Objective To evaluate the safety and possibility of transesophageal emergency ventricular pacing with esophageal balloonelectrode catheter.Methods Sixty four patients with critical bradyarrhythmias were divided randomly to receive either transesophagealventricular pacing with esophageal balloon electrode catheter(balloon.catheter group,n=32),or transesophageai ventricular pacing withnormal esophageal electrode catheter(normal catheter group,n=32).Pulse width(ms),current output(mA),and the success rate werecompared between the 2 groups.Results Success rate in the balloon catheter group was 87.5%,which was significantly higher thanthat in the nodal catheter group(18.7%,X2=27.7,P＜0.01).The success rate oftransesophageal ventricular pacing with esophagealballoon electrode catheter was 87.5%.The average current output(mA)was significantly lower in the balloon catheter group than thatin the normal catheter group (24.5+2.5 mA VS 53±3.4mA,P＜0.05).Conclusions Esophageal balloon electrode catheter pacing couldbecome an available teclmiqBe for transesophageal emergency ventricular pacing.

AIM: To evaluate the bioequivalence of domestic and imported anastrozole tablet. 　METHODS: According to the crossover design, each volunteer was orally given anastrozole tablets (1 mg). GC determined the drug concertrations in plasma. The linear ranges was from 0.5 to 200.0 μg*L-1 plasma (r=0.9997, n=9). The recovery rates of lower, mid, higher concentration (1.0,10.0,20.0 μg*L-1 plasma were 93.50 %, 100.17 %,98.96 % respectively. Inter-day and intra-day precisions of the method were <13 %. 　RESULTS: The pharmacokinetic parameters of the domestic and imported tablet were 1.2 h±0.5 h and 1.3 h±0.4 h for T max, 10 μg*L-1±3 μg*L-1 and 10.2 μg*L-1±2.5 μg*L-1 for Cmax, 386 μg*L-1±117 μg*L-1 and 385 μg*L-1±117 μg*h-1*L-1 for AUC0-T,36 h±14 h and 32 h±10 h for T1/2 respectively. The relative bioavailability of the domestic tablet was (100±9) %. 　CONCLUSION: Domestic and imported anastrozole tablet are bioequivalence in healthy volunteers.

Objective To investigate the molecular epidemiological characteristics of the Acinetobacter baumannii strains isolated from blood and sputum samples of patients with ventilator-associated pneumonia (VAP) in ICU.Methods The patients were analyzed in two groups:Group A,A.baumannii was isolated from both blood and sputum,and Group B,A.baumannii was isolated only from sputum.Clinical data of the patients were collected,including the results of antimicrobial susceptibility test.Pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST) were performed for the strains.Results During the study period from June 2015 to December 2105,28 nonduplicate A.baumannii strains were collected from 14 patients in group A and 28 nonduplicate strains from 28 patients in group B.The 56 A.baumannii strains were multidrug-resistant (MDR).More than 80％ of the strains were resistant to carbapenem,third-generation cephalosporins or aminoglycoside,but highly sensitive to tigecycline.No significant difference was found for the resistance rates between group A and group B.The nonduplicate A.baumannii isolates from blood and sputum samples of the same patient in group A were all homologous strains confirmed by PFGE.Six pulsotypes were identified from the 28 strains in Group A and 9 pulsotypes in Group B.Five pulsotypes were shared between the two groups.MLST analysis showed that there were 9 ST types (ST195,ST208,ST229,ST369,ST373,ST457,ST836 and two new phenotypes ST N2,ST N5) in Group A and 8 ST types (ST195,ST208,ST381 and 5 new phenotypes ST N1,ST N2,ST N3,ST N4,ST N5) strains in group B.There was no significant difference in the proportion of the main ST types between the two groups.eBURST analysis indicated that ST195,ST208,ST457,ST369,ST N1,ST N2,ST N51 belonged to CC92 prevalent strain.Conclusions The antimicrobial susceptibility profile and genotype of A.baumannii isolates from blood and sputum samples are similar.There was CC92 prevalent strain in the ward.There is no direct relation between the risk factors for bloodstream infection in VAP patients and the genotype of A.baumannii strain.It is particularly important to reinforce infection control for prevention and treatment ofA.baumannii bloodstream infections.

Objective To evaluate the value in the diagnosis of focal nodular hyperplasia( FNH) by combining micro-flow imaging ( MFI) and color Doppler flow imaging ( CDFI) . Methods A total of 32 patients with 32 FNH lesions were enrolled in this study . Each patient underwent CDFI ,MFI ,and contrast-enhanced ultrasonography ( CEUS ) examinations . The differences in the grade and characteristic distribution of blood flow in FNH were compared between CDFI and MFI . The results were further compared with CEUS . Results There was a significant difference between MFI and CDFI in detecting the blood flow in FNH . Twenty-six cases (81 .3％ ) were detected with blood flow of grade Ⅱ and Ⅲ by MFI , however , 18 cases ( 56 .3％ ) were detected of grade Ⅱ and Ⅲ by CDFI ( P = 0 .000) . A total of 12 (37 .5％ ) lesions were correctly showed spoke-wheel arterial flow peculiar by CDFI ,whereas the number increased to 23(71 .9％ ) in combination with MFI( P = 0 .013) . Conclusions In combination with MFI , CDFI can reveal more blood flow and detect more sensitively in FNH ,which helps to diagnose FNH . To a certain degree ,it can be applied to reduce the use of CEUS .

By applying "homeostasis" to the study of the meridian and collateral system， the concept of meridian and collateral homeostasis has been proposed which refers to a balanced and stable state of meridian and collateral system， and plays an important role in maintaining body health and can provide a reference for the diagnosis and treatment of diseases. Phenomics realizes the cross-scale correlation from micro-phenotypic data， such as genome， proteome， and metabolome， to macro-phenotypic data， such as physiological state， behavioral activities， and external manifestations. From the perspective of phenomics， this paper proposes a meridian and collateral homeostasis dynamic mapping model of "macroscopic signs and microscopic expression". This model combines macro signs such as the four examinations of traditional Chinese medicine （TCM）， biophysical indicators of acupoints， and micro expression information such as genes， proteins， and metabolism， and systematically investigates the relationship between meridian and collateral homeostasis and health and disease， thereby providing ideas and references for the identification of pre-disease states as well as precise diagnosis and treatment in TCM.