The aim of this study was to investigate factors contributing to left ventricular dysfunction (LVD) in patients who had survived acute myocardial infarction(AMI). Retrospective regression analysis was performed for all the hospitalized patients with AMI who underwent coronary angiography from 1988 to 1998. 155 patients met the entry criteria. Seven patients(4 5%) died of cardiac events after discharge during the ten years′ follow up. In the multivariate logistic regression analysis and stepwise selection, the following factors appeared to be the significantly independent predictors of the LVD after AMI : age, hypertension, hyperlipidemia, LVEF during the first admission, size of infarction, the number of vessel disease, thrombolytic therapy, PTCA. In the COX regression and stepwise selection, the following factors appeared to be significantly independent predictors of the LVD after AMI : hyperlipidemia, LVED during the first admission, size of infarction, the number of vessel disease, thrombolytic therapy , PTCA. The probability of LVD increased with time. Patients with advanced age, hypertension, hyperlipidemia, large infarction, multivessel disease, reduced LVEF after AMI, no thrombolysis and PTCA are prone to develop LVD.

Objective To reveal the effect of lutein on the status of oxidative stress in rats with high homocysteine levels (HHcy) and relevent molecular mechanisms.Methods The wistar rat HHcy model was established by intra-gastric administration with L-methionine suspension and treated with lutein.The oxidative stress status and the gene expression changes of transcription Nf-E2-related factor2 (Nrf2),a regulation factor of down stream antioxidant protein gene expression,were detected in HHcy rats and lutein intervention rats.Results Compared with the rat serum SOD activities (134.32 ± 12.65) U/mL in the control group,the serum SOD activities in the HHcy model group (95.6 ± 10.92) U/mL were significantly lower (P ＜ 0.05).The serum glutathione peroxidase (GPx) activities in the HHcy model group (121.66 ± 18.64) U/mL were also significantly lower as compared with the the control group (183.17 ± 21.29) U/mL,P ＜ 0.05.However,the serum SOD (126.75 ± 11.26) U/mL and GPx activities (167.18 ± 19.66) U/mL in the lutein intervention group were significantly higher as compared with the HHcy model group.As compared with the rat serum malondialdehyde (MDA) content (5.11 ± 0.68) μmol/L as well as the hydroxyl free radical levels (0.53 ± 0.05) U/L in the control group,the serum MDA content (7.65 ± 0.87) μmol/L and the hydroxyl free radical levels (0.92 ± 0.09) U/L in the HHcy model group were significantly higher.The serum MDA content (6.44 ±0.91) μmol/L and the hydroxyl free radical levels (0.74 ± 0.06) U/L in the lutein intervention group were significantly lower as compared with the HHcy model group.RT-PCR and Western blot results also showed decreased expression of SOD2 and GPxl mRNA in aorta epithelial tissues of HHcy model rats.With lutein intervention,the expressions ofSOD2 and GPx1mRNA were significantly increased and the gene expression of Nrf2 also up-regulated.Conclusions The Hhcy model rats were under the status of augmented oxidative stress,and carotenoid lutein could attenuate the Hcy-mediated oxidative stress,and its mechanism might be potentially associated with up-regulating the expression of Nrf2,thereby inducing the expression of its downstream antioxidant proteins.

Objective To explore the influence of seasonal variations on acute cerebral infarction outcome. Meth-ods We collected data from acute cerebral infarction patients in the Second Hospital of Tianjin Medical University from January 2009 to February 2012. All cases were classified by months and seasons into different groups to analyze the season-al variations retrospectively. Results (1) The percentage of good outcome of acute cerebral infarction show significant dif-ference between each month(P<0.01). The percentage of good outcome was highest in August(92.1%), lowest in Decem-ber(78.1%), second lowest in April(81.9%). The percentage of good outcome in summer(91.6%)was higher than spring (87.2%), autumn(86.4%)and winter(83.9%)(P<0.05). (2) Among those patients converted to bad outcome more pa-tients was attacked by cerebrovascular accident in winter(68.3%)than in summer(43.2%), and more patients was combined with a pulmonary infection in winter(69.5%)than in summer(48.6%)and in autumn(49.3%)(P<0.05). (3) Seasonal effect in acute cerebral infarction outcome was obvious in those≥65 years of age(P<0.05). Conclusion Seasonal changes are associated with the outcome and severity of acute cerebral infarction.

Objective To investigate the impact of hyponatremia on the short-term prognosis in patients with acute ST-elevation myocardial infarction (STEMI) treated with percutaneous coronary intervention (PCI).Methods The present study included 324 patients with acute STEMI treated with PCI within 12 hours after admission from March 2014 to May 2016.Patients were divided into three groups according to plasma sodium levels (Na+) at admission:group A with Na+ ＜ 130 mmoL/L,group B with Na + 130-134 mmol/L and group C with Na + ≥ 135 mmol/L (normal plasma sodium level).Clinical data and biochemical variables were compared among the three groups.Logistic regression analysis was used to examine the correlation between plasma sodium levels and short-term prognosis.Results There were significant differences in age,fasting glucose,NT-proBNP,LVEF (left ventricular ejection fraction) and hsCRP (high sensitive C-reactive protein) among the three groups (P ＜ 0.05).The mortality in group A was obviously higher than that in Group B (20.0％ vs.6.3％,P ＜ 0.05) and in group C (20.0％ vs.6.0％,P ＜ 0.05).In addition,there were significant differences in rates of cardiogenic shock and acute renal failure among three groups.Logistic regression analysis showed that old age,low LVEF and hyponatremia were independent risk factors for 30-day mortality (P ＜ 0.05).Compared with group B,patients in group A had significantly high risks of death (OR =3.058,95％ CI:1.339-4.358,P =0.003),suggesting that the high risk of 30-day mortality associated with the severity of hyponatremia.Conclusions At admission,the hyponatremia in patients with acute STEMI treated with PCI is an independent risk factor for 30-day mortality,and prognosis worsens with the severity of hyponatremia.

Wnt/β-catenin signaling pathway is an evolutionarily conserved signaling pathway that plays an important role in embryonic and organ development,which is not only invovled in regulating several cellular proliferation,differentiation,polarity,migration and apoptosis,but aslo playing an critical role in initiation,invasion,metastasis,progression and drug resistance of gastric cancer.This article will review the newest studies about gastric cancer of Wnt/β-catenin and provide fundamenal theories to design new drugs for the treatment of gastric cancer.

Scar is an inevitable consequence of full-thickness skin injury. Hypertrophic scar and keloid are caused by abnormal wound healing. Mechanical factors play an important role in scar formation. An extensive literature review on mechanobiology of scar and wound healing, as well as a summary of the mechanobiological factors of scar formation and treatments, and mechanical model of scar were conducted, with guiding future development in this research field.

Scar is an inevitable consequence of full-thickness skin injury. Hypertrophic scar and keloid are caused by abnormal wound healing. Mechanical factors play an important role in scar formation. An extensive literature review on mechanobiology of scar and wound healing, as well as a summary of the mechanobiological factors of scar formation and treatments, and mechanical model of scar were conducted, with guiding future development in this research field.