This is a case of 34-year-old female Gravida 1 Para 1 37 weeks age of gestation and has been diagnosed as a case of Extraskeletal Ewing Sarcoma, Right Axillary Mass Grade 3 during the first trimester. Patient had received 4 cycles of Doxorubucin as part of the "Bridging Therapy" and Chemotherapeutic regimen. Chemotherapy has been pursued to this patient, initiated on the 21st week of gestation with hopes to decrease the size of the mass and alleviate the pain during the course of pregnancy. The ethical and therapeutic concerns for both the patient and the physician remains to be a challenge up to this course. A multidisciplinary approach was instigated to weigh risks versus benefit for the expecting mother and the unborn child.
Neoplasms ; Drug Therapy

Neuroendocrine carcinoma (NEC) of the endometrium is a rare, aggressive subtype of endometrial cancer. We report a 61-year-old female with a history of breast cancer, s/p modified radical mastectomy, chemotherapy, radiotherapy and hormonal (tamoxifen) therapy, who presented with post-menopausal bleeding. Patient underwent TAH-BSO with lymph node dissection, and was diagnosed with a mixed small cell neuroendocrine carcinoma (SCNEC) and large cell neuroendocrine carcinoma (LCNEC), confirmed by positive immunohistochemical staining for neuroendocrine markers. No other lesions were identified on PET-CT, making a primary endometrial NEC the most likely diagnosis. We review the clinical and pathologic characteristics of endometrial neuroendocrine carcinomas.
Endometrial Neoplasms ; Carcinoma, Neuroendocrine ; Carcinoma, Large Cell ; Carcinoma, Small Cell