OBJECTIVETo investigate the clinical features and plasmapheresis treatment outcome of hyperlipidemic acute pancreatitis among Uyghur population.

METHODSThe clinical data of 41 cases (treatment group) diagnosed with acute hyperlipidemic pancreatitis and treated with plasmapheresis from August 2007 to August 2012 was studied, and treatment outcomes were statistically analyzed. Fifty patients during the same period who received medical treatment without plasmapheresis (control group) were collected, and were compared to the treatment group. Clinical data of 72 Han Chinese patients with hyperlipidemic acute pancreatitis from the same study period were compared to 91 Uyghur patients mentioned above. The data were analyzed by t-test or χ2 test.

RESULTSTreatment group and control group were comparable in terms of gender, age, APACHE II score at admission, BMI, and blood lipid levels. Thirty-two patients out of 41 in the treatment group were improved after routine medical treatment and plasmapheresis, but 9 died. In the control group, 28 out of 50 cases were improved, 22 died. The mortality of the treatment group was significantly lower than that of the control group(χ2 = 10. 824, P = 0. 001). Time of hospital stay in treatment group was (17 ± 16) days, and significantly shorter than that of control group ((28 ± 20) days) (t= 2. 851, P = 0. 005). Before plasmapheresis in the treatment group, serum triglyceride and total cholesterol levels were (58 ± 39) mmol/L and (24 ± 8) mmol/L, after plasmapheresis, these values dropped significantly to (10 ± 10) mmol/L and (6 ± 5) mmol/L. APACHE II score of those died were 18 ± 2, and significantly higher than those who survived(11 ± 3) (t = 0. 570, P = 0. 000); Time from hospital admission until plasmapheresis were significantly longer in died patients ((49 ± 9) hours) than in survived patients ((38 ± 8) hours, t = 3. 549, P = 0. 040). Furthermore, serum triglyceride levels were significantly higher in survived cases ((46 ± 16) mmol/L) than those who died ((37 ± 15) mmol/L) (t = 2. 386, P = 0. 010) . Both serum triglyceride and cholesterol levels were reduced significantly in control group (t = 3. 484, P = 0. 00; t = 4. 086, P = 0. 000, but the degrees of reduction were significantly lower than that of the treatment group. When comparing Uyghur patients to Han patients, Uyghur cases had higher serum triglyceride (t = 2. 083, P = 0. 039), and cholesterol levels (t = 2. 535, P = 0. 012, and their age was significantly younger than that of Hans (t = 3. 373, P = 0. 010 .

CONCLUSIONSs Uyghur patients with hyperlipidemia acute pancreatitis tend to have higher serum triglyceride and cholesterol levels, and age at disease onset is younger. Plasmapheresis is a more effective treatment option for patients with hyperlipidemia acute pancreatitis. Treatment outcome is related to APACHE II score, serum triglyceride levels, and time frame between admission and plasmapheresis treatment.

APACHE ; Acute Disease ; Asian Continental Ancestry Group ; Humans ; Hyperlipidemias ; complications ; therapy ; Length of Stay ; Pancreatitis ; complications ; therapy ; Plasmapheresis ; Time-to-Treatment ; Treatment Outcome ; Triglycerides ; blood

ObjectiveTo study the effects of the sand therapy of Uyghur Traditional Medicine on cytokines,such as interleukin-1β(IL-1β), tumor necrosis factor-α(TNF-α), nitric oxide(NO) of the rabbit experimental knee osteoarthritis. Methods27 rabbits were injected papain into the joint space of right knee, and divided randomly into three groups. 15 d after the articular injection, the rabbits of group Ⅰ were treated with the sand therapy, the rabbits of group Ⅱ were treated with fenbid, and Ⅲ group accepted no treatment for the blank control.15 d after treatment, the serum and the douche fluid of the diseased joints were obtained to measure the level of IL-1β,TNF-α and NO. The synovium and the cartilage was observed histopathologically.ResultsCompare with group Ⅱ and Ⅲ, the pathological changes of cartilage and synovitis in group Ⅰ lighten significantly. Compare with groupⅢ,the level of IL-1β, TNF-α in articular douche fluid and NO in serum of group Ⅰ and Ⅱ decreased significantly. ConclusionThe sand therapy can decrease the level of cytokines in the focus joints, which may play a role of treatment in osteoarthritis.

