1.Heterogeneous t(4;11) fusion transcripts in two infants with acute lymphoblastic leukemia.
Harvindar Kaur Gill ; Sew Keoh Ten ; Jasbir Singh Dhaliwal ; Sarah Moore ; Roshida Hassan ; Faraiza Abdul Karim ; Zubaidah Zakaria ; Shahnaz Murad ; Mahfuzah Mohamed ; Hishamshah Mohamad Ibrahim ; Eni Juraida Abdul Rahman
The Malaysian journal of pathology 2004;26(2):105-10
An RT-PCR assay detected the t(4;11) translocation in two infants with acute lymphoblastic leukemia (ALL). Case P76 was a 10-month-old, female infant, who presented with a WBC of 137.4 x 10(9)/l and a pre-pre-B ALL immunophenotype. Case P120 was a 6-month-old female infant, with a WBC > 615 x 10(9)/l and a pre-pre-B ALL immunophenotype. RT-PCR of cDNA from both these cases generated a 656 bp and a 542 bp respectively, which sequencing confirmed as t(4;11) fusion transcripts. The primers and conditions selected for this assay are compatible with a one-step multiplex PCR for the main translocations in childhood ALL.
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Leukemia, Lymphocytic, Acute
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Reverse Transcriptase Polymerase Chain Reaction
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Result Analysis
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