1.The correlation of serum SOD and CD4+CD25+regulatory T cell in the mechanism of severe sepsis
Junling LI ; Hancong WU ; Tao DENG ; Yixian LIANG ; Chunming LIN ; Wenlong DENG ; Jie ZHANG ; Manni QIN
The Journal of Practical Medicine 2017;33(15):2536-2538
Objective To evaluate the condition of oxidative stress and immunosuppression in early stage of severe sepsis,and investigate the correlation between them. Methods A prospective random control study in-cluded patients group(n=51)and control group(n=31). The concentration of serum superoxide dismutase was measured by enzyme linked immunosorbent assay(ELISA),CD4+CD25+Treg% was measured by flow cytometry , respectively. The difference between two groups was compared and the correlation between parameters in patients group was evaluated. Results The concentration of serum SOD was lower than control group (P < 0.01). CD4+CD25+Treg% significantly high,compared to the control group(P < 0.01). There was no strong correlation be-tween parameters in patients group. Conclusion Oxidative stress and immunosuppression are exist in the early stage of severe sepsis.
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