[Abstract ] Objective Modern pharmacological studies confirmed Zhigancao Decoction total extract, single active ingredients and their combinations could obviously inhibit arrhythmia.This study was to investigate the effects of Zhigancao Decoction medicated serum combined with myocardial tissue/silicon substrate microelectrode arrays (MEA) on rapid atrial pacing(RAP). Methods New Zealand white rabbits were randomly divided into normal control group, normal serum control group, Zhigancao Decoction medica-ted serum group and water decoction group, 8 in each group.After the establishment of an atrial fibrillation rabbit model, the field ac-tion potential duration ( fAPD) of the right atrial appendage ( RAA ) tissue was measured and the effections of Zhigancao Decoction medicated serum and water decoction on the fAPD of RAA were observed. Results The successful modeling of rapid atrial pacing induced atrial fibrillation in rabbits contributed to the significant shortening of fAPD 12 h after pacing compared to that before pacing ([174.30 ±1.36]ms vs[162.48 ±0.88]ms, P<0.05).After giving 10%~25% Zhigancao Decoction medicated serum and water decoction, the fAPDs of RAA tissue in rabbits with atrial fibrillation were prolonged, which represented positive dose-response relation-ship.The fAPDs of the rabbits given serum containing 10%, 15%, 20%and 25%Zhigancao Decoction were respectively (170.81 ± 0.61)ms, (171.00 ±0.46)ms, (179.08 ±0.67)ms, (179.76 ±2.26)ms, which were longer than those of water decoction group ([163.82 ±0.780]ms, [163.66 ±0.95]ms, [174.06 ±1.32]ms, [176.84 ±1.19]ms), and the difference was statistically sig-nificant (P<0.05). Conclusion The fAPD can be taken as one index of cardiac electrophysiological change, and 10%~25%Zh-igancao Decoction medicated serum can lead to fAPD extension in rabbit model of atrial fibrillation, which might be the electrophysio-logical mechanism of anti-atrial fibrillation.

China ; Humans ; Serogroup ; Shigella

Objective: To observe assessment effects of thromboelastogram (TEG) on patients with coronary heart disease (CHD) complicated hypertension.Methods: A total of 120 CHD patients were selected from our hospital.According to complicated with hypertension or not, they were divided into pure CHD group (n=58) and CHD + hypertension group (n=62).TEG indexes were compared between two groups.Results: Compared with pure CHD group, there were significant reductions in blood clot formation duration [K: (2.53±0.72)min vs.(1.82±0.64)min], coagulation reaction duration [R: (8.66±1.86)min vs.(7.18±1.85)min], arachidonic acid pathway-induced platelet activity [AA: (57.36±16.91)% vs.(46.73±20.73)%], and significant rise in maximum amplitude after clot formation [MA: (57.31±7.75)mm vs.(64.36±7.85)mm] and included angle value between the tangent from the blood clot forming point to the maximum curve radian of the chart and the horizontal line [Angle: (53.26±7.78) vs.(64.38±7.85)] in CHD + hypertension group, P<0.01 all.Spearman correlation analysis indicated that blood pressure level was significantly positive correlated with Angle and MA (r=0.607, 0.405, P<0.01 both), and significantly inversely correlated with R and K (r=-0.256,-0.541, P<0.01 both) in CHD + hypertension patients.Conclusion:Thrombosis possesses higher risk for CHD + hypertension patients, which is easier to cause acute cardiovascular events.Therefore, attention should be paid to coagulation function monitoring in order to prevent adverse cardiac events in these patients.

BACKGROUND:On the basis of modern design method and numerical simulation, studies can explore the action mechanisms of sand therapy in Uyghur medicine.
OBJECTIVE:To explore a kind of non-homogeneous and isotropic biological bone finite element modeling method based on CT value, and to study the influence of sand therapy in Uyghur medicine on the mechanical properties of rabbits’ femur.
METHODS:Eight adult New Zealand white rabbits were used to establish osteoarthritis models of right posterior femur with papain. These rabbits were divided into sand therapy group and control group. In the sand therapy group, after treatment with sand therapy in Uyghur medicine, rabbit femoral models were scanned with CT. The fault image data were imported into MIMICS software. 3D model of femur was generated. The meshing was done. The material properties were given. Three-point bending in the Ansys was simulated and solved.Simultaneously, the isolated three point bending tests were performed in al rabbit models. The corresponding deflection and the maximum stress values were obtained. Finaly, the results obtained from the three-dimensional finite element modeling method were compared with the results obtained from the experiments.
RESULTS AND CONCLUSION:(1) The deflection and the maximum stress obtained by the three-point bending simulation analysis with the three-dimensional finite element model of the rabbits’ femur were wel correlated with the data obtained from the experiments. (2) These results indicate that the finite element modeling method is consistent with the structural and material properties of bone, which can be used to analyze the stress and deformation ofbones.

Objective To evaluate laparoscopic radical resection of liver hydatid cyst as compared with conventional open surgery.Methods From May 2006 to January 2013 clinical data of 41 patients undergoing laparoscopic radical resection of hepatic hydatid cyst were compared with those 112 cases treated by open surgery.Operation time,blood loss,conversion rate,length of hospitalization and recurrence rate were compared and analyzed.Results There was not statistical significant difference in operative time and blood loss between the two groups (t =1.97,P ＞ 0.05) (t =2.00,P ＞ 0.05).Five laparoscopic patients were converted to open surgery,conversion rate was 12.2 ％ (5/41),three due to inadequate exposure,and two for intraoperative bleeding.Postoperative hospital stay was significantly shorter in laparoscopic group than that in conventional group.The overall morbidity was 4.9％ (2/41) in laparoscopic and 16.0％ (18/112) in conventional group with statistical significance(x2 =3.92,P ＜ 0.05).Recurrence rate and mortality was 0 in both groups.Conclusions Laparoscopic radical resection of hydatid cyst is safe and effective in carefully selected patients and provides short hospital stay,good cosmetic result,fast recovery and fewer complications.

