Virilization is the masculinization and enhancement of male secondary sexual characteristics in females. The etiology may be of adrenal or ovarian in origin. This case report shows a 46 year old woman who presented with defeminizing and virilizing symptoms. Further laboratory investigations revealed increased serum androgen levels and normal CT scan of the adrenals and kidneys. An ovarian mass was confirmed by transrectal ultrasonography. Following a total abdominal hysterectomy and bilateral salpingooophorectomy, histopathological and immunohistochemistry studies on the left ovarian mass confirmed an androgen-secreting, steroid-cell tumor, not otherwise specified (NOS). Serum testosterone values abruptly declined to normal levels within 1 month post-surgery. This paper likewise discusses an extensive review of literature regarding this rare ovarian tumor.

Human ; Female ; Middle Aged ; Virilism

Low malignant potential serous tumors are the most common subtypes of non-benign serous tumors in the young, usually confined to one or both ovaries. To preserve ovarian function and fertility conservative management can be performed. Although recurrence is higher than that after a completion surgery, the rate of recurrences continues to be debated. Most recurrent diseases are of the same histopathology as the initial tumor and adequate excision of the recurrent tumor can be done.

A 31-year old, primigravid underwent bilateral oophorocystectomy for serous borderline ovarian tumor stage IB. After 3 years she had tumor recurrence and another fertility-sparing surgery consisting of left salpingooophorectomy and contralateral cystectomy was done. Histopathology was a recurrent borderline ovarian tumor. Two years later, she had a spontaneous pregnancy and delivered to a live term baby. This is a reported case of a successful pregnancy after two fertility-sparing surgeries for borderline ovarian tumor.

Human ; Female ; Adult ; Pregnancy ; Cystectomy ; Conservative Treatment ; Ovarian Neoplasms ; Fertility ; Ovariectomy ; Neoplasms, Glandular And Epithelial