Objective To investigate the effect of rosuvastain on the lung function and quality of life in patients with stable chronic obstructive pulmonary disease(COPD).Methods 88 patients with COPD were selected, they were divided into the research group and the control group by digital table method,each group had 44 cases. Traditional treatment was used to treat patients in the control group,the research group was treated with rosuvastain 20mg,1 time one day on the basis of the traditional treatment,all patients were treated for 6 months.Before treatment, 1 month after therapy and 6 months after therapy,the first second forced expiratory volume(FEV1 ),forced expiratory volume in first second(FEV1 ),forced vital capacity(FVC%)value and the patients'lung function were determined, the patients'quality of life was evaluated by the COPD Assessment Test (CAT).Results After1 and 6 months of therapy,the FEV1 ,FEV1/FVC of the two groups were higher than before treatment,and after 6 months of therapy,the FEV1,FEV1/FVC of the research group were (1.49 ±0.40)L,(59.35 ±5.51)% respectively,which were significantly higher than (1.28 ±0.31)L,(53.02 ±5.60)% of the control group(t=2.753,5.345,all P<0.05). After 1 and 6 months of therapy,the CAT scores of the two groups were lower than before treatment,and after 6 months of therapy,the CAT score of the research group was (17.27 ±3.32)points,which was significantly lower than (21.25 ± 4.51)points of the control group(t=-4.714,P<0.05).Conclusion Rosuvastain can improve lung function and quality of life in patients with COPD,the clinical curative effect is distinct,and it is worthy of popularization and application.

Although respiratory distress syndrome( RDS) ,one of the most common cause of respira-tory failure in the very or extremely preterm infant,has not been yet the major disorder of death with advances of respiratory support;In fact,RDS often complicated with BPD which developed with the maturation of de-pendence,the outcome of BPD and its development step into the focus of modern NICU. Powerful evidence-based consensus and suggestions have been stated in early respiratory support for very and extremely preterm infant:Early nasal CPAP( nCPAP) should be the best alternative to intubation for very or extremely preterm infant with high-risk of RDS and RDS; Early administration of Pulmonary surfactant ( PS ) with suitable methods( InSurE,Intubation Surfactant Extubation or LISA,Less invasive surfactant administration);Individ-ual threshould for nCPAP or other noninvasive ventilation failure should be established,but early PS adminis-tration and gentle ventilation will decrease the incidence of ventilator-induced injury on failuring noninvasive ventilation;Noninvasive ventilation with the use of caffeine will short the duration of ventilation and improve the success of weaning off. All the strategies in respiratory support to prevent BPD for very preterm infant still need more practice sustain improvement since multiple causes account for the development of BPD.

Objective:To develop an HPLC method for the simultaneous determination of flavonoids and phenolic acids in Herba Gnaphalium Affinis. Methods:The analysis was carried out on a Diamonsil C18 column (200 mm × 4. 6 mm, 5μm) with gradient elu-tion using methanol-0. 4% phosphoric acid as the mobile phase. The flow rate was 1. 0 ml·min-1 and the detection wavelength was 327 nm for flavonoids and 360nm for phenolic acids,the column temperature was 30℃, and the sample size was 10 μl. Results:The calibration curves were linear over the range of 0. 041-0. 821 μg for chlorogenic acidrutin, 0. 127-2. 549 μg for 3, 5-O-dicaffeoyl quin-ic acid, 0. 020-0. 411 μg for quercetin and 0. 040-0. 806μg for luteolin. The average recovery was 98. 31% ( RSD = 1. 19%), 97. 51%(RSD=1. 52%), 98. 29%(RSD=1. 22%) and 98. 73%(RSD=1. 47%), respectively. Conclusion:The described meth-od is simple and reproducible, which can be used for the quality control of Herba Gnaphalium Affinis.

OBJECTIVE:To study the features of ADR induced by anti-infective drugs and discuss the factors causing ADR.METHODS:A total of 142 ADR cases reported by our hospital in 2006 were analyzed statistically in respect of patients’ age and sex,drug kinds,route of administration and clinical manifestations etc.RESULTS:A total of 19 kinds of drugs were involved in the ADR,with cephalosporins took the lead,followed by quinolones,most of the drugs were given intravenously. Lesions of skin and the appendages were the chief manifestations of ADR.Of the total ADR cases,3 were serious.CONCLUSI-ON:ADR monitoring should be strengthened in using anti-infective drugs,especially for those hidden and chronic ADR.

OBJECTIVE:To establish the quality standard of Compound gaobo intranasal spray.METHODS: Rhizoma et Radix Ligustici,Mentha haplocalyx and Borneolum Syntheticum in the preparation were identified qualitatively by TLC,and the content of ferulic acid was determined by HPLC.RESULTS: Rhizoma et Radix Ligustici,Mentha haplocalyx and Borneolum Syntheticum were well-separated and distinctive in TLC.The linear range of ferulic acid was 0.292～0.876 ?g(r=0.999 9) and the average recovery was 97.97%(RSD=1.70%,n=6).CONCLUSION: The established standard is applicable for the quality control of Compound gaobo intranasal spray.