OBJECTIVE: To determine the effect of sand therapy on the changes the femur mechanical properties of arthritis in rabbits in treatment. METHODS: Right knees of New Zealand rabbits were fixed for 6 weeks by plaster, and taken off after 6 weeks. The rabbits were divided into a sand therapy group and a control group. The sand therapy group was treated for 20 d, the control group did not receive any treatment. After 20 days, 7 workpieces were taken from the sand therapy group, and 5 from the control group. After compression experiment, sigma-epsilon curves were obtained.Finite element method was used to analyze the stress cloud and the deformation cloud. RESULTS: The sand therapy group showed high compressive strength. The stress of the control group was lower than that of the sand therapy group (P<0.05). When the surface materials were destroyed, the workpieces from the sand therapy group still bore large load, which matched the property that bone material was a typical multi-storey composite material. The stress cloud also found that the long axle suffered larger stress than the short axle, and the workpieces were more likely destroyed from the long axle. CONCLUSION Sand therapy can improve the mechanical properties of the bone.
Animals ; Femur ; physiopathology ; Finite Element Analysis ; Hot Temperature ; therapeutic use ; Knee Joint ; Male ; Medicine, Chinese Traditional ; methods ; Osteoarthritis ; metabolism ; therapy ; Rabbits ; Random Allocation ; Silicon Dioxide ; Stress, Mechanical ; Tensile Strength

Abstract A suspected case of cutaneous anthrax was reported by Gongliu County Disease Control and Prevention Center, Ili Kazak Autonomous Prefecture, Xinjiang Uygur Autonomous Region on August 19, 2021. Then, an epidemiological survey was performed by a joint investigation team consisting of professionals from Xinjiang Uygur Autonomous Region Center for Disease Control and Prevention, intermediate-level trainees from the Field Epidemiology Training Program of Chinese Center for Disease Control and Prevention, and professionals from Ili Kazak Autonomous Prefecture Center for Disease Control and Prevention. A total of 11 cutaneous anthrax cases were identified, including 8 suspected cases and 3 clinically diagnosed cases, and all cases were villagers in Y Village, X Township, Gongliu County, without severe case or deaths found. The onset of the first case occurred on July 27, and the onset of the last case occurred on August 16. The main clinical manifestations included ulcerative eschar on hands and exposed skin of the upper extremity. A Bacillus anthracis isolate was detected in meat samples from infected cattle. Epidemiological surveys showed that villagers did not report infected cattle to related sectors and privately slaughtered and ate meat from infected cattle without any effective protective measures, resulting in this outbreak. It is recommended to strengthen health education for people raising, selling and slaughtering livestock, and publicize zoonotic disease control knowledge, including anthrax, and establish an effective surveillance and response system for anthrax for immediate identification and treatment of epidemics.

OBJECTIVETo study the effects of sand treatment on cysteine aspartate-specific proteinase-3 (Caspase-3), B-cell leukemia-lymphoma-2 (Bcl-2), Bcl-2-associated X protein gene (Bax) in the articular cartilage of rabbit knee osteoarthritis (OA), and the apoptotic protein expression, thus providing theoretical evidence for sand treatment in Uyghur medicine.

METHODSThe OA animal model was established by fixing right hind limbs with gypsum in 22 New Zealand rabbits. Of them, 2 original model rabbits were taken as the control group, while the rest 20 were randomly divided into a free running group and a sand treatment group, 10 in each group. The healthy side of the free running group was taken as the normal control group. The sand treatment was given to those in the sand treatment group for 20 days. The expressions of Caspase-3, Bcl-2, and Bax in the cartilage cells of rabbit knee joint were measured by immunohistochemical assay. The cell apoptosis of chondrocytes was detected using terminal deoxynucleotidyl transferase mediated dUTP nick end labeling (TUNEL).

RESULTSCompared with the normal control group, the positive cell number, the optical density (OD), the protein expressions of Caspase-3, Bax, and TUNEL were higher in the free running group and the sand treatment group (P < 0.01). Besides, they were obviously higher in the free running group than in the sand treatment group (P < 0.01). The positive cell number of Bcl-2 and OD value in the free running group and the sand treatment group were both lower than those of the normal control group (P < 0.01). The positive cell number was obviously higher in the sand treatment group than in the free running group (P < 0.01).

CONCLUSIONSand treatment could inhibit the expressions of Caspase-3, Bax/Bcl-2, and TUNEL in the articular cartilage of rabbits' knee OA, which might be partial mechanisms for anti-inflammation of sand treatment.

Animals ; Apoptosis ; Cartilage, Articular ; metabolism ; Caspase 3 ; metabolism ; Chondrocytes ; metabolism ; Female ; Medicine, Chinese Traditional ; methods ; Osteoarthritis, Knee ; metabolism ; therapy ; Proto-Oncogene Proteins c-bcl-2 ; metabolism ; Rabbits ; bcl-2-Associated X Protein ; metabolism