Objective To investigate the effects of peroxisome proliferator activated receptor γ(PPARγ) agonists pioglitazone combined with radiotherapy on colon carcinoma xenograft in mice.Methods The colon cancer cells CT26 of mouse were inoculated in the right side of the rib loins of BALB/c mouse.Established BALB/c mice tumor models.The mice were randomly divided into six groups:untreated group,tumor contral group,DMSO group,pioglitazone treated group,radiotherapy group,radiotherapy combined with pioglitazone treated group.To observe the tumor growth of each group,to compute and compare to the tumor inhibition rates.the pathological varieties of the tumor were observed.Results The tumor volumes were compared with each group after two weeks of radiotherapy.Compared with tumor contral group,pioglitazone treated group,radiotherapy group and radiotherapy combined with pioglitazone treated group could decrease the volume of tumor (P =0.008,P =0.001,P =0.001).Compared with pioglitazone treated group,the effect of radiotherapy group or radiotherapy combined with pioglitazone treated group was more evident (P =0.026,P =0.018).Contrasted with radiotherapy group,radiotherapy combined with pioglitazone treated group had no significant difference (P =0.335).The tumor inhibition rates of pioglitazone treated group,radiotherapy group and radiotherapy combined with pioglitazone treated group were 46.30 ％,68.60 ％ and 70.01％.The pathological varieties of tumor were obvious.Conclusion Pioglitazone,radiotherapy and radiotherapy combined with pioglitazone could inhibit the growth of tumor.PPARγ is a new target for tumor treatment.

Objective To study the clinical features, laboratory index and therapy of hypoplastic myelodysplastic syndrome. Methods 8 patients with hypoplastic MDS by using the method of bone marrow smear and bone marrow biopsy were studied. T lymphocyte subsets were analyzed by flow cytometry. 8 patients were treated with personalized therapy. Results All the patients of this group had hypoplastic bone marrow with more than two parts, bone marrow hypocellularity and characteristics of ineffective hematopoiesis. The analysis of T lymphocyte subsets showed that 5 of 8 patients had abnormal CD+4/CD+8 ratios. After personalized treatment, there were 2 obvious remission cases, 3 partial remission cases, 2 progression cases and 1 inefficacy case. Conclusion Hypoplastic MDS is characterized by bone marrow hypocellularity and ineffective hematopoiesis, which showed immunological abnormalities. Personalized therapeutic strategy may prolong survival in patients with hypoplastic MDS.

Chemical synthetic drugs are the main therapeutic drugs for cancer, however, the time-consuming drug development, lengthy treatment, serious side effects and drug resistant of chemical synthetic drugs significantly increase the burden of the patients.In recent years, natural anti tumor substances with good treatment effectiveness and low toxicity, have attracted more and more attentions in studying anti tumor drugs.It is reported that Inonotus obliquus can significantly suppress tumors, while the antitumor components and mechanisms of Inonotus obliquus are rarely reported.In this paper, we will review the antitumor effect, antitumor components and mechanisms of Inonotus obliquus.

Objective To assess the effectiveness and safety of acupuncture and moxibustion for treatment of vertebrobasilar insuffciency (VBI). Methods Randomized controlled trails (RCTs) of VBI treated by acupuncture and moxibustion were collected. 8 RCTs were included and assessed. The data was statistically analyzed by Meta-analysis and Funnel plot analysis. Result 8 RCTs were all trails of low methodological quality. Meta-analysis indicated after combination OR=4.36, confidence interval of 95% was 2.88～7.45. The rhombus was located at the right side of the medium line (Z =6.33, P

Objective To observe the effect of enteral nutritional emulsion on nutritional status and immune function in patients with gastrointestinal cancer. Methods From January 2014 to January 2017,100 patients with gastrointestinal cancer in Yuncheng Central Hospital were selected in the research and randomly divided into two groups according to the digital table, with 50 cases in each group. All the patients underwent chemotherapy, the observation group was given enteral nutritional emulsion during chemotherapy. The indicators of nutritional status, immune function, the effect of chemotherapy, the incidence of adverse reactions were compared between the two groups. Results After treatment,the prealbumin,albumin,transferrin and hemoglobin levels in the observation group were (0. 30 ± 0. 07)g/ L,(32. 93 ± 1. 67)g/ L,(2. 61 ± 0. 15)g/ L,(109. 94 ± 2. 31)g/ L,respectively,which in the control group were (0. 19 ± 0. 09)g/ L,(30. 89 ± 1. 49)g/ L,(2. 49 ± 0. 14)g/ L,(108. 07 ± 2. 04)g/ L,respectively, there were statistically significant differences between the two groups(t = 6. 822,6. 445,4. 135,4. 291,all P < 0. 05). After treatment,the CD +3 ,CD4 / CD8,NK cells in the observation group were (43. 84 ± 7. 65)％ ,(1. 70 ± 0. 18) and (37. 78 ± 7. 51)％ ,respectively,which in the control group were (36. 12 ± 6. 57)％ ,(1. 52 ± 0. 19) and (31. 07 ± 4. 20)％ ,respectively,there were statistically significant differences between the two groups ( t = 5. 413,4. 863, 6. 124,all P < 0. 05). The objective response rate of the observation group (64％ ) was significantly higher than that of the control group(44％ )(χ2 = 4. 026,P < 0. 05). The incidence rate of adverse reaction of the observation group (18％ ) was significantly lower than that of the control group(36％ )(χ2 = 4. 110,P < 0. 05). Conclusion Enteral nutritional emulsion can effectively improve the nutritional status and immune function of patients with gastrointestinal cancer during chemotherapy,but also can effectively enhance sensitivity to chemotherapy,improve the effect of chemo-therapy,and the safety is reliable.

