Strontium-89(89Sr)therapy has been recognized as an effective method for treating bone metastases. It functions as a calcium analog that binds with collagen matrix produced by the MC3T3-E1 cells during collagen mineralization. 89Sr emits pure β rays which palliate bone pains and reduce the number of new metastasis sites. Response to 89Sr is affected by factors such as the location, size and histological type of lung cancer, the type of metastasis and the duration of treatment, and can be predicted by relief of bone pain, elimination of metastasis, CD4 +/CD8 +, ALP, and others. 89Sr therapy is safe and effective. Repeat administration or combined used with other treatments can improve the therapeutic effect of 89Sr.

Objective To explore the clinical features,treatment methods and effects of late-stage burned complicated with stress ulcer.Methods The clinical data of 206 burned patients were retrospectively analyzed,and the clinical features,treatment methods and effects of burned patients complicated with stress ulcer were analyzed.Results In 206 patients,there were 42 late-stage burned patients complicated with stress ulcer(20.4％),of which 34 cases were cured(81.0％),8 cases died(19.0％) (3 cases died of stress ulcer bleeding,5 cases died of stress ulcer bleeding complications).Conclusion The probability of late-stage burned complicated with stress ulcer is high and dangerous.For the patients with late-stage burned patients complicated with stress ulcer,early enteral nutrition,gastric mucosal protection,wound sepsis to prevent wound infection,the treatment measures should be effectively put into practice,which will be good for making patients stable,and then the patients can be cured.

Objective :To establish a simple, reproducible brain edema model induced by endotoxin in infant rats and explore the role of intracellular free calcium and calmodulin (CaM). in the development of brain edema. Methods: A total of 45 infant rats were divided randomly into endotoxin treated( n = 36) and control( n = 9) group. The animals were intraperitoneally injected with 10mg/kg of endotoxin or saline respectively. The brain tissue intracelluar free [Ca2 + ] as well as the expression of CaM was detected by fluorescence and protein hybridizaton methods respectively. The tissue water content,Evans Blue content and pathology under electronic microscope were also observed. Results:Brain water and EB content were remarkably increased in endotoxin treated animals compared with those in the control, in which the intracellular free [Ca2+ ] was also significantly increased and the expression of CaM up - regulated. Electron microscopic studies revealed that the blood - brain barrier(BBB)was disrupted with neuronal degeneration,neurogliocyte swelling and necrosis. Conculsion :These results suggest that LPS increases the intracellular free [Ca2+ ] ,and activates the CaM - dependent function via Ca2+ /CaM pathway,which might relate to the increased BBB permeability and brain edema formation.

OBJECTIVE To study the influence of enzyme detergent for improving the quality during the cleaning of medical instruments.METHODS The 360 pieces of contaminated instruments for manually cleaning were divided into two groups with 180 pieces each, one group as test one immersed in Lionser enzyme solution 5 minutes at 1∶200 and another one as control immersed in non-enzymatic detergent 30 minutes at 1∶200.Eventually flush all instruments using free water.RESULTS Significant difference(P

ObjectiveTo observe the effect of Sanfeng Rougan Tang on the type of Ganyang Shangkang essential hypertension.Methods42 essential hypertension patients in type of Ganyang Shangkang Zhen were treated with Sanfeng Rougan Tang. The anti-hypertension medicine remained if the patient had taken. The blood pressure and symptoms of the patients was recorded before and a month after treatment.ResultsAfter treatment, the blood pressure and clinical symptoms of the patients had been significantly improved. The ratio of the blood pressure control was 95.2%, and of the primary symptoms control was 94.4%.ConclusionSanfeng Rougan Tang is effective on the type of Ganyang Shangkang essential hypertension.

ObjectiveTo investigate the effect of psychological intervention on quality of life (QOL) of patients with mammary carcinoma.Methods64 patients with mammary carcinoma were divided into intervention group (n=36) and control group (n=28), and psychological status and QOL of patients of two groups were analyzed after treatment.ResultsThe psychological status and QOL of intervention group was better than that of control group (P<0.05～0.001).ConclusionThe psychological intervention in full stage being in hospital can improve QOL of patients with mammary carcinoma, and it is clinically significant to improve cure rate and survival rate of patients.

