Hypoxemia is a common pathological state characterized by low oxygen saturation in the blood. This condition compromises mucosal barrier integrity particularly in the gut and oral cavity. However, the mechanisms underlying this association remain unclear. This study used periodontitis as a model to investigate the role of platelet activation in oral mucosal immunopathology under hypoxic conditions. Hypoxia upregulated methyltransferase-like protein 4 (METTL4) expression in platelets, resulting in N⁶-methyladenine modification of mitochondrial DNA (mtDNA). This modification impaired mitochondrial transcriptional factor A-dependent cytosolic mtDNA degradation, leading to cytosolic mtDNA accumulation. Excess cytosolic mt-DNA aberrantly activated the cGAS-STING pathway in platelets. This resulted in excessive platelet activation and neutrophil extracellular trap formation that ultimately exacerbated periodontitis. Targeting platelet METTL4 and its downstream pathways offers a potential strategy for managing oral mucosa immunopathology. Further research is needed to examine its broader implications for mucosal inflammation under hypoxic conditions.
DNA, Mitochondrial/metabolism* ; Mouth Mucosa/pathology* ; Hypoxia/immunology* ; Methyltransferases/metabolism* ; Blood Platelets/metabolism* ; Animals ; Periodontitis/immunology* ; Humans ; Platelet Activation ; Mice

In educating postgraduate students in aerospace medicine in our country, there are some deficiencies such as the course content lacking forward looking and systematicness, and students' mastery of technology or skills lacking professional characteristics, innovation and divergent thinking. Based on the original foundations, the School of Aerospace Medicine, Fourth Military Medical University, has been con-structing and improving the course system by modifying the course contents, reforming the practical teach-ings, expanding the academic communications, and managing the processes. Finally, they have achieved certain results.

Objective To explore the community nursing talents' occupation quality demand in the purpose of periodically providing reference for higher medical institutions' nursing education and for job training of community nurses.Methods The community nurses in the 15 qualified communities' medical organizations in the city of Zunyi were investigated through self-designed questionnaires,analyzing the basic qualifications,humanistic knowledge,professional knowledge and profession ability demand that community nursing talents were supposed to possess.Results The demand of high occupation responsibility and strict working style amounted to a relatively large proportion among the 11 basic qualifications.Demand of nursing etiquette and community nursing management occupied a relatively large proportion among the 9aspects of community nurses' humanistic knowledge demands.Demand of the often used community nursing technical operation and common drugs' clinical application knowledge took up a relatively large proportion among the 16 community nurses' professional knowledge demands.Demand of interpersonal and communication skills and self protection ability held a relatively large proportion among the 14 community nursing talents' occupation ability demands.Conclusions Oriented to the demand of the community nursing talents' occupation quality demands,relevant higher medical institutions or colleges concerned should strengthen the basic quality,optimize the curriculum structure and improve occupation ability in the purpose of culturing the community nursing talents who are able to adapt to the demand of community health service and have higher overall qualities as well.