BACKGROUND: Kidney transplantation (KT) remains to be the preferred mode of renal replacement therapy as it offers the best clinical outcomes, a better quality of life, and lesser complications compared to dialysis. However, KT still carries a number of complications, one of which is graft thrombosis. Despite advancements in treatment, graft thrombosis is still an important cause of early graft loss. Prevention therefore, is of significance. A growing number of evidence suggests that low-dose aspirin has a role in the primary prevention of allograft thrombosis. RESEARCH QUESTION: Among renal transplant recipients, does postoperative aspirin prevent early renal allograft thrombosis? OBJECTIVE: To conduct a meta-analysis to determine the effect of postoperative aspirin on preventing renal allograft thrombosis. METHODS: A systematic search of PubMed, Google Scholar, CENTRAL, and clinicaltrials.gov was done by two independent authors. All randomized and non-randomized studies determining the effect of postoperative aspirin on renal vein/allograft thrombosis were reviewed for eligibility and quality assessment. Studies on both adult and pediatric kidney transplant recipients were included. RESULTS: Five non-randomized cohort studies (3 in adults, 2 in children) with a total of 2,393 patients were included. Using the Newcastle-Ottawa scale, two studies were found to have good quality, while three had poor quality. In a fixed-effects meta-analysis, aspirin was associated with a reduced risk for renal allograft thrombosis in adults (RR 0.13; 95% CI 0.06, 0.28;I2 22%) and children (RR 0.11; 95% CI 0.03, 0.40; I2 0%). CONCLUSION: Post-operative aspirin was associated with reduced risk for renal allograft thrombosis in both adults and children. However, the best available evidence is limited to observational studies. A well-designed randomized controlled trial is needed to confirm this finding.
Aspirin ; Kidney Transplantation ; Renal Veins ; Venous Thrombosis ; Transplantation, Homologous ; Kidney Diseases ; ; Veins ; Allografts

To explore the effect of social media burnout on loneliness and body image among university students in Pakistan. Current study was conducted in Riphah International University Islamabad, Pakistan and comprised of 306 university students including 152 male and 154 females with age range from 19-29 years. In-depth interviews were conducted with 20 students including 10 male and 10 females to explore the effect of social media usage on body image. Cross sectional research design was used in which quantitative and qualitative analyses were conducted. UCLA loneliness scale by Russell was used to assess loneliness. Multi-dimensional body self-relations scale by Cash was used to measure body image and social media burnout scale developed by Han was used to measure social media burnout. Findings indicate that there is a positive relationship between social media burnout and dissatisfaction with body image (r=0.175, p<0.01) and positive relationship exists between social media burnout and loneliness (r=0.187, p<0.01). There is also a positive relationship between loneliness and dissatisfaction with body image (r=0.314, p<0.01). Female students feel more exhausted by social media than male students (t=4.28, p<0.01). Loneliness and body dissatisfaction are found to be high in social media exhausted university students. Loneliness also leads to dissatisfaction with body image. Female university students got social media burnout more quickly than male students.