A total of 336 patients suspected of having allergic contact dermatitis underwent patch testing at our institution from August 2000 to February 2005 using the European Standard Series by Chemotechnique Diagnostics composed of 25 allergens. The cutaneous lesions were located on the hands (46.2 percent), feet (29.1 percent), arms (25.5 percent), legs (21.0 percent) and trunk (15.9 percent). Patch test results showed that 303 (90 percent) had one or more positive patch test reaction. The most frequent positive reactions were to nickel sulfate (42 percent), potassium dichromate (30.7 percent), cobalt chloride (25.5 percent), parabens (22.5 percent) and fragrance mix (18.65 percent) while the least frequent were Tixocortil-21-pivalate (33 percent), Quarternium -15 1.0 percent pet (3 percent), Budesonide (2.7 percent) and Quinolone mix 6.0 percent pet (2.7 percent). In this study the most frequent relevant sources for nickel sulfate were keys/keychains, costume jewelry, coins and watches. For potassium dichromate the top sources were adhesives, detergents and leather. The most common sources for cobalt chloride were zippers/buttons and jewelry. For parabens the relevant sources were food products and cosmetics while for fragrance mix these were cosmetics and fragrances.

Human ; Male ; Female ; Aged ; Middle Aged ; Adult ; Adolescent ; Child ; Child Preschool ; Allergens ; Budesonide ; Cobalt ; Dermatitis, Allergic Contact ; Patch Tests ; Quinolones

Human ; Male ; Female ; Infant ; Breast Feeding ; Dermatitis, Atopic ; Milk, Human ; Wound Healing ; Eczema

Fusidic Acid

Dyskeratosis Congenita ; Dermoscopy

Introduction: Extramammary Paget’s disease (EMPD) is a rare cutaneous slow growing tumor seen in areas rich in apocrine glands such as the anogenital region while ectopic EMPD is defined as EMPD arising on non-apocrine areas. The pigmented variant of EMPD is a very rare finding, with only a few reported cases, and can be misdiagnosed as melanoma. Case report: We report a case of a 74-year-old woman who presented with a four-year history of pruritic, non- healing erythematous plaques located on the right axilla and left lower abdomen. Histopathology revealed acanthotic epidermis with atypical keratinocytes that was negative for anti S-100 and Melan-A and was positive for carcinoembryonic antigen (CEA), cytokeratin (CK), CK 7 and epithelial membrane antigen (EMA). Patient was managed as pigmented and ectopic variant of extramammary Paget’s disease. Several tests and imaging were done to rule out malignancy. Wide excision with axillary node dissection, bilateral inguinal node dissection, frozen section biopsy and reconstruction using right pectoralis major musculocutaneous flap, split thickness skin graft with left inguinohypogastric drain were done by reconstructive surgery. Frozen section biopsy was negative for S-100, MELAN-A and HMB-45, ruling out malignant melanoma. Patient followed up every month for 6 months after the procedure with no recurrence and lymphadenopathy. Conclusion This case emphasizes that extramammary Paget’s disease is not a preventable disease and early diagnosis is the key to a favorable diagnosis. Any unilateral eczematous lesion that does not respond to an appropriate course of topical treatment warrants a skin biopsy.
Melanoma ; Immunohistochemistry

Introduction: Acne vulgaris is a common dermatologic disorder caused by follicular epidermal hyperproliferation, excess se- bum production, inflammation, and Cutibacterium acnes (C. acnes). The mangosteen fruit rind contains large amount of xantho- nes, which has high antimicrobial activity against C. acnes. Objectives: To compare the efficacy and safety of mangosteen 1% extract gel versus benzoyl peroxide (BPO) 5% gel in the treat- ment of mild to moderate acne vulgaris. Methods A total of 60 participants with mild to moderate acne or a rating of 2 or 3 in the Investigator’s Global Assessment (IGA) for acne were randomized to receive either mangosteen 1% extract gel or BPO 5% gel applied on the face twice daily over an 8-week period. Primary outcomes measured in the study were clinical remission graded as “clear” or “almost clear” (rating of 0 or 1) based on the IGA and any adverse reaction.
Acne Vulgaris ; Benzoyl Peroxide

Harlequin ichthyosis (HI) is a rare type of congenital keratinization disorder that, when left untreated, usually leads to early neonatal demise. A clinical diagnosis of HI is considered when a patient presents with thick plate-like scaling of the skin together with eclabium, ectropion, and nasal hypoplasia. The diagnosis can be confirmed by genetic testing to determine mutation in the adenosine triphosphate-binding cassette A12 (ABCA12) gene. Early administration of systemic retinoids to promote desquamation and emollients to control excessive scaling and dryness of the skin lead to better prognosis in most cases of HI. We present the case of a 4-year-old male with HI who has been successfully managed with bland emollients and systemic acitretin therapy, which we started when he was 1 year old.
Acitretin

Harlequin ichthyosis (HI) is a rare type of congenital keratinization disorder that, when left untreated, usually leads to early neonatal demise. A clinical diagnosis of HI is considered when a patient presents with thick plate-like scaling of the skin together with eclabium, ectropion, and nasal hypoplasia. The diagnosis can be confirmed by genetic testing to determine mutation in the adenosine triphosphate-binding cassette A12 (ABCA12) gene. Early administration of systemic retinoids to promote desquamation and emollients to control excessive scaling and dryness of the skin lead to better prognosis in most cases of HI. We present the case of a 4-year-old male with HI who has been successfully managed with bland emollients and systemic acitretin therapy, which we started when he was 1 year old.
Ichthyosis, Lamellar