Objective To study the expression of CD44v6 and CD44s in bladder transitional cell carcinomas. Methods: The immunohistochemical staining of monoclonsl antibodies CD44v6 and CD44s were operated in 79 bladder transitional cell carinomas. Results (1) A strong expression of CD44v6 and CD44s were observed in atypical proliferation cells of bladder caricnoma in situ. (2) CD44v6 and CD44s expressed in recurrent I or Ⅱ grade transitional cell carcinomas were 90%(18/20) and 40%(8/20). (3) The positive expression rates of CD44v6 and CD44s were 43. 1%(31/72) and 13. 9%(10/72)in invasive transitional cell carcinomas; moreover, the expression of CD44v6 reduced with the poor differentiation and the deeply invasive growth of transitional eell carcinomas. Conclusion The investigation results suggested that CD44v6 played a role in the formation and recurrence of the bladder transitional cell carcinomas, but the reduced expression of CD44v6 probably related with the poor differentiation and invasive growth of the bladder transitional cell carcinomas.

Gastroesophageal reflux disease(GERD)is a commonly seen digestive disease. So far,there is no golden standard for the diagnosis of GERD. The main diagnosis methods used in clinical practice include gastroscopy,24 h esophageal pH monitoring and proton pump inhibitor test,however,these methods are either invasive or complex in procedure and with low diagnostic accuracy rate. Gastroesophageal reflux disease questionnaire(GerdQ)possesses multiple advantages such as simple,non-invasive and easily acceptable. This article reviewed the use of GerdQ in diagnosis of GERD.

Pruritus is one of the common clinical manifestations of cholestatic liver diseases such as primary biliary cirrhosis,primary scle-rosing cholangitis,and intrahepatic cholestasis of pregnancy.Potential incentives of itching include bile salts,histamine,progesterone me-tabolites,endogenous opioid substances,and lysophosphatidic acid,according to previous studies.However,the exact pathogenesis of chol-estatic pruritus remains unclear,and the current treatment can only alleviate the symptoms in some of the patients.Novel methods for treating pruritus have been proposed and/or are being studied.The recent experimental and clinical studies on the pathogenesis and treatment of pru-ritus in cholestatic hepatitis are reviewed,in order to improve the understanding and management of cholestatic pruritus.

Respirator breathing resistance impacts performance of wearers during constant work load. However, it is less clear as to how breathing resistance affects the tolerant capacity of users during graded work load. The present study investigated the tolerant capacity of 8 individuals during incremental work load. The 8 subjects were required to wear two matched respirators (respirators I and II which were designed to have different breathing resistances and the same dead space) respectively on separate days and then work to end points. Minute ventilation (V(E)), breathing frequency (BF), oxygen consumption (VO(2)) and heart rate (HR) were recorded during exercise, while tolerant time, response time and breathing discomfort were measured at the end of each test trial. The test variables were compared between the two respirators by using matched-pairs t-test. The results showed that the tolerant time was significantly reduced for the respirator I with higher level of breathing resistance when compared with its counterpart with lower breathing resistance (respirator II) (P<0.05). The same changes occurred for response time. Results also showed a significant increase in V(E) and BF for respirator I wearers when the work load was above 125 W. The O(2) consumption was similar under the two breathing resistance conditions. These findings suggested that the respiratory resistance caused by self-contained breathing apparatus (SCBA) has an impact on the tolerant capacity of users.

Ankle Injuries ; surgery ; Evidence-Based Medicine ; methods ; Foot Injuries ; surgery ; Humans

Objective To study the possibility of ultr asonic examination in evaluation of cleft palate repair. Methods The length, open-close movement of soft palate and velopharyngeal insufficiency were observed by ultrasonography in submaxillary region pre-operation and post-operation in 7 patients. Results After operation- the length of soft palate was longer than that before operation, the mean extended length was 13.7- mm; the movement of soft palate was increased; the velopharyngeal insufficiency was improved. Conclusions The observation of soft palate structure pre-operation and post-operation by ultrasonic examination is an objective index for evaluating the cleft palate repair.

There were few reports on minor injuries such as strains of hand, wrist and elbow, but there was no report on the supracondylar fracture of the femur in Bowler. The fracture is induced if the stance motion is unbalanced during the body weight shift from the throw in bowling.
Body Weight ; Elbow ; Femur ; Hand ; Wrist

The author reviewed 67 cases having medial instability of the knee joint from 1971 to 1980 who were treated by surgery at the Department of Orthopaedic Surgery at Ewha Womans University Hospital. The author reviewed 67 cases which showed medial instability from 1971 to 1980 who had been treated by surgery in the Department of Orthopaedic Surgery at Ewha Womans University Hospital and summarized as follows. 1. The majority of the medial instability was due to rupture of medial collateral ligament with capsular ligament (43.3%), and the rest were due to rupture of tibial collateral ligament only (35.8%). 2. The medial instability also produced by rupture of the other structures of the medial side of the knee joint without tibial collateral ligament rupture. 3. The stress radiogram was important guide line for the diagnosis of the injury of the medial structures of the knee joint. 4. The degree of medial joint space opening was increased with the number of structures injured.
Collateral Ligaments ; Diagnosis ; Female ; Humans ; Joints ; Knee Joint ; Knee ; Ligaments ; Medial Collateral Ligament, Knee ; Rupture

Lumbar discography was described as the clinical diagnostic method by Lindblom in 1948, but its clinical value is still controversial. There are many false positive on lumbar discography. As CT scans are new widely available, axial discography only deserve to evaluate accureately. In 41 patients of lower back apin, radiating pain & claudication that was not improved with conservative treatment for 2 weeks, plain and axial discography were performed. The results were as follows :l. Among the 41 patients, herniated lumbar disc swere 19 cases, lumbar syndromes were 8 cases, spondylolisthesis were 8 cases and spinal stenosis were 6 cases. 2. Among the 95 level of discography, the level of L4-5 & L5-Sl were 81%. 3. The incidence of pathologic discs classified by Quinnell classification and Dallas discography description at plain axial discography were 65%, 74%, respectively. 4. Among the 19 cases of operated herniated lumbar discs, false negative and false positive plain discagraphy were 21%, 11%, respectively. And false negative axial discography is 5.3%. 5. There was a significant relationship between pain on provocation test and degeneration of discs. 6. We can confirmed the pathologic discs prior to operation.
Back Pain ; Classification ; Humans ; Incidence ; Methods ; Spinal Stenosis ; Spondylolisthesis ; Tomography, X-Ray Computed

A comprehensive knowledge of spinal biomechanics is of importance for the understanding of all aspect of spinal kinematics, clinical analysis and management of spinal problems. The spine is a biomechanical structure. The spine is a composit of the motion segments including sophisticated ligaments and reinforced muscles on the back, abdomen and rib cage. With an integrity of the biomechanical structure of spine, it has fundamental biomechanical functions such as allowing the physiologic motion smoothly between the head & pelvis, resist the destructive motions by stiffening the spine, transfer the weight evenly and protect the delicate vulnerable spinal cord. The data of the biomechanical aspects enable to know the characteristics of spine, to analysis the clinical situations, and to manage the spinal problems in ideal manner so as to contribute spine in healthy.
Abdomen ; Biomechanical Phenomena ; Head ; Ligaments ; Muscles ; Pelvis ; Ribs ; Spinal Cord ; Spine