were measured after perfusion. Results: After perfusion with K-H solution for 30 min, the basic indices of heart function of BDL group were significantly lower than those of SO group (P<0.05). The indices significantly decreased after perfusion with propofol (P<0.05), but the rates of change of all indices were not different between SO and BDL groups. The contents of basic MDA in BDL groups were significantly higher than those of SO groups (P<0.05); the basic SOD activities in BDL were significantly lower than those of SO groups (P<0.05). After propofol perfusion, MDA content of BDLP group significantly decreased (P<0.05) and SOD activity significantly increased (P<0.05). Conclusion: Propofol at clinical concentration shows no significantly different effects on isolated working heart function of rats with and without obstructive jaundice, which might be related to the fact that propofol can protect SOD activity, lower MDA content and improve the metabolism of myocardial.

Bronchoalveolar Lavage ; Bronchopulmonary Dysplasia ; etiology ; therapy ; Humans ; Infant, Newborn ; Infant, Premature ; Infant, Very Low Birth Weight ; Intubation, Intratracheal ; adverse effects ; Male ; Positive-Pressure Respiration ; Respiratory Insufficiency ; etiology ; therapy ; Treatment Outcome

Electrocardiography ; Female ; Fetal Hypoxia ; complications ; Humans ; Infant, Newborn ; Myocardial Infarction ; etiology ; therapy ; Myocardium ; metabolism ; pathology ; Treatment Outcome

Objective To investigate the relationship between optic d isc hemorrhage and localized retinal never fiber layer defects (RNFLDs) in norma l-tension glaucoma. Methods In 83 patients with normal-tensi on glaucoma, the cumulative frequency and quadrantal distribution of optic disc hemorrhages were retrospectively analyzed. The neighboring relation between opti c disc hemorrhages and RNFLDs in a same quadrant and the changes of correspondin g retinal never fiber layer (RNFL) after the occurrence of optic disc hemorrhage s were observed by tridimensional photochromy of ocular fundus. Results (1) The occurrences and distribution of optic disc hemorrhages: 29 of 83(34.94%) patients (33 eyes) had totally 58 occurrences, including 39 in infer iotemporal area, 14 in superiotemporal area, and 5 in other area. (2) The relati onship of neighborhood between optic disc hemorrhages and RNFLDs: in the availab le tridimensional photochrome, 23 occurrences in 15 patients (16 eyes) were foun d with cuneiform RNFLDs in the same quadrant, in which 22 was near the border of cuneiform RNFLDs. (3) The changes of corresponding retinal never fiber layer (R NFL) after the occurrence of optic disc hemorrhages: the photochromes of 24 occu rrences in 20 patients (21 eyes) were kept well in the initial and the 2-year f ollow-up periods, while the changes of RNFL were found in each region correspon ding to the 19 occurrences (in inferiotemporal or superiotemporal area) in the i nitial photochrome, including 7 cuneiform defects with various sizes, and 12 dev eloped localized RNFLDs next to the initial hemorrhages in the optic disc. No ob vious localized RNFL corresponding to the other 5 occurrences (1 in inferiotempo ral, 1 in superiotemporal, and 3 in other areas) were found in the follow-up pe riod. Conclusion Optic disc hemorrhages in normal-tension gla ucoma occur mostly in inferiotemporal area, and secondly in superiotemporal area of optic disc, and the appearance of optic disc hemorrhages may suggest that th e localized RNFLDs would develop in the associated regions.

Objective: This work studied platelet-neutrophil aggregates (PNA) expression in patients with acute ST-segment elevation myocardial infarction (STEMI). Methods: Our research included in 2 groups: STEMI group, n=40 patients admitted in our hospital and Control group, n=30 normal subjects. Blood levels of PNA, platelet-monocyte aggregates (PMA) and platelet-lymphocyte aggregates (PlyA) were measured by lfow cytometry at admission and the results were compared between 2 groups. Results: Compared with Control group, STEMI group had similar blood levels of PlyA and PMA,P=0.245 andP=0.312; while increased blood level of PNA,P<0.05. Correlation analysis showed that platelet-leukocyte aggregates (PLA) level was positively related to CK-MB (r=0.4992,P<0.01) and cTnI (r=0.4365,P<0.01). Conclusion: Blood level of PLA, especially PNA was significantly higher in STEMI patients which suggested that increased PNA might be sued as a new index for AMI diagnosis in clinical practice.