Objective To compare the clinical effects of low-temperature plasma ablation combined with adenoidectomy and decolle-ment in the treatment for patients with sleep apnea syndrome.Methods Totally 68 patients with sleep apnea syndrome who underwent elec-tive surgical treatment in our hospital from June 2013 to February 2015 were selected as the study objects.According to the order of treat-ment,the patients were randomly divided into the control group and the observation group,with 34 cases in each group.The control group were treated by routine decollement.The observation group were treated by low-temperature plasma ablation combined with adenoidectomy.After operation,the 2 groups were followed up for 6 months.The improvement effects of different operative methods in clinical symptoms and prog-nosis of patients with sleep apnea syndrome were compared.Results The total effective rate in the observation group (97.06%)was higher than that in the control group (82.35%),and the difference was statistically significant (P <0.05).The postoperative VAS pain grading of the observation group was relatively lower.The normal proportion (50.00%) was significantly higher than that in the control group (11.76%).Patients with moderate and severe pain in the control group accounted for 44.12% and 14.71% respectively,which were signif-icantly higher than those in the observation group(P <0.05).The incidence of postoperative bleeding in the observation group(2.94%)was significantly lower than that in the control group while the incidence of fever was higher than that in the control group (P <0.05).After oper-ation and at the end of the follow-up,OSA-18 score of the observation group decreased significantly and were (46.66 ±7.87)and (33.47 ± 10.59)respectively.The decreased range was greater than those in the control group (P <0.05).Conclusion To adopt low-temperature plasma radiofrequency ablation combined with adenoidectomy in the treatment of patients with sleep apnea syndrome can improve the surgical treatment effect,reduce postoperative pain,reduce the incidence of postoperative bleeding,optimize patients’quality of life and improve the prognosis.

[Summary] Glucose homeostasis is precisely regulated by glucagon of pancreaticαcell and insulin ofβcell secretion.Diabetes is a chronic disease characterized by insulin deficiency or insulin resistance (IR). Absolute or relative excess of glucagon secretion may play an important role in the development of diabetes.Previously more studies on the functions of islet βcells were reported,but less on islet αcells. There are a variety of factors involved in the regulation of glucagon secretion,such as nutrients,endocrine hormones and neurotransmitters. High fasting and postprandial blood glucose in patients with diabetes are associated with increased glucagon.Isletαcell dysfunction is closely related to the development of diabetes and the ability of responding to hypoglycemia.Further studies of α cell function and its role on the development of diabetes could provide insight into the treatment of diabetes.

OBJECTIVE:To provide reference for definition and research & development of new drugs in China.METHODS:The history of the definition for new drugs was reviewed,and the effects of the definition of new drugs on the research and development of drugs were discussed by using the game theory "Tragedy of the Commons" and "Anti-Tragedy of the Commons".RESULTS & CONCLUSIONS:The definition of new drugs should be more and more scientific and reasonable and in line with the aim of building new creative country,meanwhile,efforts should be paid to avoid the above mentioned two kinds of tragedies.

OBJECTIVE:To observe long-term efficacy of intensive rosuvastatin therapy in the treatment of acute coronary syn-drome (ACS) and explore its possible mechanism,so as to provide reference for clinical diagnosis and treatment. METHODS:ACS patients receiving rosuvastatin after cured in our hospital during Jan. 2013-Jan. 2015 were divided into observation group(55 cases)and control group(47 cases)according to the dose of rosuvastatin. Under same guidance of physicans,2 groups were addi-tionally given Rosuvastatin calcium tablets(20 mg for observation group,10 mg for control group,qd,po)orally on the basis of routine treatment. Both groups were treated for 1 year. The incidence of 1-year accumulative main adverse cardiac event (MACE) were compared between 2 groups as well as the levels of blood lipid and serum cytokines,the occurrence of ADR before treat-ment,after 3 months of treatment. RESULTS:The incidence of accumulative MACE in observation group was significantly lower than control group,with statistical significance (P<0.05). After treatment,the levels of TC and LDL-C in 2 groups were de-creased significantly;the level of LDL-C was inCreased significantly compared to before treatment,and the observation group was significantly lower than the control group,with statistical significance(P<0.05). The levels of IL-1β and TNF-α in 2 groups were decreased significantly (P<0.05);the observation group was significantly lower than the control group,with statistical signifi-cance (P<0.05). The peripheral blood LDL-C was positively correlated with IL-1β and TNF-α in observation group after treat-ment,with statistical significance(P<0.05). There was no statistical significance in the incidence of ADR between 2 groups(P>0.05). CONCLUSIONS:Intensive rosuvastatin therapy can significantly improve the long-term prognosis for ACS patients,which may associate with lipid metabolic regulation and anti-inflammatory effect.