Background: Worldwide, smoking cessation interventions and clinic programs were set up to help smokers in seeking assistance and motivation to abstain smoking and eventually become tobacco-free. Objectives: To determine the outcomes and factors influencing outcomes of Southern Philippines Medical Center (SPMC) employees 6 months and 1 year after enrollment to SPMC Smoking Cessation Clinic (SCC). Methodology: SPMC employees enrolled to the program from the period of 2014 to 2017 with written informed consent to participate in the study. Demographic, clinical, and smoking profiles were gathered from the participant’s Smoking Cessation clinic medical record. A one-time interview was done to acquire additional information such as family genogram and Family Apgar Score at the SCC of SPMC. Main Results: This study had a target of 83 participants, but only 29 provided consent which gives a response rate of 34.93%. Majority of the participants are males, have mean age of 36 years old belonging to unattached young adults, nuclear family structure with highly functional Family Apgar scores and living with a mean of 3 family members per household. All participants had no co-morbidities present. The mean age started smoking is at 21 years old with a mean number of 6 cigarette sticks smoked per day and a mean number of 9 years smoking history. Almost all of the respondents were able to quit smoking within 6 months of enrollment to the program while a few have relapsed. All respondents quit after one year in the program. No significant factors identified during 6 months of enrollment and all respondents were able to quit after 1 year. Conclusion The study results showed that the Smoking Cessation Program established in SPMC was effective. Enrollment to the program for a minimum of six-month duration and with regular clinic sessions prove to be effective in increasing the participant’s readiness to quit and eventually becoming smoke-free.