Objectives To understand the control and prevention status of water-borne endemic fluorosis in Jiangxi Province, in order to provide a scientific basis for evaluate and perfect the strategies in control and prevention of the disease. Methods According to monitoring project of national water-borne endemic fluorosis, three villages were chosen to investigate the status and the fluoride content of fluorosis villages with water-improving and defluoridation projects in Yushui district and Ningdu county of Jiangxi Province. Investigation consisted of the status of dental fluorosis of children aged from 8 to 12 years and adult skeletal fluorosis, as well as fluoride content of drinking water and urinary fluorine. The standard detection methods of domestic drinking water was used for water fluoride content detection, fluoride selective electrode was chosen for urinary fluorine detection, Dean detection method was used to determine dental fluorosis, and diagnostic criteria of endemic skeletal fluorosis was chosen for diagnose of skeletal fluorosis. Results In fluorosis villages with water-improving and defluoridation projects which operated normally, the fluoride content of drinking water was lower than 1.00 mg/L. In fluorosis villages with water-improving and defluoridation projects which never operated normally, the average fluoride content of drinking water was 1.76 mg/L. The detection rate of dental fluorosis of children aged 8-12 years was 12.50%(22/176). A total of 294 adults were examined by X-ray, 3 adults were diagnosed as skeletal fluorosis, and the detection rate was 1.02%. A total of 294 adult urine samples were tested. The urinary fluoride content varied from 0.28 to 7.74 mg/L, and the geometric mean was 1.10 mg/L. Conclusions The illness condition of water-borne endemic fluorosis has been under control effectively. The maintenance of water-improving and defluoridation projects and surveillance were main tasks in control and prevention of the disease in the future.

Pruritus is one of the common clinical manifestations of cholestatic liver diseases such as primary biliary cirrhosis,primary scle-rosing cholangitis,and intrahepatic cholestasis of pregnancy.Potential incentives of itching include bile salts,histamine,progesterone me-tabolites,endogenous opioid substances,and lysophosphatidic acid,according to previous studies.However,the exact pathogenesis of chol-estatic pruritus remains unclear,and the current treatment can only alleviate the symptoms in some of the patients.Novel methods for treating pruritus have been proposed and/or are being studied.The recent experimental and clinical studies on the pathogenesis and treatment of pru-ritus in cholestatic hepatitis are reviewed,in order to improve the understanding and management of cholestatic pruritus.

This article looked at the conflicts in depth between the “moral majority” and vulnerable to HIV homosexu-al of “minority”.Both group of the moral and status of social were discussed , and then put forward social justice and in-clusive moral of “moral majority” and“minority”, and take the analysis from the perspective of the “moral majority” and“minority” for the Ethics .

Iontophoresis possesses the unique superiority as an effective way for promoting the permeability in a therapy system which gives medicine through human' skin directly.It has been developing very quickly in recent years.The application of DC,pulse DC and the electroporation causes the flux greatly enhanced,especially the application of electroporation which can fast reduced the skin resistance and enhance the flux for its reversible function to the skin.What's more,there has been an improved way for iontophoresis now,which uses the AC with an offset of DC.This method can stabilize the skin resistance so as to stabilize the human epidermis membrane parameters,including the pore area,the pore distribution,the pore surface charge density,thus keeping the flux constant.

Objective:To explore risk factors for no‐reflow after emergency coronary intervention in aged patients with a‐cute ST elevation myocardial infarction (STEMI) . Methods:According to presence of no -reflow (≤TIMI grade Ⅲwas considered as no-reflow) after operation or not ,a total of 700 aged STEMI patients hospitalized in our hospital during 2010-2013 were divided into no-reflow group (n=190 ,27. 14% ) and reflow group (n=510 ,72. 86% ) . Clinical data , PCI and coronary angiography data were collected ,compared and analyzed between two groups . Results:Compared with reflow group ,there were significant rise in percentages of patients with TIMI grade 0-1 (61.17% vs. 82.11% ) ,coro‐nary collateral blood flow grade 0 (64.12% vs. 74.21% ) ,5 thrombus scores before PCI (58.83% vs. 80.00% );signifi‐cant reduction in systolic blood pressure (SBP) at hospitalization [ (111.2 ± 24.6) mmHg vs. (101.7 ± 25.9) mmHg] in no-reflow group , P<0. 01 all. Multi-factor Logistic regression analysis indicated that SBP<101 mmHg at hospitaliza‐tion ,collateral blood flow grade 0 before PCI and 5 thrombus scores before PCI were risk factors for no‐reflow after emer‐gency PCI (OR=1.006~4.398 , P<0.05 or <0.01) .Conclusion:In aged acute STEMI patients ,those with risk factors for no-reflow after emergency PCI should take corresponding preventive and therapeutic measures in order to improve their prognosis .

[Objective]To compare the reliability and value of clinical signs,MRI imaging and arthroscopy in management of meniscal tears in order to increase the diagnostic rate.[Method]A retrospective study was done on 176 cases undergoing MRI examination and arthroscopic treatment,and being diagnosed as meniscal injuries in knee joint by any one of the three clinical,MRI or arthroscopic examinations.Using arthroscopic diagnosis as the standard,the sensitivity,specificity.and overall accuracy of clinical diagnosis and MRI were then calculated respectively.Significant differences between arthroscopic diagnosis and clinical diagnosis or MRI diagnosis were analyzed using statistical method of Chi-square test.[Result]The sensitivity,specificity and accuracy of clinical diagnosis were 79.3%,26.3% and 73.8% respectively.There was statistically significant difference between arthroscopic diagnosis and clinical diagnosis.The sensitivity,specificity and accuracy of MRI diagnosis were 94.1%,92.9% and 93.4% respectively.The difference between arthroscopic diagnosis and MRI diagnosis had no statistically significance and can be used as an important examination before knee arthroscopy.[Conclusion]MRI is a reliable,noninvasive diagnostic tool for meniscal tears and can be used as an important examination before knee arthros copy with MRI examination combining with the clinical signs,diagnotic rate of meniscal tears can be increased.Unnecessary arthroscopic therapy could be avoided.

Objective:To analyze the situation of immunosuppressants utilization of renal transplantation inpa- tients in our hospital.Method:The records and relevant data of 98 case of renal transplant inpatients during 2005 were col- lected,and analyzed according to drug cost and defined daily dose(DDDs)ranking.Result:The average age was(42.50?10.56)a,the average drug cost was(18745.36?7603.86)yuan,the average inmunosuppressant cost was 13456.58 yuan,and all the drug utilization indicators(DUI)were≤1.Conclusion:The analysis shows that the inmunosuppressant utilization rate was high and the inmunosuppressant utilization by renal transplant inpatients was basically rational.

OBJECTIVE: To discuss the working pattern and key points for pharmacists to carry out pharmaceutical care.METHODS: The working contents and working pattern of pharmacists were summarized by reviewing the experience of pharmacists in carrying out pharmaceutical care in certain departments in our hospital. RESULTS & CONCLUSION: To carry out clinical pharmaceutical care service,clinical pharmacists should actively participating in clinical work by giving monitoring on prescriptions,drug interaction,ADR and nutritional support,and communication with patients etc.

No abstract available.

No abstract available.
Arthritis* ; Knee*