The efect of some types of exercise on systolic pressure was studied. The results were as follows.
1. Increased rate of systolic pressure immediately after run of eight distances was greatest in 100 meter run. Such a high level was also observed in both 400 and 1, 500 meter runs.
Further prolongation of the distance, however, induced a sharp reduction of increased rate to 5, 000 meters and in a run of still longer distance the above tendency was weakened.
2. If these results are applicable to the change of systolic pressure during a prolonged exercise, Edward's graphic representation seems to be true. Some of our experiments, however, indicated that Edward's curve was not the only case.
Some features often expected were the following.
a) Generally, the final rise was low if the initial rise was low.
b) However, the final rise would be high in the cases with a faster finish even if the initial rise was low.
c) In general, the final rise was high if the initial rise was high.
d) However, the final rise would be lowering as development of exhaustion even if the initial rise was high, and only this form was considered to analogize with Edward's curve.
3. Blood pressure was determined during short interruption of exercise in 10, 000meter run. The lap time was estimated immediately before the determination of pressure.
Since there was a strong statistical correlation between the increased rate of systolic pressure and the lap time (r=0.698, P<0.01), the fall in systolic pressure increased at early stage in a long continued exercise was supposed to be induced by decreased pace.
Therefore, decreased severity of exercise may be a major factor inhibiting increase of pressure during prolonged exercise. It is undeniable that this type brought about by in-hibiting pressor effect is angmented by some nervous or humoral factors.
4. The longer the distance, the earlier the subnormal phase after exercise tends to start and the deeper the drop of systolic pressure will become.
In all of the four prolonged runs over 5, 000 meters was observed average drop below normal of about 20 per cent and the lowest value of 28 per cent except two cases indicating marked fall. Futhermore, average fall below normal in mean arterial pressure induced after increased pressure by epinephrine was 30 per cent in rabbits. These data showed that in subnormal phase there may be a certain lower limit to sink and that the existense of this protective line of defence would prevent deterioration of the circulation.
5. The systolic pressure rised in the trained higher than in the untrained immediately after a short and sharp effort, but in the former the reduction of the rise with longer distance of run was more slight than the latter.

　　In recent years, favorable therapeutic outcomes have been reported for arterial injection chemoradiotherapy for tongue cancer. The present case involves an 80-year-old woman in our palliative care department who had high-grade, advanced tongue cancer. Because there was a request for surgery to prevent airway occlusion due to growth of the tumor, she was referred to our department in April 2009. As a treatment policy for controlling tumor growth in high-grade, advanced tongue cancer, arterial injection chemoradiotherapy was carried out through the superficial temporal artery, with a tongue artery catheter in place on both sides. Therapeutic effect was obtained, and it was possible to avoid airway occlusion through tumor regression. Dysphagia and dysphemia were improved, which in turn improved quality of life. In this case, there was an opportunity to carry out multidisciplinary team medicine, including support from the oral care and palliative care teams as part of the process of cancer therapy. Here, we present our findings in this case.

BACKGROUND: Atopic dermatitis (AD) in infants is often related to food allergies (FA). The beneficial effects of lactic acid bacteria towards allergic diseases have been reported, but there are few reports on their effect and preferable dosages on AD in young children with concomitant FA. OBJECTIVE: To examine additional effects of two different dose of paraprobiotic Lactobacillus acidophilus L-92 (L-92) on the clinical treatment in young children afflicted by AD with diagnosed or suspected FA. METHODS: Fifty-nine AD young children from 10 months to 3 years old, with FA or who had not started to ingest specific food(s) because of high specific IgE levels, were recruited and randomly allocated into L-92 group (daily intake of 20 mg L-92/day) and placebo group. Participants were given test sample with conventional treatment for AD over a 24-week period. The severity of eczema was evaluated using SCORing Atopic Dermatitis (SCORAD) index before intervention, and at 4, 12, and 24 weeks after intervention. RESULTS: After 24 weeks of intervention, a significant decrease in SCORAD was observed only in the L-92 group when compared with the baseline values. Significant decreases in thymus and activation-regulated chemokine (TARC) and total IgE were also detected 24 weeks after intake in the L-92 group compared with the placebo group. CONCLUSION: It was suggested that intake of sufficient amounts of L-92 works as an adjunctive treatment of young children afflicted by AD with diagnosed or suspected FA.
Bacteria ; Chemokine CCL17 ; Child ; Dermatitis, Atopic ; Eczema ; Food Hypersensitivity ; Humans ; Immunoglobulin E ; Infant ; Lactic Acid ; Lactobacillus acidophilus ; Lactobacillus

OBJECTIVE: To validate the relationship between residual walking ability and monthly care cost as well as long-term care insurance (LTCI) certification level in elderly patients after surgical treatment for hip fractures in Japan. METHODS: Elderly patients aged >75 years who underwent surgical treatment for hip fractures in our hospital were included. The preand post-surgical (6-month) walking ability and LTCI certification and the presence or absence of dementia was determined from medical records and questionnaires. Walking ability was classified into 6 levels used in our daily medical practice. Based on these data, we correlated the relationship between walking ability and the LTCI certification level. Further, based on the official statistics pertaining to the average monthly costs per person at each LTCI certification level, we evaluated the relationship between walking ability and monthly care cost. RESULTS: A total of 105 cases (mean age, 80.2 years; 16 men; 39 patients with dementia) were included. The correlation between walking ability and average monthly cost per person as well as LTCI certification level at 6 months postoperatively (r=0.58) was demonstrated. The correlation was found in both groups with and without dementia. CONCLUSION: The ability to walk reduced the cost of care in elderly patients who experienced hip fracture, regardless of the presence of dementia.
Aged* ; Certification ; Cost-Benefit Analysis ; Dementia ; Hip Fractures* ; Hip* ; Humans ; Insurance, Long-Term Care ; Japan ; Long-Term Care ; Male ; Medical Records ; Mobility Limitation ; Walking*