Objective To investigate the correlation among HBV infection models,HBV Pre-S1 antigen and HBV DNA loads in serum and to provide evidence for the diagnosis and treatment of hepatitis B.Methods Hepatitis B markers,HBV Pre-S1 antigen and HBV DNA loads in serum samples were detected simultaneously for 1037 cases.Results The positive rate of HBV Pre-S1 antigen was higher in HBsAg,HBeAg and HBcAb positive model than that in other models(P0.05).Conclusion The quantitative detection of HBV DNA is important for the prevention of HBV infection.The combination assay of serum HBV markers,Pre-S1 antigen and HBV DNA load was beneficial to the monitoring of disease condition of hepatitis B and to the improvement of therapeutic effect.

Objective To understand the prevalence rate of mild cognitive impairment(MCI) of the aged people in the communities of Taiyuan,and to provide evidence for early diagnosis of Alzheimer's disease(AD). Methods Using a simple mental state examination(MMSE),2895 aged people of over 60 years from three communities of Wanbailin in Taiyuan were selected by cluster random sampling method.The MCI elderly patients screened were investigated further by using community health status questionnaire.Results The average MCI prevalent rate of the aged people was 7.6%;Age,marital status and education background significantly affected prevalent rate(P

Objective To study the effect of Busui Jiannao Prescription on ethology, GSH content and GSH-PX activity in brain of PD model rats. Methods Forty-five the aging pure C57BL rats were divided into a negative injury group, a model group, and a Chinese medicine group. PD animal model were established by injection with MPTP and were treated with Busui Jiannao Prescription by intragastric administration. Score changes of PD model rats in the test of pole-climbing and suspending were observed. GSH content and GSH-PX activity were further measured. Results After treating with Busui Jiannao Prescription, the test scores in pole-climbing and suspending were improved, GSH content and GSH-PX activity in substantia nigra were increased. Conclusion Busui Jiannao Prescription can regulate the behavior coordination and repair the damage of dopaminergic neurons in the substantia nigra of PD model rats.

Objective To evaluate the clinical outcome of hip arthroplasty following femoral neck fracture.Methods Sixty-one cases of femoral neck fracture were treated by hip arthmplasty from January 2000 to April 2008,and their complete data were available,whose age ranged from 36 to 90 years old,mean age(71.5±14.7)years old.The group comprised 21 men and 40 women.Results Clinical follow-up ranged from 3 months to 8 years.The Harris hip score improved from(17.5±8.4)scores pre-operatively to(78.1±8.5)scores post-operatively,and the average leg-length discrepancy decreased from(2.52±1.09)cm pre-operatively to(0.81±0.73)cm post-operatively.The differences between pre-operative data and post-operative data were significant (P＜0.05).Conclusion Hip arthroplasty is an ideal procedure for old femoral neck fracture in elderly patients or those who followed failed previous treatment.

Objective To investigate risk factors and characteristics of the pathogens for hospital-acquired pneumonia(HAP) in elderly psychiatric patients Methods Data were collected from 259 psychiatric patients aged over 60 hospitalized between January 2012 and December 2014,and risk factors for HAP and characteristics of the pathogens were analyzed.Results The incidence of HAP in the elderly psychiatric patients was 40.4％.Main risk factors for HAP included long-term bed rest,dysphagia,specific types of mental illness,underlying comorbidities,length of hospitalization,psychiatric medications,and age.A total of 137 pathogenic microbialstrains were isolated,of which,Gram-negative species accounted for 55.47％,with 32.12 ％ as Gram-positive species and 12.41 ％ as fungal species.Conclusions The main risk factors for HAP in elderly psychiatric patients are long-term bed rest,dysphagia,specific types of mental illness,underlying comorbidities,length of hospitalization,psychiatric medications,and age.The most common pathogens are Gram-negative microorganisms,followed by Gram-positive microorganisms and fungi.It is very important to take proactive measures to prevent the occurrence of HAP and improve prognosis.