OBJECTIVE:To provide reference for clarifying the responsibility of hospital pharmacists to ensure the safety of intravenous infusion. METHODS: By combining personal experience,the author presented the ways for pharmacists to ensure safety of intravenous infusion such as by ensuring the rationality of prescriptions,guiding nurses to carry out medical order accurately and administer drugs correctly,guiding patients about drug use and offer guidance about the choice of infusion apparatus,etc. RESULTS & CONCLUSIONS: Pharmacists should apply the pharmaceutical knowledge gained to conduct an effective interference on the irrational use of intravenous drugs and cooperate with doctors and nurses to guarantee medication safety in intravenous infusion.

The STAT3 protein is a key transcription factor that delivers extracellular signals into nuclei in which it binds to a specific recognition element on DNA sequences and thus regulates the transcription of its target genes.STAT3 is almost expressed in all tissues and cells, therefore, it is extensively involved in both normal and aberrant cellular activities.For example, STAT3 plays an essential role in inflammatory reaction and tumorigenesis.STAT3 has been established as a therapeutic target of various cancers including multiple myeloma,a hematological malignancy from plasma cells.Some STAT3 inhibitors have been developed and extensively studied.In this article, we review the roles of STAT3 in multiple myeloma.The advances and strategies in the development of STAT3 inhibitors are also being discussed.

Objective To study the clinical curative effect and mechanism of Senggin Xinmaitong capsule in the treatment of non -proliferative diabetic retinopathy.Methods One hundred and twenty patients with non -prolif-erative diabetic retinopathy were randomly divided into the observation group and control group.The control group was given the standard treatment according to the clinical diagnosis and treatment guidelines for diabetic retinopathy in China in 2014.The observation group was treated with Senggin Xinmaitong capsule on the basis of treatment of the control group.Treatment time was 6 months.Before treatment and after treatment,ELISA method was used to detect serum transforming growth factor beta 1 (TGF - 1 ),interleukin -6 (IL -6)and vascular endothelial cell growth factor (VEGF)levels,and according to the performance of the vision and fundus,the clinical efficacy was observed and compared between the two groups.Results Comparison between before treatment and after treatment,the serum levels of TGF -1,IL -6 and VEGF were[(65.19 ±4.53)μg/L vs.(32.90 ±5.17)μg/L,t =3.905],[(45.18 ± 3.28)pg/mL vs.(24.87 ±7.09)pg/mL,t =3.275],[(175.43 ±21.59)μg/L vs.(109.98 ±10.21 )μg/L,t =3.316]respectively in the observation group,while the levels of TGF - 1,IL -6 and VEGF were [(64.97 ± 5.37)μg/L vs.(50.91 ±4.85)μg/L,t =2.761],[(47.09 ±3.16)pg/mL vs.(35.28 ±5.10)pg/mL,t =2.874], [(168.17 ±28.05)μg/L vs.(147.09 ±12.38)μg/L,t =2.548]respectively in the control group,after treatment, the serum levels of TGF -1,IL -6 and VEGF were decreased in the two groups compared with pre treatment(all P <0.05),and the improvement in the observation group was significantly better than the control group[t value(IL -6, TGF -β1,VEGF)=3.031,3.003,3.006,all P <0.05].The clinical efficacy of the observation group was better than the control group,the difference was statistically significant (90.00% vs.73.33%,χ2 =2.872,P <0.05 ). Conclusion The Senggin Xinmaitong capsule can significantly improve the clinical symptoms of patients with non -proliferative diabetic retinopathy,increase the visual acuity level and down -regulation of inflammatory reaction,inhi-bition the level of VEGF,thus to delay the progression of the disease.

There are more complicated pathological changes in the developing brain with invasive infection of central nervous system(CNS) which absolutely play predominant role in neurodevelopmental disability and mortality in spite of a lower prevalence during neonatal period.Bacterial meningitis demonstrated by cerebrospinal fluid(CSF) culture only remain difficult since poor positive findings,in the severe condition more complications could be often found such as vasculitis,ventriculitis,cerebritis and abscess.Cerebral abscess could be found independently without abnormal CSF examination;while the cerebritis is one of the primary pathological changes in viral invasive infection of CNS,Enterovirus/human parechovirus often involved not only grey matter,but also the periventricular and subcortical white matter that sound similar to the findings of periventricular leukomalacia on magnetic resonance imaging(MRI).Finding the complications of CNS infections early and accurately describe pathological changes by reasonable using MRI can enhance the therapy and predictive ability.

Regulatory T cells (Tregs) play important roles in immune homeostasis and tolerance.Recently, several characteristic studies on tissue-resident Tregs have been drawing wide attention.Some tissue-resident Tregs express some special molecules and are involved in the regulation of local tissue functions apart from immune regulation.This article focuses on the functions of some tissue-resident Tregs, such as fat-resident Tregs participating in the regulation of insulin resistance, muscle-resident Tregs in the regeneration and repair of damaged skeletal muscle, and thyroid-resident Tregs in the regulation of thyroid function, aiming to help medical graduates further understand the phenotypes and functions of tissue-resident Tregs.