OBJECTIVE:To observe the stability of phacolin eye drops.METHODS:The content and the stability of phacolin eye drops were determined by ultraviolet spectrophotometry and the initial average rate method respectively.RESULTS:The activation energy for pyrolytic reaction of phcolin eye drops was25.681kcal/mol,the shelflife of phacolin eye drops at room temperature(25℃)and10℃were88and878days respectively.CONCLUSION:The determination of the stability of phacolin eye drops with initial average rate method is useful and simple.