Liver transplantation rapidly has become the best choice for pediatric patients with end-stage and metabolic liver disease, since the first liver transplantation succeeded in 1989. In pediatric liver transplantation, significantly improved short-term and long-term survival is attributed to advances in surgical techniques and reasonable immunosuppression regimens in the last 20 years. However, postoperative infections, which remain the most common complication following pediatric liver transplantation, severely affect posttransplantation morbidity and mortality. This paper summarizes the infections after liver transplantation in children and rational drug use.

Objective To investigate the clinical efficacy of trimetazidine combined with atorvastatin in the treatment of patients with coronary heart disease and its influence on serum lipid and hemorheology.Methods 140 cases with coronary heart disease were randomly divided into two groups.The control group was given trimetazidine on the basis of the conventional treatment,while the observation group was given atorvastatin on the basis of the control group.The clinical efficacy,changes of hemorheology and blood lipid were compared between the two groups.Results The effective rate of the observation group was 95.71％,which was significantly higher than 77.14％ of the control group (x2 =10.620,P ＜ 0.05).After treatment,TC,TG,LDL-C and HDL-C of the observation group were (2.54 ± 0.32) mmol/L,(1.41 ± 0.32) mmol/L,(1.53 ± 0.33) mmol/L and (0.73 ± 0.35) mmol/L,which were significantly lower than those of the control group (t =7.42,8.09,8.11,9.03,all P ＜ 0.05).After treatment,the nbh,nbl,np and HCT of the observation group were (5.11 ± 0.51) mPa/s,(8.03 ± 1.12) mPa/s,(1.02 ± 0.21) mPa/s and (40.34 ± 3.28) ％,which were significantly lower than those of the control group(t =8.33,9.14,8.08,9.44,all P ＜ 0.05).Conclusion Trimetazidine combined with atorvastatin in the treatment of coronary heart disease can significantly improve patients' lipid and hemorheology,and it can be promoted and applied in clinical practice.

Objective To compare the effects of two kinds of small incision operation in patients with diabetic cataract.Methods 100 patients with diabetic cataract were randomly divided into the two groups:the observation group(n=50,76 eyes) and the control group(n=50 cases,73 eyes).The observation group was operated through small incision non-phacoemulsification.The control group was treated with small incision phacoemulsification.The two groups of visual acuity,corneal endothelial cell density,corneal edema and postoperative astigmatism were compared. Results Two different eye surgery before the vision was no significant difference in the distribution segment(χ2 =0.297,P>0.05).Different postoperative visual acuity eye segment distribution after 3d were significantly different (χ2 =1.163,P>0.05).Different postoperative visual acuity eye segment distribution after 1m were significantly different(χ2 =0.928,P >0.05).The control group preoperative corneal endothelial cell density was (2 369 ± 261)cells/mm2,the observation group (2 403 ±277)cells/mm2.Preoperative corneal endothelial cell density was no significant difference between the two groups(t=0.467,P>0.05).Postoperative 3d and 1m,corneal endothelial cell density was (1 635 ±189)cells/mm2 and (1 706 ±196) cells/mm2 in the control group,(1 931 ±207) cells/mm2 and (1 982 ±203)a/mm2 in the observation group.The observation of corneal endothelial cell density was significantly higher(t=2.726,2.460,all P<0.05).The incidence of postoperative corneal edema were 35.6%,51.3%,and the observation group was significantly higher(χ2 =4.960,P<0.05).The incidence of postoperative astigmatism were 42.5%,26.3%,and the observation group was significantly lower than those of the control group(χ2 =5.210,P<0.05).Conclusion Two small incision surgery has advantages and disadvantages,and the effect is quite.

Objective:To study the treatment effects of 12 cases of Class II division 1 malocclusion using Bionator appliances. Methods:12 cases of Class II division 1 malocclusion were selected and treated with Bionator appliances. The changes of teeth, skeletal and facial appearance were analyzed by cephalometry before and after the treatment of Bionator appliances. Results:①Bionator appliances can hardly restrain the maxillary growth. ②Bionator appliances can promote the mandibular ramus and body growth and improve the soft tissue profile. ③Bionator appliances can reduce the labial inclination of upper incisors of Class II division 1 malocclusion and can increase the height of dental alveolar of upper and lower jaw. Conclusion:In Class II division 1 malocclusion treatment, Bionator appliances can obtain satisfactory effects.

