Objective To identify factors for blood disqualification,so as to take appropriate measures to prevent or reduce the blood disqualification.Methods According to the Operation Standards of Blood Station[No.448(2000)]published by the Ministry of Public Health,blood qualification and disqualification was judged.The blood samples were divided into three groups:group 1 collected from the mode of planning donation without reward;group 2 from the mode of voluntary blood donation without reward;and group 3 from the combination of the above.Results Totally 63 408 u were collected during the four years,of which 2 418 were disqualified and the disqualification rate was 3.81%.The disqualification rate of group 3(4.75%)was the highest,followed by that of group 2 (4.24%)and group 1(1.82%).There was significant difference among the samples collected from different months.And the descending order of blood type of disqualified blood was as follows:type O,A, B, and AB.The existence of anti-TP antibody and ALT elevation were the two main factors for blood disqualification,which disqualification rate was 1.73% and 0.93% respectively.Conclusion It suggests that propaganda of blood donation knowledge,selection of blood donors,ID and finger print identification for them,quality control of the blood station should be enhanced so as to prevent or reduce the blood disqualification.