1.A Case of Uterine Pseudoaneurysm Rupture After Cesarean Surgery, Treated by Uterine Artery Embolization
Manabu KOJIMA ; Soichi NAKAMURA ; Kenichi KATO ; Ryuji YAMAUCHI
Journal of the Japanese Association of Rural Medicine 2013;62(2):135-139
Pseudoaneurysm of the uterine artery is rare as a cause to delayed postpartum hemorrhage. Nowadays, uterine pseudoaneurysm is often treated by uterine artery embolization. The outcome is favorable. Here, we report a case of delayed postpartum hemorrhage following Cesarean section, which was caused from a rupture of uterine pseudoaneurysm. The patient was at the point of death from excessive bleeding but successfully treated by uterine artery embolization (UAE). In encountering a case of postpartum hemorrhage after Cesarean delivery or Dilation & Curettage, it is indispensable to check the abnormal blood flow in a color Doppler examination.
2.Aortic Valve Replacement for Aortic Stenosis in Patients 70 Years and Older
Yasuyuki Kato ; Shigefumi Suehiro ; Toshihiko Shibata ; Yasuyuki Sasaki ; Hidekazu Hirai ; Kenu Fumimoto ; Yasuyuki Bito ; Manabu Motoki ; Yosuke Takahashi
Japanese Journal of Cardiovascular Surgery 2005;34(6):389-394
We studied 73 patients, 70 years of age or older, who underwent aortic valve replacement for aortic stenosis between October, 1990 and October, 2004. There were 31 men and 42 women with a mean age of 75.7±3.6 years. Mechanical valves were implanted in 37 patients, and bioprostheses in 36 patients. Operative mortality was 1 of 73 (1.4%) and the New York Heart Association functional class improved to class I or class II in all of the hospital survivors. Follow-up (100%) extended from 0.3 to 11.6 years (mean 3.7 years). There were 16 late deaths (5.9% per patient-year), including valve-related deaths in 6 patients. The overall survival rates at 5 and 10 years was 74.2% and 44.3%, respectively. The freedom from valve-related events at 5 and 10 years was 78.8% and 78.8%, respectively. The 10-year survival rates and freedom from valve-related events were not different between the patients with mechanical valves and those with bioprostheses. The size of the implanted valve did not influence the late survival or freedom from valve-related events. The outcome after aortic valve replacement in the elderly (70 years and older) was excellent with low operative mortality, and acceptable late mortality and morbidity. Thus, aortic valve replacement for elderly patients should have the same indications as for younger patients. Bioprostheses showed good long-term results with no structural valve deterioration, thromboembolism, or bleeding events. Mechanical valves, which required the maintenance of an anticoagulant therapy, were also useful with acceptable late morbidity. The long-term results with small valves (≤19mm) were comparable to the results with large valves (>19mm) in the elderly. Thus, the use of these small valves in this particular age group seems to be acceptable.
3.The Study on the Process and Problem for Transfer of Patients Infected with HIV to the Long-term Care Hospital Through Two Cases
Kazuhisa YOKOTA ; Takashi MURAMATSU ; Hiromoto KATO ; Yoshiko KAMIKUBO ; Akito ICHIKI ; Yushi CHIKASAWA ; Masato BINGO ; Mihoko YOTSUMOTO ; Manabu OTAKI ; Takeshi HAGIWARA ; Kagehiro AMANO ; Katsuyuki FUKUTAKE
An Official Journal of the Japan Primary Care Association 2018;41(2):65-67
4.An Approach to Delivering Prophylactic Rehabilitation Interventions to Individuals in a Rural Area
Yusuke KATO ; Manabu HORI ; Nobuyuki HAYASHI ; Hideto TSUKAMOTO
Journal of the Japanese Association of Rural Medicine 2020;68(5):623-
We started a prophylactic rehabilitation class from fiscal year 2016 and 1 year later we identified 4 problems, namely, a small number of participants (mean, 4.6), a small male population (ratio of 1 male to 9 females), no follow up because only 1 session was given per area, and a low home exercise rate (42.5%). For the class in fiscal year 2017, discussions were held with the comprehensive regional support center. Accordingly, relevant information was disseminated via public relations magazines, neighborhood circulars, and the local government to address the problems with the number of participants and sex ratio, and a series of 4 sessions were held per area to address the problems with the lack of follow-up and continuation of home exercise. Objective assessments (grip strength, one-leg standing, and knee extension strength) were included in the physical assessment. Through these measures, based on questionnaire results, we found that there was an increase in the number of participants and that more participants continued the exercise at home after the class was increased.
