1.Serum high-sensitivity C-reactive Protein and Lipoprotein(a) Levels: A comparison between Diabetic and Non-diabetic Patients with Coronary Artery Disease
H Syed Shahid ; M I Kurdi ; A A Zohair
The Medical Journal of Malaysia 2011;66(2):113-116
Objective: The aim of this study was to compare highsensitivity C-reactive protein (hsCRP) and Lipoprotein(a) levels [Lp(a)] levels between diabetic and non-diabetic
patients with coronary artery disease (CAD). Study Design:
Cross sectional Study. Place and Duration of study: This
study was conducted in the department of Physiology of
College of Medicine & King Khalid University Hospital, King
Saud University, Riyadh between August 2006 and
December 2007. Methods: One hundred and three
individuals with CAD and 30 healthy individuals matched for
age and BMI were studied. CAD patients were divided into
two groups based on presence (n=62) and absence (n=41) of
type 2 diabetes mellitus. Overnight fasting blood samples
were collected, and analyzed for total cholesterol (TC),
Triglycerides (TG), Low density Lipoprotein (LDL) and High
density lipoprotein (HDL), Lp(a) and hsCRP. Data about CAD
severity was obtained from medical records. Results: Both
groups of CAD without and with DM had significantly
higher levels of Lp(a) [mg/dl] (25.58 ± 25.99, 25.90 ± 24.67 respectively) and hsCRP [mg/dl] (0.52 ± 0.71, 0.82 ± 0.78 respectively) when compared with healthy control subjects (Lp(a) =16.93 ± 15.34 & hsCRP=0.27 ± 0.21) [p<0.05]. Lp(a) levels between the two CAD groups were non significant.
While, hsCRP levels were significantly high in CAD with DM
compared to those without DM [p<0.05]. Gensini Score of
CAD severity was also higher in CAD with DM [67.60 ± 45.94]
than those without DM [52.05 ± 42.27, p<0.05]. Conclusion:
Elevated Lp(a) and hsCRP levels are associated specifically
with angiographically defined CAD. However, hsCRP
elevation but not Lp(a) is also associated with CAD in type 2 diabetes mellitus. Measurement of hsCRP and Lp(a) may be considered optional markers for better prediction of
cardiovascular risk.