Introduction: This study aimed to compare coping strategies in children of parents deceased from cancer and children of parents healed from cancer in the city of Shiraz, Iran. Methods: One-hundred and fifteen people [58 children of parents healed from cancer and 57 children of parents deceased from cancer] were recruited in this study via a convenience sampling method. Coping Inventory for Stressful Situations was used to measure different types of coping strategies [task-oriented coping strategy, emotion-oriented coping strategy, and avoidance coping strategy]. Conclusion This study highlights the importance of coping strategies in families with a cancer parent which demands the importance of teaching appropriate coping strategies in order to reduce the adverse consequence of cancer in the family.