OBJECTIVE: This study aimed to determine the efficacy of methotrexate in preventing postmolar gestational trophoblastic disease (PMGTD) among patients with high-risk complete hydatidiform mole.

METHODS: This was a double-blind randomized controlled trial carried out from 2007 to 2013. A total of 99 patients with high-risk complete hydatidiform mole who underwent suction curettage were randomly allocated to either the treatment or control group. The treatment group received methotrexate while the control group received a vitamin B complex. The number of patients who developed PMGTD in each group was recorded. All tests of significance were carried out at a .05 alpha level of significance, 95% confidence interval.

RESULTS: There was no significant difference between the two groups in terms of age, gravidity, baseline ?hCG, age of gestation, and corpus size. The overall incidence of PMGTD was 27.9%. For the per protocol analysis, a total of 30 patients received chemoprophylaxis while 31 patients received placebo treatment. The total incidence of PMGTD was 16.67% for the treatment group and 38.71% for the control group. The computed risk ratio was 0.43 (95% C.I.: 0.17-1.07, p value = 0.07).

CONCLUSION: Results failed to reach statistical significance but the large fall-out rate may have significantly affected the outcome of the study. Methotrexate chemoprophylaxis may still be useful in preventing PMGTD, particularly in settings where the incidence of hydatidiform mole is high and there is high probability that patients will fail to follow the stringent ?hCG monitoring schedule after molar evacuation.

Human ; Female ; Adult ; Neoplasms

Abdominal pregnancy resulting in lithopedion is a rare condition constituting only 0.0054% of all pregnancies. This is a case of a 48-year-old Gravida 6 Para 3 (3-0-2-2) who consulted at the emergency room for an ultrasound finding of abdominal pregnancy. The patient had previous imaging done which showed a live intrauterine pregnancy until her fourth ultrasound, showing fetal death in utero. After several months without passage of the products of conception, a repeat ultrasound showed an abdominal pregnancy. Diagnosis of abdominal pregnancies may be difficult, thus it is important to utilize other imaging modalities to confirm the diagnosis. The mainstay for treatment for abdominal pregnancies is laparotomy. However, due to the possible severe hemorrhage that may arise intraoperatively, preoperative and postoperative arterial embolization of feeding vessels may be performed, as was done in the case discussed.
Pregnancy, Abdominal