Gastric cancer incidence and morality are high,and its comprehensive treatment of gastric cancer has a major significance in clinical.Riboflavin is a water-soluble vitamin,absorbed by riboflavin transporter protein,which can perform anti-tumor function by inhibiting tumor cell prolifiration and inducing promoting apoptosis.Riboflavin plays importan roles in gastric cancer development,treatment,cancer invasion,metastasis and reducing the adverse effects of chemotherapy.Studying on mechanism and biological characterristic of riboflavin may help to develop more specific individualized treatment plans for the patients with gastric cancer in the future.