The isolation purification, iodination and identification of a-Bungarotoxin(a-BTX)were recorded.Purified a-BTX was prepared from the venom of Hunan Bu-ngarus multicinctus (Blyth) by CM-Sephadex C~50 ionexchange chromatography and Sephadex G~25 chromatography.The homogeneous a-BTX was obtained by rechromatography of purified ct-BTX (fraction 3) on a CM-Cellulose CM-32, and was labelled with 1251 by chloramine-T method.The 1251-?-BTX was then separated from Na125I and purified by Sephadex G-25 column.The results yield a specific activity of 90~100 Ci/mM.40~50% labelling.40~60% recovery of protein and less than 3 % contamination with free iodine in 125I-?-BTX.The purified a-BTX was identified by determining its N-terminal amino acid, amino acid composition, isoelectric and polyacrylamide gel electrophoresis.Biological activity of the ?-BTX was determined by its toxicity to mice, its neuromuscular blocking action and binding to acetylcholine receptors at the motor entplate of the rat diaphragm.

OBJECTIVE:To establish a method for the content determination of tetracaine hydrochloride and ethyl hy-droxybenzoate in tetracaine hydrochloride mucilage by RP-HPLC.METHODS:C 8 was the chromatographic column,the mobile phase was methanol-absolute ethanol-water-triethylamine(70∶15∶15∶0.05),the detection wavelength was at280nm.RESULTS:The linear ranges of tetracaine hydrochloride and ethyl hydroxybenzoate were10～50?g/ml(r=0.9997)and2～10?g/ml(r=0.9999)respectively;the average recovery rate were100.82%and100.16%respectively.CONCLUSIONS:The method was simple,rapid and accurate,which can be used for the quality control of tetracaine hydrochloride mucilage.

OBJECTIVE:To establish a RP-HPLC method for simultaneous determination of furacillin and sodium ben-zoate in furacillin solution.METHODS:Shim-pack C 8 was used as the chromatographic column;the mobile phase was methanol-water(35∶65),the detecting wavelength was240nm.RESULTS:The linear ranges of furacillin and sodium ben-zoate were1.0～40.0?g/ml(r=0.9998)and5.0～200.0?g/ml(r=0.9996)respectively,the average recovery was100.1%(RSD=1.52%)and99.7%(RSD=1.57%)respectively.CONCLUSION:The method is simple,rapid and accurate and it can be used for the quality control of furacillin solution.

OBJECTIVE:To probe into the evaluation method on technological capability of pharmaceutical enterprises.METHODS:The connotation of pharmaceutical enterprises'technological capability was expounded;the characteristics of each evaluation index,i.e.output index and input index of technological capability of pharmaceutical enterprises were ana?lyzed.RESULTS:Detailed and complete information on the evaluation of pharmaceutical enterprises'technological innovation capability was unavailable from the output index and input index only.CONCLUSION:The evaluation on pharmaceutical enterprises'technological innovation capability should include more comprehensive,more dynamic and more integral evaluation indexes.

OBJECTIVE:To cultiveate and development of Research &Development(R &D)abilities for new drugs for Chinese pharmaceutical enterprises.METHODS:The experiences on new drugs' R&D of some Indian pharmaceutical enterprises were analyzed.RESULTS &CONCLUSION:To improve R &D abilities for new drugs,Chinese pharmaceutical enterprise should try to explore effective ways and measures by not only emphasizing the strategic value of R&D for new drugs,but also strengthening the cooperation with outside,attracting the overseas talents,cultivating the integrative capa-bility,etc.

In This article we report 80 cases of psoriasis confined to the leg hand or foot of the patients. The diagnoses all been confirmed by definite pathological examinations of the cutaneous tissue. As this disease appears on peculiar sections of the body is affected by many physio-chemical factors, the form of cutaneous damage produces different changes of various degrees, so the typical damage is not shown usually. Therefore misdiagnosis leads us to consider it to be case of neurodermatitis, eczema, chronic dermatitis and tinea. The author has made analysis on causes of misdiagnosis and suggested methods to discern proper diagnosis of this disease.