Magaldrate (malumix) is a chemical combination of magnesium and aluminum hydroxides used an antacid. It has a rapid action, high acid consuming capacity. Studies in vitro showed that magaldrate (malumix) possessed some antipepsin activity. At pH = 1.5 proteolysis was inhibited 55% by malumix. Pretreatment with Malumix suspension 30 minutes before ethanol reduced the severity and extent of gastric mucosal lesions at dose-dependent manner. Magaldrate (malumix) had not acute toxicity in vivo test.
Peptic Ulcer ; Therapeutics ; Magaldrate ; Pharmaceutical Preparations