Objective:To explore the diagnostic value of treadmill exercise test (TET)and its Duke score in menopa-usal female patients with coronary heart disease (CHD).Methods:A total of 102 menopausal female patients re-ceived TET and coronary angiography (CAG)examination.With CAG as control,accuracy indexes etc.of TET combined Duke score diagnosing coronary artery disease in these patients were compared and analyzed.Results:Compared with single application of TET or Duke score,there were significant rise in specificity (27.12% vs. 30.50% vs.44.44%),positive predictive value (47.56% vs.46.75% vs.54.55%),negative predictive value (80%vs.72% vs.90.91%)and accuracy (53.92% vs.52.94% vs.64.94%)diagnosing CHD by TET combined Duke score both positive and negative,P <0.05 all;but there was no significant difference in sensitivity,P >0.05 both. There was no significant difference in CHD diagnosis between single use of TET and Duke score,P >0.05 all.Con-clusion:False positive rate of treadmill exercise test is higher in menopausal women.Treadmill exercise test com-bined Duke score is helpful to improve specificity,positive predictive value,negative predictive value and accuracy of the test.

Objective To evaluate the therapeutic effect of tulobuterol tape on mild or moderate bronchial asthma in children less than three years old . Methods Sixty-two children with mild or moderate asthma were randomized to receive either tulobuterol tape(treatment group) or procaterol hydrochloride tablet(control group) on the basis of inhaled fluticasone propionate for 2 weeks. Symptom scores of asthma, frequencies of episode of wheeze, doses of inhaled ventolin as rescue drug and the incidence of adverse reactions were recorded. Results In the treatment group,the symptom scores during daytime in the treatment group were (2. 2 ±0. 9)/week and (0. 9 ±0. 5)/week after 1 and 2 weeks of treatment, respectively, which were significantly lower than that in the control group(3.4 ± 1. 1)/week and (1. 3 ± 0. 6)/week after 1 and 2 weeks of treatment, respectively) (P < 0. 05). The symptom scores during night in the treatment group was significantly lower than that in the control group after one week of treatment (1. 8 ± 0. 7) /week v. s. (3. 3 ± 0. 9) /week, P < 0. 05). The frequencies of episode of wheeze was significantly different between the two groups (2. 3 ±1.2 and 3. 6 ± 1.3 in the treatment and control groups, respectively (P < 0.05) .The doses of inhaled ventolin in the treatment group (2. 6 ±0.9 spray/week) was significantly lower than that in the control group (3.7 ± 0. 8) spray/week) (P < 0. 05). The incidence of adverse reactions in the treatment group was significantly lower than that in the control group (3. 12% v. s. 23. 33% ,x2 = 3. 89,P<0.05). Conclusions Tulobuterol tape is a safe and effective medication for the treatment of mild or moderate bronchial asthma in children less than three years old.

Objective: To explore the relationship between endogenous estrogen level and myocardial no-reflow after reperfusion in postmenopausal acute ST-elevation myocardial infarction (STEMI) patients. Methods: A total of 100 postmenopausal STEMI patients with percutaneous coronary intervention (PCI) were enrolled and divided into 2 groups: Reflow group,n=77 and No-reflow group,n=23. Myocardial no-reflow was defined by TIMI≤2 grade or TIMI 3 grade and MBG≤2 grade after PCI. Blood levels of endogenous estrogen were examined before PCI; the relationship between endogenous estrogen level and myocardial no-reflow was assessed by Logistic regression analysis. Results: Compared with Reflow group, No-reflow group showed increased blood levels of estrone, estradiol, high sensitivity C-reaction protein (hs-CRP),P<0.05 and decreased sex hormone binding globulin (SHBG),P<0.05. Univariate analysis indicated that the length of lesion, thrombus score≥4, blood levels of estrone, estradiol and hs-CRP were positively related to no-reflow occurrence,P<0.05. Multi Logistic regression analysis presented that thrombus score≥4 (OR=4.994, 95%CI 1.987-10.518,P=0.035) and estradiol level (OR=4.091, 95% CI 1.105-8.582;P=0.046) were the independent risk factors for no-reflow occurrence. Conclusion: High blood level of endogenous estrogen was positively related to myocardial no-reflow after PCI in postmenopausal STEMI patients, which implied that endogenous estrogen might be the independent risk factor for no-reflow occurrence.