1.Progress of research on the pharmacological effects and mechanisms of emodin
Congyu WU ; Yue ZHOU ; Luxi SHANGGUAN ; Yani YANG ; Jingya WANG ; Junhe YU ; Shuaishuai GONG ; Junping KOU
Journal of China Pharmaceutical University 2023;54(5):634-643
As an active hydroxyanthraquinone ingredient, emodin is abundant in Chinese medicine herbs, such as Rheum palmatum, Polygonum cuspidatum and Polygonum multiflorum.Modern pharmacological studies have shown that emodin has a variety of pharmacological activities including anti-tumor, anti-inflammatory and immunoregulatory, antibacterial and anti-viral effects, myocardial protection, neuroprotection, renal protection, bone protection, antifibrosis and so on, which indicate its high medicinal value and broad application prospects.This article aims to summarize the progress in the pharmacological activity and mechanism of action of emodin published in domestic and international journals over the last 5 years and highlight the potential targets and molecular signaling pathways linked with emodin, so as to provide some clues and references for further development and clinical application of emodin.
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