Objective The value of using partial spleen embolization (PSE) in the treatment of hyper-splenism. Methods Using mixed antibiotic 60% meglucamine diatrizoate, we injected tiny gelatinsponges as embolus to 34 cases of hypersplenism for making spleen artery embolization between 1989 and 2001. Results In the 34 cases of hypersplenism who used PSE, the 26 cases had gained CR(76.5%)and the 6 cases had gained PR(17.6%). The overall effective rate was 94.1%. Tracing the 26 cases who had gained CR, there were 7 cases relapsed. And the recurrence rate was 26.9%. Conclusion The using areas of PSE are wide. And the curative effect is exact. PSE can completely replace the operation of splenectomy with mastering skill and attending complication.