1.c-Cbl Mediated Ubiquitination and Degradation of hSef
Yongming REN ; Zhili RONG ; Zhiyong LI ; Long CHENG ; Yinghua LI ; Yinyin WANG ; Fangli REN ; M.irwin DAVID ; Zhijie CHANG
Progress in Biochemistry and Biophysics 2008;35(1):43-49
Sef (similar expression to fgf genes) was identified as a feedback antagonist of FGF signaling in zerbrafish, mouse and human. Sefhas been reported to function in different ways, however the regulation of Sef stability remains unknown. The possible role of c-Cbl in the regulation of Sef protein degradation was investigated. Results from coimmunoprecipitation and immunostaining assays reveal that hSef colocalizes and interacts with c-Cbl. Data suggest that the interaction between hSef and c-Cbl results in the ubiquitination and subsequent degradation of the hSef protein. It was proposed that c-Cbl may serve as a modulator to regulate Sef protein stability during FGF signal transduction.
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