Bronchoscopy ; Humans ; Pneumonia, Mycoplasma ; diagnosis ; pathology ; surgery

Adolescent ; Adult ; Barotrauma ; complications ; Female ; Humans ; Male ; Middle Aged ; Occupational Diseases ; etiology ; therapy ; Sinusitis ; etiology ; therapy ; Young Adult

Objective To observe and investigate the effect of esomeprazol in the elderly patients with gastric ulcers and influence for the pepsinogen,cAMP and cGMP.Methods 86 elderly patients with gastric ulcers in our hospital from June 2015 to August 2016 were selected as the research object,and they were randomly divided into control group 43 cases and observation group 43 cases, the control group were treated with omeprazole,the observation group were treated with esomeprazol,the total effective rates,symptom score and pepsinogen, cAMP, cGMP levels before and after the treatment of two groups were compared.Results The total effective rates of observation group at different time after the treatment were higher than those of control group,the symptom scores after the treatment were all lower than those of control group ,the serum pepsinogen were all lower than those of control group,the plasma cAMP and cAMP /cGMP were lower than those of control group,the plasma cGMP were higher than those of control group, (P<0.05), the differences were all significant.Conclusion The clinical effect of esomeprazol in the elderly patients with gastric ulcers is better,and it can significantly improve the expression situation of pepsinogen, cAMP and cGMP of patients, so its application value in the elderly patients with gastric ulcers is higher.

OBJECTIVE:To provide references for avoiding "government malfunction" in the transition stage of pharmaceutical industry in China and to enhance the efficacy of government control.METHODS:The manifestation and cause of government malfunction in the transition stage of pharmaceutical industry in China were analyzed,and the countermeasures aimed at the problems were put forward.RESULTS & CONCLUSIONS:To avoid government malfunction arose from power rent-seeking,governments' low efficiency imperfect price system etc so as to guarantee a smooth transition of pharmaceutical industry,the function of government should be altered,the efficiency of government should be improved and reasonable drug price management system should be established.

Building a harmonious relationship between doctors and patients must resolve disharmony.Above all,resolving disharmony must clear about the most important reason that results in disharmony is not to know that patients play the most important role in the doctors' curing process.So far doctors and patients must make a point of the most important role of patients.Doctors must leave no stone unturned to mobilize patients' go-aheadism.Patients must positively cooperate with doctors,exert the most important role to cure and return to health.

Objective To explore the evaluation of tumor specific growth factor (TSGF) ,alpha‐fetoprotein (AFP) and vascular endothelial cell growth factor(VEGF) levels in therapeutic effect of primary hepatic carcinoma (PHC) .Methods Serum TSGF , AFP and VEGF levels were detected on 1 d before treatment ,4 ,28 d after treatment in 75 patients with PHC .The relation between serum VEGF with AFP on 1 d before treatment was analyzed .Results The levels of serum TSGF ,AFP and VEGF on 4 ,28 d after treatment in 75 cases of PHC were significantly lower than those on 1 d before treatment ,the difference was statistically significant (P< 0 .05) .The VEGF level had no statistical difference between the patients with AFP ≥ 400 ng/mL and the patients with AFP <400 ng/mL(P> 0 .05) .Conclusion TSGF ,AFP and VEGF can serve as the indicators for evaluating PHC prognosis .

Objective: To study the inhibition effect of survivin antisense oligodeoxynucleotide (ASODN)on apoptosis and invasion of hilar cholangiocarcinoma cell line FRH-0201. Methods: ASODN was transfected into cholangiocarcinoma cell line FRH-0201 by LipofectamineTM2000. The level of MMP-2 and TIMP-2 in the supernatant was detected by enzyme linked immunosorbent assay (ELISA). The effect of ASODN transfection was observed by Transwell cell culture chamber. Results: The cell proliferation was inhibited in the ASODN group. The expression of MMP-2 in ASODN group was lower than those in the SODN and blank group (P

Four kinds of commonly used injections and four refined components of the tranditional Chinese medicinals as well as one synthetic remedy, CMS or 404, have been studied for the immunoregulatory effects by using in vitro antibody cresponse system of Mishell and Button and by direct hemolytic plaque assay of Jerne. The results showed that among the injection remedies, 0.05-5% Baphica-canthes cusia, Brenk, and Leonurus heterophyllus, sweet, had immunosuppressive effects with little effect on cell viability, while 0.0005% of the former remedy showed immunopotentiation; 0.05-5% salvia miliorrhiza,Bge, had immunosuppresive effect with greater inhibitory effect on cell viability; Gentiana scabra, Bge, had weaker immunosuppressive effect (0.5-5%) with stronger inhibitory effect on cell viability. Among refined components, 0. 1?g/ml of Mangiferin showed immunosuppres-sion with no action on cell viability. Both Emodin monoglucoside and paeonol had weaker immunosuppressive effect (50-100?g/ml) and markedly affected cell viability; Acanthopanax senticosus polysaccharide (PES) showed immunosuppression in higher concentration (500?g/ml) and marked immunopotentiation at lower concentration (0.01-100?g/ml) with no effect on cell viability. A synthetic remedy, carboxymethylated starch (CMS or 404) had markedly immunopotentiating effect at 0.01-500?g/ml with no harmful effect on cell viability. The experiment revealed that in order to induce antibody in vitro, the adherent cells were necessary. Discussions have been made on the role of adherent cells in helping antibody response in vitro, and an evaluation on the advantages and disadvantages of the in vitro tests used for study of immunoregulatory drugs.

In order to evaluate the effect of riboflavin on thyroid hormone levels in the blood of rats during cold exposure, male adult rats were divided randomly into six or eight groups. The group 1,2,5 and 6 were supplemented with 1.5mg riboflavin per kg basal diet, but the group 3, 4, 7 and 8 with 6.0mg riboflavin per kg basal diet. The group 1, 3, 5 and 7 were kept at the cold room (4?0.5) and the group 2,4,6 and 8 at room temperature. The results revealed that supplementation of riboflavin to cold exposed rats could raise the lowered T4 concentration of serum and shorten the time of T4 returned to its original levels. Therefore, riboflayin could hasten cold acclimatization of organism.

This report describes the effects of a new radiosensitizer, metronidazole derivative (CM) synthesized in our laboratory, on membrane permeability of 51Cr labelled L7712 cells.It was found that CM could be incorporated into the cancer cells easily, and resulted in increased membrane permeability.Under aerobic condition, the release rate of 51Cr was increased when the cells were irradiated with more than 40 Gy Y-rays.At a dose of 0-80 Gy, the sensitization effects of CM on membrane permeability of irradiated cells were not found.