Introduction: In light of the importance of the nurses’ performance in health services, this study was established to examine the relationship of job performance with organizational commitment components and job satisfaction among nurses. It is also, to examine the mediating effect of job satisfaction in the relationship between organizational commitment components and job performance among nurses. Methods: This was a cross-sectional study conducted among nurses at Hospital Universiti Sains Malaysia. A sample size of 192 staff was selected using stratified and systematic random sampling methods. The study data were collected using a questionnaire consists of three scales: the organizational commitment scale of Allen and Meyer, the job satisfaction scale of Van Wood, and the task performance scale of Williams and Anderson. Besides, respondents were asked about their demographic profiles. The response rate was 92% (n= 176). Regression analysis according to Baron and Kenny technique and Pearson correlation were conducted to get the study results. Results: The study results showed that all organizational commitment components positively and significantly correlated with job satisfaction and job performance. Further, there is a positive relationship was found between job satisfaction and job performance. Moreover, findings of regression analysis showed that job satisfaction partially mediates the relationship between all organizational commitment components and job performance. Conclusion: Improving organizational commitment and job satisfaction among nurses could increase their performance. Nurses’ managers should create suitable approaches and strategies to promote the organizational commitment and job satisfaction of nurses to the highest level, which in turn enhancing their job performance and the quality of care.