We investigated the effects of the Chinese prescription “Shosaiko-To and Inchinko-To” on the liver function after releasing of obstructive jaundice on rats.
On control group, the values of GOT, GPT, T-Bil and ALP were recovered to the values before obstructive jaundice on 14th day after releasing of obstructive jaundice.
On the other hand, on the Shosaiko-To and Inchinko-To treated group, the values of GOT, T-Bil and ALP were significantly improved on 3rd or 5th day after releasing of obstructive jaundice (p<0.001, vs control).
The prescription of Shosaiko-To and Inchinko-To after releasing of obstructive jaundice indicated the prompt improvement for bile stagnation hepatitis.

Adrenal venous sampling (AVS) is the key procedure for lateralization of primary hyperaldosteronism (PA) before surgery. Identification of the adrenal veins using computed tomography (CT) and intraoperative cortisol assay facilitates the success of catheterization. Although administration of adrenocorticotropic hormone (ACTH) has benefits such as improving the success rate, some unilateral cases could be falsely diagnosed as bilateral. Selectivity index of 5 with ACTH stimulation to assess the selectivity of catheterization and lateralization index (LI) >4 with ACTH stimulation for unilateral diagnosis is used in many centers. Co-secretion of cortisol from the tumor potentially affects the lateralization by the LI. Patients aged <35 years with hypokalemia, marked aldosterone excess, and unilateral adrenal nodule on CT have a higher probability of unilateral disease. Patients with normokalemia, mild aldosterone excess, and no adrenal tumor on CT have a higher probability of bilateral disease. Although no methods have 100% specificity for subtype diagnosis that would allow bypassing AVS, prediction of the subtype should be considered when recommending AVS to patients. Methodological standardization and strict indication improve diagnostic quality of AVS. Development of non-invasive imaging and biochemical markers will drive a paradigm shift in the clinical practice of PA.