The anemia of chronic disease is chronic infection, inflammation, a class of cancer-related anemia syndrome, anemia in patients with malignant tumors often. In recent years recombinant human erythropoietin, widely used in clinical treatment of anemia, Especially in cancer-related anemia treatment achieved remarkable results, a blood transfusion to avoid the many adverse effects and improve the patient' s quality of life. A control chemotherapy-induced anemia is an important choice. Therefore, rhEPO on cancer-related anemia treatment mechanism has also become a research hotspot.

Objective: To study the clinicopathologic properties of hippocampus glioma with temporal lobe epilepsy(TLE) as the main manifestation. Methods: The clinical data of 6 patients with TLE and hippocampus masses were retrospectively analyzed. The 6 patients included 2 males and 4 females, with the longest history of epilepsy being 4 years. Results: All the 6 patients were surgically treated and were pathologically confirmed to have gliomas, including one angiocentric glioma( AG), one pilocytic astrocytoma (PA) with mucous degeneration, one astrocytoma, one oligoastrocytomao, one oligodendroglioma and one glioblastoma. Glial fibrillary acidic protein(GFAP) was strongly positive in all cases. Epilepsy disappeared after surgery in 5 cases; one patient had recurrence and received a second operation. Conclusion: Hippocampus gliomas with TLE as the main manifestation are usually low-grade gliomas of various types, and operation can obtain satisfactory prognosis.

Adult ; Cytokines ; metabolism ; Female ; Gene Expression ; Humans ; Interleukin-2 ; blood ; Interleukin-4 ; blood ; Male ; Semaphorins ; genetics ; metabolism ; T-Lymphocytes, Helper-Inducer ; metabolism ; Thrombocytopenia ; genetics ; metabolism

Adult ; Audiometry, Pure-Tone ; Case-Control Studies ; Evoked Potentials, Auditory, Brain Stem ; Hearing Loss, Noise-Induced ; diagnosis ; physiopathology ; Humans ; Male ; Middle Aged ; Noise, Occupational

Hematology ; Humans ; Integrative Medicine

Anemia, Aplastic ; drug therapy ; Animals ; Drugs, Chinese Herbal ; therapeutic use ; Humans ; Leukemia, Myeloid, Acute ; drug therapy ; Medicine, Chinese Traditional ; Phytotherapy ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; drug therapy ; Purpura, Thrombocytopenic, Idiopathic ; drug therapy

Objective:To observe clinical and pathological features of pancreatic solid-pseudopapillary tumor ( SPPT) , and to find some useful immunohistochemical methods for its differential diagnosis.Methods: The clinical features of 14 SPPT patients were obtained. Each case underwent microscopic observation and immunohistochemical staining. The primary antibodies were CgA, Syn, E-cadherin, β-catenin and Cyclin Dl. These results were compared with 5 pancreatic well-differentiated tumors and well-differentiated carcinomas ( WET/WEC). Results: SPPT mainly involved young women, and the head of pancreas was the commonest location. Tumors were always in solid and cystic gross appearance.Although the tumor' s borderlines seemed clear, focal infiltrations could often be identified. The histological features of SPPT were similar in some aspects to those of WET/WEC, especially the solid pattern of WET/WEC. Both of them could express CgA and Syn. But all SPPTs lost E-cadherin membranous signals, and even had some nuclear signals (5/14) , while all WET/WECs remained the same staining pattern with normal pancreas cells, β-catenin positive signals in SPPTs were located both in nuclei and plas mas. WET/WECs' positive signals were all in membranes and plasmas, but negative ones in nuclei. Perinuclear dot-like signals could also be seen in the majority cells, which were similar to normal islet cells' staining pattern. SPPTs' nuclear positive rates of Cyclin Dl were usually more than 70% (12/14). WET/WECs' rates were all lower than 30%. Conclusion: Comprehensive analysis of patients'clinical, pathological features and immunohistoehemistry results, including E-cadherin, β-catenin and Cyclin Dl, was helpful to the diagnosis of SPPT and its differential diagnosis of WET/WEC.

Human tumor antigen elicit a cell-mediate immune response in the host have been identified. In this study, a pancreatic cancer cell line SW1990 associated apomucin was examined for the induction of tumor draining lymph node cells(TDLN) anti-tumor immune responses.The TDLN of patients with breast cancer(4 cases), gastric cancer(3 cases), colon cancer(3 cases) were isolated, cocultured with apomucin 50 ?g/ml and low dose rhIL-2 50U/ml in vitro, the cytolytic effects were measured by MTT assay. The results showed that: the proliferated lymphocytes can lysis LS174T colon cancer cells, KATO-Ⅲ gastric cancer cells, SW1990 pancreatic cancer cells and K562 leukemia cells. The most cytolytic effects were higher than LAK. This results might provide a rational basis for future attempts to elicit and manipulate apomucin vaccine for active specific immunotherapy or adoptive immunotherapy for adenocarcinoma.

90 KD.A11 the five monoclonal antibodies against this apomucin reacted with cancer cell lines and cancer tissues,while only one also reacted with normal tissues.

Through several years practice of bilingual education,we have established the bilingual teaching model with its own characteristics,which in cludes the selection of materials,the choice of teaching methods,improvement of teaching methods and means on several aspects.We have also made some reflection and study of the existing problems and future improvement of pharmacology bilingual education.