In order to offer high standard and satisfactory medical servering,medical staff should learn patients' characteristics at first,including patients' roles,pains,requirement,right and the consciousness of patient-centered.

Many problems and challenges,which are closely related to the background of multiculture,exist in the current education of humanistic quality for medical students in China.Therefore,it is important to enhance the humanistic quality of medical students under the multi-cultural background.Following countermeasures can be taken to strengthen the humanistic quality of medical students,including establishing the curriculum for humanistic education,enriching humanistic knowledge of medical students,building dense on-campus cultural environment,transforming students′ recognition of humanistic education,and developing various social practices of humanistic quality.

Background: The purpose of this research was to assess the role of heparanase (HPSE)/syndecan1 (SDC1)erve growth factor (NGF) on cancer pain from melanoma. Methods: The influence of HPSE on the biological function of melanoma cells and cancer pain in a mouse model was evaluated. Immunohistochemical staining was used to analyze HPSE and SDC1. HPSE, NGF, and SDC1 were detected using western blot. Inflammatory factors were detected using ELISA assay. Results: HPSE promoted melanoma cell viability, proliferation, migration, invasion, and tumor growth, as well as cancer pain, while SST0001 treatment reversed the promoting effect of HPSE. HPSE up-regulated NGF, and NGF feedback promoted HPSE. High expression of NGF reversed the inhibitory effect of HPSE down-regulation on melanoma cell phenotype deterioration, including cell viability, proliferation, migration, and invasion. SST0001 down-regulated SDC1 expression. SDC1 reversed the inhibitory effect of SST0001 on cancer pain. Conclusions The results showed that HPSE promoted melanoma development and cancer pain by interacting with NGF/SDC1. It provides new insights to better understand the role of HPSE in melanoma and also provides a new direction for cancer pain treatment.