Nipah virus (NiV) is a zoonotic paramyxovirus that has recently emerged as a crucial public health issue. It can elicit severe encephalitis and respiratory diseases in animals and humans, leading to fatal outcomes, exhibiting a wide range of host species tropism, and directly transmitting from animals to humans or through an intermediate host. Human-to-human transmission associated with recurrent NiV outbreaks is a potential global health threat. Currently, the lack of effective therapeutics or licensed vaccines for NiV necessitates the primary utilization of supportive care. In this review, we summarize current knowledge of the various aspects of the NiV, including therapeutics, vaccines, and its biological characteristics, epidemiology, pathogenesis, and clinical features. The objective is to provide valuable information from scientific and clinical research and facilitate the formulation of strategies for preventing and controlling the NiV.
Animals ; Humans ; Disease Outbreaks/prevention & control* ; Henipavirus Infections/virology* ; Nipah Virus/pathogenicity* ; Viral Vaccines ; Zoonoses/virology*

[Objective]To investigate the feasibility of the dermal pluripotent stem cells in the repairing of cartilage defects.It was aimed to provide experimental basis in view of cartilage defects of expanding the repair of cartilage defects seed cells selection. [Method]Neonatal cyanotic blue rabbits were used.Dermal tissue directly isolated through mechanical method and cells through enzymatic digestion were obtained.The growth characteristics of adherent adhesion of stem cells were used to obtain high cloned cells,which were subcultured.The cell concentration of 1?106/ml was cultured with polylactic acid scaffold for one weeks,and the obtained result was implanted into full-thickness articular cartilage defects of rabbits.Thirty cyanotic blue rabbit(60 joints)for about 3~5 months were randomly divided into three groups:dermal pluripotent stem cell / scaffold polylactic acid in group A,polylactic acid scaffold in group B,controls in group C.Twenty joints for each group.The rabbits were killed by air embolization at 12 weeks,restoration organization was extracted and stained by HE and toluidine blue.According to the repairing result of cartilage defect,gross and histologic scoring was made,and analyzed by statistics.The comparison of score difference between each groups was performed statistically.[Result]Gross and histological observation demonstrated that in group A organizations had smooth surface,appeared transparent,good integration with surrounding cartilage and subchondral bone.In group B there was a tiny transparent cartilage,and the fiber cartilage repair accounted for much proportion.The surface of group C showed some defects,mainly characterized by fibrous cartilage repair.After gross and histological observations statistics score analysis was performed.Results showed that group A is the most optimal(P