G protein coupled receptors (GPCRs) have emerged as the most potential target for a number of drug discovery programs ranging from control of blood pressure, diabetes, cure for genetic diseases to treatment of cancer. A panel of different ligands including hormones, peptides, ions and small molecules is responsible for activation of these receptors. Molecular genetics has identified key GPCRs, whose mutations or altered expressions are linked with tumorgenicity. In this review, we discussed recent advances regarding the involvement of GPCRs in the development of cancers and approaches to manipulating the mechanism behind GPCRs involved tumor growth and metastasis to treat different types of human cancer. This review provides an insight into the current scenario of GPCR-targeted therapy, progress to date and the challenges in the development of anticancer drugs.

This study investigated the impact of online shopping addiction on compulsive buying behaviour and life satisfaction write among students which include both male and females from different cities of Pakistan. The purpose of the study was to find scientifically that whether online shopping addiction has impact on compulsive buying behaviour and life satisfaction or not. Research participants were 300 individuals, 150 males and 150 females with age range of 20 to 30 years. The study is quantitative in nature. Purposive sampling technique has been used. The online shopping addiction scale. Compulsive buying behaviour screening tool by maccarrone-eaglen and schofield in 2017 and the satisfaction with life scale by diener, emmons, larsen and griffin in 1985 were administered on the participants. To test the hypothesis, descriptive statistics, linear regression, Pearson bivariate correlation and t test, were used. The findings of present study highlights that online shopping addiction is strong predictor of compulsive buying behaviour and life satisfaction. It also indicated that online shopping addiction and compulsive buying behaviour are having significant positive correlation between them while online shopping addiction and compulsive buying behaviour have significant negative correlation with life satisfaction. The results also show that female students have higher score on online shopping addiction and compulsive buying behaviour while male students have higher score on life satisfaction. Hypothetical and actual results are closely related.