1.Assessing neuro-psychological status of drivers involved in the traffic accidents
Ulziibayar D ; Mandakh T ; Bujin TS ; Gantsetseg T ; Nomindalai B
Mongolian Medical Sciences 2013;163(1):158-163
Psycho-neurological syndrome which is driver’s health status plays a crucial role in ensuring road traffic safety.GoalThe study aims to determine factors leading to traffic accidents by assessing psycho-neurological status of drivers who caused road traffic accidents.MethodsIt is a double-randomized and cross-sectional study. Drivers caused the traffic accidents in the territory of Bayanzurkh District of Ulaanbaatar city between September 2011 and May 2012 were involved.Following investigations were done:• Thorough neurological examination using a prepared clinical pathway;• EEG test;• Assessment of attention, memory, intellectual speed and anxiety of drivers using Lusher test and computer based test.SPSS 18 was applied in data analysis and chi square test was applied in differentiation the proportions.ResultsThe male-female ratio among 394 drivers was 61.9% and 38.1% respectively. 322 drivers (89.04%) had symptoms of episodic headache, dizziness, blurred vision and unsteadiness. 60 drivers (15.2%) had nystagmus which is the main symptom of vertigo (p<0.001). 159 (40.9%) drivers experienced an insomnia. Epileptic and nonepileptic seizure was observed in 155 cases. Out of 394 drivers 243 (61.6%) had symptoms of anxiety. It was observed that 64.6% had low level of anxiety, 27.9% had medium, 7% had high level and 0.4% had severe anxiety. According to the Shultz table, we found that 46.4% of drivers were disintegrated attention and 12.4% (49) were with slow intellectual speed. The hypomnesia was 27.4% (108).Conclusions:1. According to our study, anxiety is dominated among the drivers and attention is disintegrated and slow.2. EEG results (abnormal II and III) proved that drivers who have epileptic and nonepileptic seizures are involved in the traffic accidents.3. Recurrent neurological conditions like headache, dizziness, insomnia, blurred vision and unsteadiness are preconditions for attention dispel, slowing of attention distribution and anxiety of drivers who caused traffic accidents and those recurrent neurological conditions are prevalent among drivers.
2.Effect Of Some Traditional Drug And External Therapies On Changes Of Tnf Levels
Li Mandakh ; Ambaga M ; Tserendagva D ; Oldokh S
Journal of Oriental Medicine 2012;3(2):24-24
In this study, the effects of traditional drugs such as Zachun-13 and
Sampilnorov on serum levels of tumor necrosis factor (TNF) in mice
model of arthritis induced by formalin were examined. Moreover, the
effect of traditional external therapies including acupuncture,
cauterization, pricking-cupping and massage on serum TNF levels in
patients with spinal disk herniation and long-term back muscle
injury.
The study was done at the Research Center of Monos Medical
University. Arthritis was induced by formalin (0.5 g/kg) injection into
the phalangeal joints of mice. Sampilnorov and Zachun-13 were
administered daily through oral tube at concentration of 42.5 mg/kg
and 14 mg/kg respectively. Serum levels of TNF were determined 1,
3 and 7 days after initiating the treatment. Acupuncture,
cauterization, pricking-cupping and massage were applied to
patients once a day for 10 days.
After 1 day of treatment, serum levels of TNF was increased 3.09
fold by formalin administration compare to control. This increase
was reduced by Sampilnorov and Zachun-13 1.19 and 1.8 fold
respectively. Serum levels of TNF were increased 3.0 fold in mice
after 3 days of formalin administration. Sampilnorov and Zachun-13
reduced these increases 1.17 and 1.93 fold respectively.
Serum levels of TNF increased 15.2 fold in patients with spinal disk
herniation and long-term back muscle injury compare to normal
range of TNF level. Acupuncture, cauterization, pricking-cupping
and massage reduced increased serum levels of TNF in patients 1.3
fold.
These results indicate that traditional drugs Zachun-13 and
Sampilnorov and traditional external therapies including
acupuncture, cauterization, pricking-cupping and massage can be
effective for treatment of joint conditions by inhibiting TNF
production.
3.Overview of study traditional Mongolian prescription Sugmel-7
Tongshan ; Mandakh ; Tsend-Ayush D ; Enkhtsetseg J ; Wanghuan
Mongolian Pharmacy and Pharmacology 2019;14(1):19-23
Abstract
This article included overview of study of Traditional Mongolian prescription Sugmel-7.
The uses of traditional medicine Sugmel-7 collected by Classic books of Mongolian traditional
medicine, Prescription of Mongolian traditional medicine textbooks. Overview modern medicine
study of Sugmel-7 searched by online Chinese fund of knowledge, research materials of Inner
Mongolian University of nationalities. It would be provided traditional prescription Sugmel-7 future
study clarification.
4.Changes in rat behavior, lung, and hippocampal effects due to vaping exposure
Oyungerel S ; Tumenbayar B ; Javzandulam B ; Chimegsaikhan S ; Khulan B ; Altantsetseg B ; Mandakh-erdene B ; Munkhsoyol E
Mongolian Journal of Health Sciences 2025;87(3):141-146
Background:
Nicotine-containing vaporized liquids—composed of
propylene glycol, glycerin, water, flavorings, and the thickening agent
vitamin E acetate—have been implicated in the development of EVALI.
Under conditions of low liquid levels and overheating, these substances
release toxic carbonyl compounds (e.g., formaldehyde, acetaldehyde,
acrolein). In a 2019 national survey, 3.5% of adolescents aged 13–15
reported cigarette use, and 10% used e-cigarettes.
Aim:
To study the changes in the behavior, lung, and hippocampal
structures of rats due to the effects of electronic cigarettes and their
vapor.
Materials and Methods:
In this study, nineteen 14-day-old SHR rats
were exposed to 1 g/mg/day of nicotine and dry hit vapor (control, nicotine
and dry hit groups) for four weeks. Behavioral assessments (Open
Field Test, Elevated Plus Maze, Conditioned Place Preference), bronchoalveolar
lavage (BAL), and histological analysis of lung and hippocampal
tissue were conducted.
Results:
The dry hit vapor group showed significantly reduced body
weight (p=0.034), increased anxiety (p=0.006, p=0.025), and avoidance
of the smoky chamber. BAL revealed elevated total cells, neutrophils,
and macrophages (p=0.01, p=0.04) in both nicotine and dry hit groups.
Lung tissue exhibited alveolar septal thickening, inflammation, and emphysema-
like changes. Extensive neuronal death was observed in the
hippocampus.
Conclusion
Anxiety-like behavior was observed in both the burn and
control groups. Analysis of BAL in the dry hit group revealed inflammation
predominantly characterized by macrophage infiltration. Histological
examination of lung tissue from both experimental groups
demonstrated a reduction in the number of alveoli, accompanied by
acute inflammation and thickening of the interalveolar septa. In the hippocampal
region, neuronal loss and a reduction in neuronal density
were also observed.