5.A Practical Grading Scale for Predicting Outcomes of Radiosurgery for Dural Arteriovenous Fistulas: JLGK 1802 Study
Hirotaka HASEGAWA ; Masahiro SHIN ; Jun KAWAGISHI ; Hidefumi JOKURA ; Toshinori HASEGAWA ; Takenori KATO ; Mariko KAWASHIMA ; Yuki SHINYA ; Hiroyuki KENAI ; Takuya KAWABE ; Manabu SATO ; Toru SERIZAWA ; Osamu NAGANO ; Kyoko AOYAGI ; Takeshi KONDOH ; Masaaki YAMAMOTO ; Shinji ONOUE ; Kiyoshi NAKAZAKI ; Yoshiyasu IWAI ; Kazuhiro YAMANAKA ; Seiko HASEGAWA ; Kosuke KASHIWABARA ; Nobuhito SAITO ;
Journal of Stroke 2022;24(2):278-287
Background:
and Purpose To assess the long-term outcomes of intracranial dural arteriovenous fistula (DAVF) treated with stereotactic radiosurgery (SRS) alone or embolization and SRS (Emb-SRS) and to develop a grading system for predicting DAVF obliteration.
Methods:
This multi-institutional retrospective study included 200 patients with DAVF treated with SRS or Emb-SRS. We investigated the long-term obliteration rate and obliteration-associated factors. We developed a new grading system to estimate the obliteration rate. Additionally, we compared the outcomes of SRS and Emb-SRS by using propensity score matching.
Results:
The 3- and 4-year obliteration rates were 66.3% and 78.8%, respectively. The post-SRS hemorrhage rate was 2%. In the matched cohort, the SRS and Emb-SRS groups did not differ in the rates of obliteration (P=0.54) or post-SRS hemorrhage (P=0.50). In multivariable analysis, DAVF location and cortical venous reflux (CVR) were independently associated with obliteration. The new grading system assigned 2, 1, and 0 points to DAVFs in the anterior skull base or middle fossa, DAVFs with CVR or DAVFs in the superior sagittal sinus or tentorium, and DAVFs without these factors, respectively. Using the total points, patients were stratified into the highest (0 points), intermediate (1 point), or lowest (≥2 points) obliteration rate groups that exhibited 4-year obliteration rates of 94.4%, 71.3%, and 60.4%, respectively (P<0.01).
Conclusions
SRS-based therapy achieved DAVF obliteration in more than three-quarters of the patients at 4 years of age. Our grading system can stratify the obliteration rate and may guide physicians in treatment selection.
6.Effects of TGF-β1 on the migration of oral cancer-associated fibroblasts in two and three dimensional co-culture models
YANG Jin ; WU Feifei ; GAO Qinghong ; LI Xiaoyu ; MANABU Kato ; CHENG Ran ; ZHOU Hongmei
Journal of Prevention and Treatment for Stomatological Diseases 2020;28(9):562-568
Objective:
To observe the effect of transforming growth factor-β1 (TGF-β1) on the migration of oral carcinoma associated fibroblasts (CAFs) with two-dimensional culture model and three-dimensional model.
Methods :
Under two-dimensional culture conditions, CAFs stimulated by TGF-β1 with the addition of 10 ng/mL medium were used as the experimental group, and untreated CAFs were used as the control group. The migration of CAFs with the stimulation of TGF-β1 was measured by cell scratch assay and transwell assay. CAFs positive for green fluorescent protein (GFP) were cultured by retrovirus transfection. Human tongue squamous cell carcinoma cells SCC25, GFP(+) CAFs and CAFs with three-dimensional cell co-culture models were established. The three-dimensional model cultured under the stimulation of TGF-β1 with 10 ng/mL medium was used as the experimental group, and the three-dimensional model without TGF-β1 was used as the control group. The migration of CAFs with the stimulation of TGF-β1 was also measured by the three-dimensional models.
Results:
It was verified that 10 ng/mL TGF-β1 promoted the migration of CAFs in the two-dimensional culture model. The three-dimensional co-culture models of SCC25, GFP(+) CAFs and CAFs were successfully established. The migration of SCC25 and CAFs was detected in the three-dimensional model. However, 10 ng/mL TGF-β1 had little effect on their migration.
Conclusion
The effect of TGF-β1 in vitro on the migration of oral CAFs was associated with different culture models in two and three dimensions.