Objective:To investigate the Acinetobacter baumannii’s distribution feature、the antimicrobial resistance of Acinetobacter baumannii isolated during the past 4 years and compare antibacterial activity of Polymyxin B against multidrug-resisitant(MDR) Acinetobacter baumannii with that of Imipenem in vitro.Methods:The distribution feature of infection caused by Acinetobacter baumannii was supervised.Disk diffusion test was used to study the antimicrobial agents resistance of Acinetobacter baumannii and transition of drug resistance.The results were evaluated based on Clinical and Laboratory Standards Institute(CLSI).The MDR Acinetobacter baumannii were screened by WHONET 5.MICs(minimal inhibitory concentration)of Polymyxin B and imipenem were detected by broth dilution method.Results:Constituent ratio of infections caused by Acinetobacter baumannii had been incresed in the recent 4 years,especially in intensive care unit.Although carbapenems were the most active antibiotics tested against Acinetobacter baumannii,the resistance rate had been sharply raised since 2008.In addition,the ratio of MDR Acinetobacter baumannii had also been raised in the 4 years.The results of MIC displayed that Polymyxin B had the higher antibacterial activity against the MDR Acinetobacter baumannii than Imipenem. Conclusion:Proportion of nosocomial infection caused by Acinetobacter baumannii significantly increased.The resistance rate of Acinetobacter baumannii had been rised obviously and the number of MDR Acinetobaeter baumannii had been increased sharply. Monitoring of the antimicrobial agents resistance to Acinetobacter baumannii should be strengthened.Polymyxin B still shows strong antibacterial activity on the MDR Acinetobacter baumannii in vitro.We can consider using Polymyxin B to treat the severe infections caused by MDR Acinetobacter baumannii.

Objective To investigate the low doses of 131 iodine on serum Ghrelin levels and serological related indexes in pa‐tients with hyperthyroid .Methods A randomized controlled trials ,96 cases of hyperthyroidism in our hospital were randomly divid‐ed into two groups (group A and group B)according to the ratio of 1∶1 from June 2011 to June 2012 ,48 cases in each group ,and at the same time ,42 cases health people as health control group .The group A were treated with 131 iodine solution 3 .69 -4 .40 MBq/g reatment ,group B was given 131 iodine solution 2 .59-2 .96 MBq/g treatment ,and the serum Ghrelin levels and serological related indicators of two groups patients were statistically analyzed after treatment .Followed up for 2 years ,review of the serum levels of Ghrelin and serological related indexes and compare the incidence of hypothyroidism .Results The serum FT3 ,FT4 and FPG levels of hyperthyroid patients were significantly higher than the health control group (P< 0 .01);conversely ,the serum S‐TSH and Ghrelin levels of hyperthyroid patients were significantly lower than the health control group (P<0 .01) .3 months later after treatment ,the serum FT3 ,FT4 and FPG levels of the hyperthyroidism group B were significantly lower than hyperthyroidism group A(P<0 .05);on the contrary ,the serum Ghrelin and S‐TSH levels were significantly higher and hyperthyroidism group A (P<0 .05);2‐year follow‐up after treatment ,the incidence of hypothyroidism of hyperthyroidism group A were higher and group B ,but without statistical significance(P>0 .05) .Conclusion A low dose of oral 131 iodine solution (2 .59‐2 .96 MBq/g) ,could get a better short‐term efficacy in patients with hyperthyroidism ,high security .

Survivin is the strongest member of the inhibitor of apoptosis protein(IAP)family. Smac is the second mitochondria-derived activator of cysteine proteases,which can promote apoptosis by combining with IAP. Abnormal expression of them is closely related with occurrence,development,treatment tolerance and prognosis of ovarian cancer. It is prompted that Survivin and Smac are expected to play important roles in the early diagnosis and targeted therapy of ovarian cancer.

Objective The aim of this study was to assess the effect of hemodialysis combined with hemoperfusion for the treatment of microinflammation in diabetic nephropathy patients.Methods One hundred and twenty-five cases of diabetic nephropathy experienced treatment from July 2014 to December 2015 in author's hospital were analyzed retrospectively.They were divided into two groups randomly.The observation group received hemodialysis combined with hemoperfusion,and the control group received just hemodialysis therapy.The status of microinflammation and curative effect were compared.Results The effective rate of observation group was 60.6％,while was 45.8％ in control group (P＜0.05).Microinflammation level:compared with control group,SAA,IL-6,IL-17,IL-22,IL-1β,TNF-αand TGF-β1 status of observation group showed decreased trend (P＜0.01).Conclusion Hemodialysis combined with hemoperfusion can effectively decreased microinflammation status in diabetic nephropathy.

AIM: To establish a HPLC method for determing paeoniflorin and baicalin in Weichang Heji(Radix Paconiae alba,Radix Scutellariae,Radix et Rhizoma Khei,etc.). METHODS: The column was Ultimate XB-C_(18)(5 ?m,250 mm?4.6 mm),methanol-water-acetic acid(35∶65∶1) as the mobile phase at a flow rate of 1.0 mL/min,the detecting wavelength was at 244 nm. RESULTS: The linear range was within 25 ?g/mL-250 ?g/mL for paeoniflorin and baicalin. The average recovery rate was(98.12%) and 96.81%,respectively.RSD was 1.16% and 0.95%(n=6) respectively. CONCLUSION: The method is simple and accurate.It can be used to determine the contents of paeoniflorin and baicalin in Weichang Heji meantime.

Objective To establish the quality standard for Yuyuan Mingmu Granula. Methods Radix Et Rhizoma Notoginseng,Fructus Schisanrae Chinesis,Flos Scophorae and Fructus Forsythiae were identified by TLC. The content of loganin was determined by HPLC. Results Under the selected conditions,clear and specific spots were obtained. For content determination,the linear range of loganin was 0.084 ?g～0.840 ?g,r=0.999 9,the average recovery was 98.5 %(n=6)and RSD was 1.29 %. ConcLusion The method is proved to be simple and specialized with a good reproductivity and can be used to control the quality of Yuyuan Mingmu Granula.

The traditional acupuncture and moxibustion therapies were adopted to treat 32cases of melanoderm's peripheral facial paralysis at remission stage, the effective rate was 93.8%, indicating that acupuncture and moxibustion therapies are effective for different races.

A growing body of research concerns about the mental psychological intervention involved in the treatment of chronic pain. It still continue reported that combining with mental psychological intervention in pain management could relieve pain level, therefore improve quality of lives. Common psychological intervention including psychological and pharmacological approach and psychological behavior approach both support their efficacy

Independent component algorithm (ICA) is a method of higher-order statistics(HOS) with the study objects of multivariate random signals that are mutual independent. It aim is to transform multivariate random signal into the signal having components that are mutually independent in complete statistical sense. This article briefly introduce series of the ICA algorisms including second order blind identification, multiple unknown source extraction algorithm based on second-order statistics, as well as Informax, modified Informax, fast fixedpoint ICA and joint approximative diagonalization of eigenmatrix (JADE) algorithm that are based on HOS. At the end of the article, the performance of each algorithm is compared and its application prospect is forecasted.

Hospital modernization is closely related to hospital information systems.The paper presents the notion of information flow and argues that the quality,speed,coverage,and efficiency of information flow in a hospital are the basic elements of its development.Hospital information systems provide systematic,primary and service support for various activities in the hospital and bring about changes in the essence of hospital culture.In their efforts to strengthen their information infrastructure,modernized hospitals should observe the principles of people first,cost-effectiveness balance and sustainable development and lay equal stress on cultivating specialized information personnel and improving the level of the entire staff in manipulating information and science and technology.