As far as we are aware of, we report the fi rst documented case of a 51-year-old Filipino female with
multifocal motor neuropathy who presented with
asymmetric weakness, unusually in the lower extremity, and confi rmed with anti-GM1 antibody.
The treatment of intravenous immunoglobulin with
a total dose of 2 g/kg was initiated and repeated every two months with noticeable improvement
based on electromyography and nerve conduction
studies.
Apart from the unreported Filipino case of multifocal motor neuropathy substantiated by features
in clinical, electrophysiologic, antibody testing and
response to immunotherapy, the unique occurrence
in a female and involving the lower extremity in this
rare disorder deserve this present documentation.
Multifocal motor neuropathy is seen more in males
with a ratio of 2.7:1. It is described as a pure motor
disease without sensory defi cits and predominantly
affects the upper extremities. The diagnosis for the
disorder is supported by determination of ganglioside GM1 antibodies.
Immune System Diseases
;
Polyneuropathies